Mitochondrial TXN2 attenuates amyloidogenesis via selective inhibition of BACE1 expression

Thioredoxin‐2 (TXN2) is a mitochondrial protein and represents one of the intrinsic antioxidant enzymes. It has long been recognized that mitochondrial dysfunction and oxidative stress contribute to the pathogenesis of Alzheimer's disease (AD). We hypothesized that mitochondrial TXN2 might play...

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Veröffentlicht in:	Journal of neurochemistry 2021-05, Vol.157 (4), p.1351-1365
Hauptverfasser:	Li, Kun‐Yi, Xiang, Xiao‐Jiao, Song, Li, Chen, Jian, Luo, Biao, Wen, Qi‐Xin, Zhong, Bi‐Rou, Zhou, Gui‐Feng, Deng, Xiao‐Juan, Ma, Yuan‐Lin, Hu, Li‐Tian, Chen, Guo‐Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amyloid precursor protein Amyloidogenesis Animal models Antioxidants Apoptosis BACE1 Cell viability Enzymes Hippocampus Kinases Mitochondria Neurodegenerative diseases NF-κB protein NFκB signaling Oxidative stress Pathogenesis Phosphorylation Precursors Proteins Reactive oxygen species Signaling Thioredoxin Transcription TXN2 β-Site APP-cleaving enzyme 1
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