Preparation and assessment of a new radiotracer technetium-99m-6-hydrazinonicotinic acid-tyrosine as a targeting agent in tumor detecting through single photon emission tomography

The novel radiotracer HYNIC-Tyrosine was synthesized and labeled with 99mTc. This radiotracer was stable as determined by chromatography. Uptake in C6 rat glioma tumor was determined and in whole body scintigraphy, C6 glioma tumor was clearly visible at 1 h post injection. [Display omitted] •A new r...

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Veröffentlicht in:	Bioorganic chemistry 2020-11, Vol.104, p.104181-104181, Article 104181
Hauptverfasser:	Mogadam, Hemat Yaghoubi, Erfani, Mostafa, Nikpassand, Mohammad, Mokhtary, Masoud
Format:	Artikel
Sprache:	eng
Schlagworte:	99mTc Amino acid transporter Animals Glioma - diagnostic imaging HYNIC Molecular Structure Radiopharmaceuticals - chemical synthesis Radiopharmaceuticals - chemistry Rats Tomography, Emission-Computed, Single-Photon Tumor Tumor Cells, Cultured Tyrosine
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