Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia
Purpose To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness. Methods Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiogra...
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| Veröffentlicht in: | International ophthalmology 2021-02, Vol.41 (2), p.399-407 |
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| creator | Kocer, Ali Mert Kiziltoprak, Hasan Fen, Turgay Goker, Yasin Sakir Acar, Atakan |
| description | Purpose
To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness.
Methods
Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiography was used to determine RNFL thickness and RPCvd measurements. In addition, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ferritin laboratory values were evaluated.
Results
Analysis of retinal regions (whole images, peripapillary, superior-hemi, inferior-hemi, inferior-nasal, inferior-temporal, temporal-inferior, temporal-superior, superior-nasal) showed that RPCvd values were significantly lower in patients with IDA compared to the control group values (
p
0.05 for all). In addition, there were significant positive correlations between RPCvd values and hematological values for Hb, HCT, MCV, MCH, MCHC, and ferritin.
Conclusion
It is important to identify changes in retinal vascularity to prevent possible ocular problems in patients with IDA. Specifically, the significant positive correlations between RPCvd values and hematological values suggest that anemia treatment is important for optic nerve perfusion. |
| doi_str_mv | 10.1007/s10792-020-01589-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2442596921</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2442596921</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-44029eae7b168d6cafbec092e3be18dd12971a65ca269be2f1046d5716a8d2ee3</originalsourceid><addsrcrecordid>eNp9kUFP3DAQha2qVVlo_wCHylIvXEJnnMSOjxWCgoTEpT1bjj0Bo6yT2klX--9xu5RKPXAaS_O9N-N5jJ0inCOA-pIRlBYVCKgA205Xuzdsg62qKyFreMs2gLKtWgV4xI5zfgQArbR8z45qoUUDSm3YePnLjqtdwhT5NPBkfbAjnymF2c5hHG3ac_fy8hRzWPY8RD4XDcUl811YHnik3Vjawd7HKZPnIRU_T0NwBXJ7biNtg_3A3g12zPTxuZ6wH1eX3y-uq9u7bzcXX28rV6t2qZoGhCZLqkfZeens0JMDLajuCTvvUWiFVrbOCql7EgNCI32rUNrOC6L6hJ0dfOc0_VwpL2YbsqPyh0jTmo1oGtFqqQUW9PN_6OO0pli2K1SnEWUjukKJA-XSlHOiwcwpbMtFDIL5nYU5ZGFKFuZPFmZXRJ-erdd-S_5F8vf4BagPQC6teE_p3-xXbJ8ATp2W9g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2489116428</pqid></control><display><type>article</type><title>Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia</title><source>SpringerLink Journals - AutoHoldings</source><creator>Kocer, Ali Mert ; Kiziltoprak, Hasan ; Fen, Turgay ; Goker, Yasin Sakir ; Acar, Atakan</creator><creatorcontrib>Kocer, Ali Mert ; Kiziltoprak, Hasan ; Fen, Turgay ; Goker, Yasin Sakir ; Acar, Atakan</creatorcontrib><description>Purpose
To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness.
Methods
Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiography was used to determine RNFL thickness and RPCvd measurements. In addition, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ferritin laboratory values were evaluated.
Results
Analysis of retinal regions (whole images, peripapillary, superior-hemi, inferior-hemi, inferior-nasal, inferior-temporal, temporal-inferior, temporal-superior, superior-nasal) showed that RPCvd values were significantly lower in patients with IDA compared to the control group values (
p
< 0.05 for all). However, there were no significant differences in RNFL thickness values between the IDA patient group and the control group (
p
> 0.05 for all). In addition, there were significant positive correlations between RPCvd values and hematological values for Hb, HCT, MCV, MCH, MCHC, and ferritin.
Conclusion
It is important to identify changes in retinal vascularity to prevent possible ocular problems in patients with IDA. Specifically, the significant positive correlations between RPCvd values and hematological values suggest that anemia treatment is important for optic nerve perfusion.</description><identifier>ISSN: 0165-5701</identifier><identifier>EISSN: 1573-2630</identifier><identifier>DOI: 10.1007/s10792-020-01589-w</identifier><identifier>PMID: 32924077</identifier><language>eng</language><publisher>Dordrecht: Springer Netherlands</publisher><subject>Anemia ; Angiography ; Blood vessels ; Density ; Evaluation ; Ferritin ; Hematocrit ; Hematology ; Hemoglobin ; Iron ; Iron deficiency ; Medicine ; Medicine & Public Health ; Nutrient deficiency ; Ophthalmology ; Optic nerve ; Original Paper ; Perfusion ; Retina ; Thickness measurement</subject><ispartof>International ophthalmology, 2021-02, Vol.41 (2), p.399-407</ispartof><rights>Springer Nature B.V. 2020</rights><rights>Springer Nature B.V. 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-44029eae7b168d6cafbec092e3be18dd12971a65ca269be2f1046d5716a8d2ee3</citedby><cites>FETCH-LOGICAL-c375t-44029eae7b168d6cafbec092e3be18dd12971a65ca269be2f1046d5716a8d2ee3</cites><orcidid>0000-0001-6847-1560</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10792-020-01589-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10792-020-01589-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32924077$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kocer, Ali Mert</creatorcontrib><creatorcontrib>Kiziltoprak, Hasan</creatorcontrib><creatorcontrib>Fen, Turgay</creatorcontrib><creatorcontrib>Goker, Yasin Sakir</creatorcontrib><creatorcontrib>Acar, Atakan</creatorcontrib><title>Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia</title><title>International ophthalmology</title><addtitle>Int Ophthalmol</addtitle><addtitle>Int Ophthalmol</addtitle><description>Purpose
To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness.
Methods
Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiography was used to determine RNFL thickness and RPCvd measurements. In addition, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ferritin laboratory values were evaluated.
Results
Analysis of retinal regions (whole images, peripapillary, superior-hemi, inferior-hemi, inferior-nasal, inferior-temporal, temporal-inferior, temporal-superior, superior-nasal) showed that RPCvd values were significantly lower in patients with IDA compared to the control group values (
p
< 0.05 for all). However, there were no significant differences in RNFL thickness values between the IDA patient group and the control group (
p
> 0.05 for all). In addition, there were significant positive correlations between RPCvd values and hematological values for Hb, HCT, MCV, MCH, MCHC, and ferritin.
Conclusion
It is important to identify changes in retinal vascularity to prevent possible ocular problems in patients with IDA. Specifically, the significant positive correlations between RPCvd values and hematological values suggest that anemia treatment is important for optic nerve perfusion.</description><subject>Anemia</subject><subject>Angiography</subject><subject>Blood vessels</subject><subject>Density</subject><subject>Evaluation</subject><subject>Ferritin</subject><subject>Hematocrit</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Iron</subject><subject>Iron deficiency</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nutrient deficiency</subject><subject>Ophthalmology</subject><subject>Optic nerve</subject><subject>Original Paper</subject><subject>Perfusion</subject><subject>Retina</subject><subject>Thickness measurement</subject><issn>0165-5701</issn><issn>1573-2630</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kUFP3DAQha2qVVlo_wCHylIvXEJnnMSOjxWCgoTEpT1bjj0Bo6yT2klX--9xu5RKPXAaS_O9N-N5jJ0inCOA-pIRlBYVCKgA205Xuzdsg62qKyFreMs2gLKtWgV4xI5zfgQArbR8z45qoUUDSm3YePnLjqtdwhT5NPBkfbAjnymF2c5hHG3ac_fy8hRzWPY8RD4XDcUl811YHnik3Vjawd7HKZPnIRU_T0NwBXJ7biNtg_3A3g12zPTxuZ6wH1eX3y-uq9u7bzcXX28rV6t2qZoGhCZLqkfZeens0JMDLajuCTvvUWiFVrbOCql7EgNCI32rUNrOC6L6hJ0dfOc0_VwpL2YbsqPyh0jTmo1oGtFqqQUW9PN_6OO0pli2K1SnEWUjukKJA-XSlHOiwcwpbMtFDIL5nYU5ZGFKFuZPFmZXRJ-erdd-S_5F8vf4BagPQC6teE_p3-xXbJ8ATp2W9g</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Kocer, Ali Mert</creator><creator>Kiziltoprak, Hasan</creator><creator>Fen, Turgay</creator><creator>Goker, Yasin Sakir</creator><creator>Acar, Atakan</creator><general>Springer Netherlands</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6847-1560</orcidid></search><sort><creationdate>20210201</creationdate><title>Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia</title><author>Kocer, Ali Mert ; Kiziltoprak, Hasan ; Fen, Turgay ; Goker, Yasin Sakir ; Acar, Atakan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-44029eae7b168d6cafbec092e3be18dd12971a65ca269be2f1046d5716a8d2ee3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Anemia</topic><topic>Angiography</topic><topic>Blood vessels</topic><topic>Density</topic><topic>Evaluation</topic><topic>Ferritin</topic><topic>Hematocrit</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Iron</topic><topic>Iron deficiency</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nutrient deficiency</topic><topic>Ophthalmology</topic><topic>Optic nerve</topic><topic>Original Paper</topic><topic>Perfusion</topic><topic>Retina</topic><topic>Thickness measurement</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kocer, Ali Mert</creatorcontrib><creatorcontrib>Kiziltoprak, Hasan</creatorcontrib><creatorcontrib>Fen, Turgay</creatorcontrib><creatorcontrib>Goker, Yasin Sakir</creatorcontrib><creatorcontrib>Acar, Atakan</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>International ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kocer, Ali Mert</au><au>Kiziltoprak, Hasan</au><au>Fen, Turgay</au><au>Goker, Yasin Sakir</au><au>Acar, Atakan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia</atitle><jtitle>International ophthalmology</jtitle><stitle>Int Ophthalmol</stitle><addtitle>Int Ophthalmol</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>41</volume><issue>2</issue><spage>399</spage><epage>407</epage><pages>399-407</pages><issn>0165-5701</issn><eissn>1573-2630</eissn><abstract>Purpose
To investigate the effects of iron deficiency anemia (IDA) on radial peripapillary capillary vessel density (RPCvd) and retinal nerve fiber layer (RNFL) thickness.
Methods
Forty patients with IDA, and 46 healthy participants, were enrolled in this study. Optical coherence tomography angiography was used to determine RNFL thickness and RPCvd measurements. In addition, hemoglobin (Hb), hematocrit (HCT), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and ferritin laboratory values were evaluated.
Results
Analysis of retinal regions (whole images, peripapillary, superior-hemi, inferior-hemi, inferior-nasal, inferior-temporal, temporal-inferior, temporal-superior, superior-nasal) showed that RPCvd values were significantly lower in patients with IDA compared to the control group values (
p
< 0.05 for all). However, there were no significant differences in RNFL thickness values between the IDA patient group and the control group (
p
> 0.05 for all). In addition, there were significant positive correlations between RPCvd values and hematological values for Hb, HCT, MCV, MCH, MCHC, and ferritin.
Conclusion
It is important to identify changes in retinal vascularity to prevent possible ocular problems in patients with IDA. Specifically, the significant positive correlations between RPCvd values and hematological values suggest that anemia treatment is important for optic nerve perfusion.</abstract><cop>Dordrecht</cop><pub>Springer Netherlands</pub><pmid>32924077</pmid><doi>10.1007/s10792-020-01589-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-6847-1560</orcidid></addata></record> |
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| ispartof | International ophthalmology, 2021-02, Vol.41 (2), p.399-407 |
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| language | eng |
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| subjects | Anemia Angiography Blood vessels Density Evaluation Ferritin Hematocrit Hematology Hemoglobin Iron Iron deficiency Medicine Medicine & Public Health Nutrient deficiency Ophthalmology Optic nerve Original Paper Perfusion Retina Thickness measurement |
| title | Evaluation of radial peripapillary capillary density in patients with newly diagnosed iron deficiency anemia |
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