Protein succination as a potential surrogate biomarker of airway obstruction. The ilervas project
Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress. These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress. The latter can alter metabolite intermediates in the Krebs cycle leading to the format...
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| Veröffentlicht in: | Respiratory medicine 2020-10, Vol.172, p.106124-106124, Article 106124 |
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| creator | González, J. Gracia-Lavedan, E. Pamplona, R. Fernández, E. Lecube, A. de-Torres, J.P. Barbé, F. Torres, G. Benabdelhak, Ikram Bermúdez, Marcelino Castro, Eva de Batlle, Jordi Colàs-Campàs, Laura Hernández, Marta Jové, Mariano Miquel, Eva Martínez, Montserrat |
| description | Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress. These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress. The latter can alter metabolite intermediates in the Krebs cycle leading to the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination). Protein succination has not been described in airways diseases.
To assess differences in levels of AGEs and 2SC between patients with AO and normal spirometry.
and Methods: In this case-control study, we investigated 35 moderate to severe AO patients and 31 subjects with normal spirometry, matched for age, gender, body mass index (BMI), tobacco history, prediabetes and adherence to Mediterranean diet. Plasma 2SC and AGEs concentrations were measured by GS/MS, and AGEs in skin were determined measuring autofluorescence (SAF). Multivariate logistic regression models explored the association between AGEs in the skin, 2SC and the presence of AO.
The population was predominantly middle-age (mean of 58.7 years-old), overweight (median of BMI 26.7 kg/m2) and male subjects (69.7%). Patients with AO showed higher values of SAF (p = 0.04) and 2SC (p = 0.047). No differences were observed for plasma AGEs. SAF and 2SC were significantly associated with the presence of AO after adjusting for age, gender, smoking history, BMI and Mediterranean diet score (p = 0.041 and p = 0.038, respectively).
Skin AGEs and 2SC are increased in patients with moderate to severe AO and independently associated with its presence. Further studies should confirm these findings and explore their potential role as a biomarker for the disease.
•Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress.•These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress.•This leads the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination).•S-(2-succino) cysteine (2SC) levels and AGE skin levels are increased in moderate to severe AO patients.•These molecules have a potential role as biomarkers for AO. |
| doi_str_mv | 10.1016/j.rmed.2020.106124 |
| format | Article |
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To assess differences in levels of AGEs and 2SC between patients with AO and normal spirometry.
and Methods: In this case-control study, we investigated 35 moderate to severe AO patients and 31 subjects with normal spirometry, matched for age, gender, body mass index (BMI), tobacco history, prediabetes and adherence to Mediterranean diet. Plasma 2SC and AGEs concentrations were measured by GS/MS, and AGEs in skin were determined measuring autofluorescence (SAF). Multivariate logistic regression models explored the association between AGEs in the skin, 2SC and the presence of AO.
The population was predominantly middle-age (mean of 58.7 years-old), overweight (median of BMI 26.7 kg/m2) and male subjects (69.7%). Patients with AO showed higher values of SAF (p = 0.04) and 2SC (p = 0.047). No differences were observed for plasma AGEs. SAF and 2SC were significantly associated with the presence of AO after adjusting for age, gender, smoking history, BMI and Mediterranean diet score (p = 0.041 and p = 0.038, respectively).
Skin AGEs and 2SC are increased in patients with moderate to severe AO and independently associated with its presence. Further studies should confirm these findings and explore their potential role as a biomarker for the disease.
•Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress.•These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress.•This leads the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination).•S-(2-succino) cysteine (2SC) levels and AGE skin levels are increased in moderate to severe AO patients.•These molecules have a potential role as biomarkers for AO.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2020.106124</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Advanced glycation end-products ; Advanced glycosylation end products ; Age ; Airway management ; Apoptosis ; Biobanks ; Biomarkers ; Body mass ; Body mass index ; Body size ; Body weight ; Cardiovascular disease ; Cholesterol ; Chronic illnesses ; Chronic obstructive pulmonary disease ; Chronology ; Creatinine ; Cysteine ; Diabetes ; Diet ; Emphysema ; Glycosylation ; Hemoglobin ; Hypoxemia ; Intermediates ; Kidney diseases ; Krebs cycle ; Lung diseases ; Metabolites ; Mitochondria ; Mitochondrial metabolic stress ; Overweight ; Oxidative stress ; Proteins ; Questionnaires ; Regression analysis ; Respiratory tract ; S-(2-succino) cysteine ; Skin ; Skin autofluorescence ; Spirometry ; Systemic inflammation ; Tobacco ; Tricarboxylic acid cycle</subject><ispartof>Respiratory medicine, 2020-10, Vol.172, p.106124-106124, Article 106124</ispartof><rights>2020 Elsevier Ltd</rights><rights>2020. Elsevier Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-76868a971a178c6c90b251626cb524113d2cd3af15e40f94ffc7be5fd89a744e3</citedby><cites>FETCH-LOGICAL-c471t-76868a971a178c6c90b251626cb524113d2cd3af15e40f94ffc7be5fd89a744e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rmed.2020.106124$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids></links><search><creatorcontrib>González, J.</creatorcontrib><creatorcontrib>Gracia-Lavedan, E.</creatorcontrib><creatorcontrib>Pamplona, R.</creatorcontrib><creatorcontrib>Fernández, E.</creatorcontrib><creatorcontrib>Lecube, A.</creatorcontrib><creatorcontrib>de-Torres, J.P.</creatorcontrib><creatorcontrib>Barbé, F.</creatorcontrib><creatorcontrib>Torres, G.</creatorcontrib><creatorcontrib>Benabdelhak, Ikram</creatorcontrib><creatorcontrib>Bermúdez, Marcelino</creatorcontrib><creatorcontrib>Castro, Eva</creatorcontrib><creatorcontrib>de Batlle, Jordi</creatorcontrib><creatorcontrib>Colàs-Campàs, Laura</creatorcontrib><creatorcontrib>Hernández, Marta</creatorcontrib><creatorcontrib>Jové, Mariano</creatorcontrib><creatorcontrib>Miquel, Eva</creatorcontrib><creatorcontrib>Martínez, Montserrat</creatorcontrib><creatorcontrib>the ILERVAS Study Group</creatorcontrib><title>Protein succination as a potential surrogate biomarker of airway obstruction. The ilervas project</title><title>Respiratory medicine</title><description>Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress. These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress. The latter can alter metabolite intermediates in the Krebs cycle leading to the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination). Protein succination has not been described in airways diseases.
To assess differences in levels of AGEs and 2SC between patients with AO and normal spirometry.
and Methods: In this case-control study, we investigated 35 moderate to severe AO patients and 31 subjects with normal spirometry, matched for age, gender, body mass index (BMI), tobacco history, prediabetes and adherence to Mediterranean diet. Plasma 2SC and AGEs concentrations were measured by GS/MS, and AGEs in skin were determined measuring autofluorescence (SAF). Multivariate logistic regression models explored the association between AGEs in the skin, 2SC and the presence of AO.
The population was predominantly middle-age (mean of 58.7 years-old), overweight (median of BMI 26.7 kg/m2) and male subjects (69.7%). Patients with AO showed higher values of SAF (p = 0.04) and 2SC (p = 0.047). No differences were observed for plasma AGEs. SAF and 2SC were significantly associated with the presence of AO after adjusting for age, gender, smoking history, BMI and Mediterranean diet score (p = 0.041 and p = 0.038, respectively).
Skin AGEs and 2SC are increased in patients with moderate to severe AO and independently associated with its presence. Further studies should confirm these findings and explore their potential role as a biomarker for the disease.
•Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress.•These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress.•This leads the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination).•S-(2-succino) cysteine (2SC) levels and AGE skin levels are increased in moderate to severe AO patients.•These molecules have a potential role as biomarkers for AO.</description><subject>Advanced glycation end-products</subject><subject>Advanced glycosylation end products</subject><subject>Age</subject><subject>Airway management</subject><subject>Apoptosis</subject><subject>Biobanks</subject><subject>Biomarkers</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Body weight</subject><subject>Cardiovascular disease</subject><subject>Cholesterol</subject><subject>Chronic illnesses</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Chronology</subject><subject>Creatinine</subject><subject>Cysteine</subject><subject>Diabetes</subject><subject>Diet</subject><subject>Emphysema</subject><subject>Glycosylation</subject><subject>Hemoglobin</subject><subject>Hypoxemia</subject><subject>Intermediates</subject><subject>Kidney diseases</subject><subject>Krebs cycle</subject><subject>Lung diseases</subject><subject>Metabolites</subject><subject>Mitochondria</subject><subject>Mitochondrial metabolic stress</subject><subject>Overweight</subject><subject>Oxidative stress</subject><subject>Proteins</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Respiratory tract</subject><subject>S-(2-succino) cysteine</subject><subject>Skin</subject><subject>Skin autofluorescence</subject><subject>Spirometry</subject><subject>Systemic inflammation</subject><subject>Tobacco</subject><subject>Tricarboxylic acid cycle</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kD1PwzAQhi0EEqXwB5gssbCk-BzHSSQWVPElVYKhzJbjXMAhjYudFPXf46hMDEwn3T3v2fcQcglsAQzkTbvwG6wXnPGpIYGLIzKDLOVJyqQ4JjNWZiKRAHBKzkJoGWOlEGxG9Kt3A9qehtEY2-vBup7qQDXdxn4_WN3FkffuXQ9IK-s22n-ip66h2vpvvaeuCoMfzRRc0PUHUtuh38UVW-9aNMM5OWl0F_Dit87J28P9evmUrF4en5d3q8SIHIYkl4UsdJmDhrww0pSs4hlILk2VcQGQ1tzUqW4gQ8GaUjSNySvMmroodS4EpnNyfdgb3_0aMQxqY4PBrtM9ujEoLgTnUBYCInr1B23d6Pv4u4kqUsmKPIsUP1DGuxA8NmrrbTx_r4Cpybpq1WRdTdbVwXoM3R5CGE_dWfQqGIu9wdr6KEPVzv4X_wFGHotS</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>González, J.</creator><creator>Gracia-Lavedan, E.</creator><creator>Pamplona, R.</creator><creator>Fernández, E.</creator><creator>Lecube, A.</creator><creator>de-Torres, J.P.</creator><creator>Barbé, F.</creator><creator>Torres, G.</creator><creator>Benabdelhak, Ikram</creator><creator>Bermúdez, Marcelino</creator><creator>Castro, Eva</creator><creator>de Batlle, Jordi</creator><creator>Colàs-Campàs, Laura</creator><creator>Hernández, Marta</creator><creator>Jové, Mariano</creator><creator>Miquel, Eva</creator><creator>Martínez, Montserrat</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>202010</creationdate><title>Protein succination as a potential surrogate biomarker of airway obstruction. The ilervas project</title><author>González, J. ; Gracia-Lavedan, E. ; Pamplona, R. ; Fernández, E. ; Lecube, A. ; de-Torres, J.P. ; Barbé, F. ; Torres, G. ; Benabdelhak, Ikram ; Bermúdez, Marcelino ; Castro, Eva ; de Batlle, Jordi ; Colàs-Campàs, Laura ; Hernández, Marta ; Jové, Mariano ; Miquel, Eva ; Martínez, Montserrat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-76868a971a178c6c90b251626cb524113d2cd3af15e40f94ffc7be5fd89a744e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Advanced glycation end-products</topic><topic>Advanced glycosylation end products</topic><topic>Age</topic><topic>Airway management</topic><topic>Apoptosis</topic><topic>Biobanks</topic><topic>Biomarkers</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Body weight</topic><topic>Cardiovascular disease</topic><topic>Cholesterol</topic><topic>Chronic illnesses</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Chronology</topic><topic>Creatinine</topic><topic>Cysteine</topic><topic>Diabetes</topic><topic>Diet</topic><topic>Emphysema</topic><topic>Glycosylation</topic><topic>Hemoglobin</topic><topic>Hypoxemia</topic><topic>Intermediates</topic><topic>Kidney diseases</topic><topic>Krebs cycle</topic><topic>Lung diseases</topic><topic>Metabolites</topic><topic>Mitochondria</topic><topic>Mitochondrial metabolic stress</topic><topic>Overweight</topic><topic>Oxidative stress</topic><topic>Proteins</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Respiratory tract</topic><topic>S-(2-succino) cysteine</topic><topic>Skin</topic><topic>Skin autofluorescence</topic><topic>Spirometry</topic><topic>Systemic inflammation</topic><topic>Tobacco</topic><topic>Tricarboxylic acid cycle</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González, J.</creatorcontrib><creatorcontrib>Gracia-Lavedan, E.</creatorcontrib><creatorcontrib>Pamplona, R.</creatorcontrib><creatorcontrib>Fernández, E.</creatorcontrib><creatorcontrib>Lecube, A.</creatorcontrib><creatorcontrib>de-Torres, J.P.</creatorcontrib><creatorcontrib>Barbé, F.</creatorcontrib><creatorcontrib>Torres, G.</creatorcontrib><creatorcontrib>Benabdelhak, Ikram</creatorcontrib><creatorcontrib>Bermúdez, Marcelino</creatorcontrib><creatorcontrib>Castro, Eva</creatorcontrib><creatorcontrib>de Batlle, Jordi</creatorcontrib><creatorcontrib>Colàs-Campàs, Laura</creatorcontrib><creatorcontrib>Hernández, Marta</creatorcontrib><creatorcontrib>Jové, Mariano</creatorcontrib><creatorcontrib>Miquel, Eva</creatorcontrib><creatorcontrib>Martínez, Montserrat</creatorcontrib><creatorcontrib>the ILERVAS Study Group</creatorcontrib><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González, J.</au><au>Gracia-Lavedan, E.</au><au>Pamplona, R.</au><au>Fernández, E.</au><au>Lecube, A.</au><au>de-Torres, J.P.</au><au>Barbé, F.</au><au>Torres, G.</au><au>Benabdelhak, Ikram</au><au>Bermúdez, Marcelino</au><au>Castro, Eva</au><au>de Batlle, Jordi</au><au>Colàs-Campàs, Laura</au><au>Hernández, Marta</au><au>Jové, Mariano</au><au>Miquel, Eva</au><au>Martínez, Montserrat</au><aucorp>the ILERVAS Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protein succination as a potential surrogate biomarker of airway obstruction. The ilervas project</atitle><jtitle>Respiratory medicine</jtitle><date>2020-10</date><risdate>2020</risdate><volume>172</volume><spage>106124</spage><epage>106124</epage><pages>106124-106124</pages><artnum>106124</artnum><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress. These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress. The latter can alter metabolite intermediates in the Krebs cycle leading to the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination). Protein succination has not been described in airways diseases.
To assess differences in levels of AGEs and 2SC between patients with AO and normal spirometry.
and Methods: In this case-control study, we investigated 35 moderate to severe AO patients and 31 subjects with normal spirometry, matched for age, gender, body mass index (BMI), tobacco history, prediabetes and adherence to Mediterranean diet. Plasma 2SC and AGEs concentrations were measured by GS/MS, and AGEs in skin were determined measuring autofluorescence (SAF). Multivariate logistic regression models explored the association between AGEs in the skin, 2SC and the presence of AO.
The population was predominantly middle-age (mean of 58.7 years-old), overweight (median of BMI 26.7 kg/m2) and male subjects (69.7%). Patients with AO showed higher values of SAF (p = 0.04) and 2SC (p = 0.047). No differences were observed for plasma AGEs. SAF and 2SC were significantly associated with the presence of AO after adjusting for age, gender, smoking history, BMI and Mediterranean diet score (p = 0.041 and p = 0.038, respectively).
Skin AGEs and 2SC are increased in patients with moderate to severe AO and independently associated with its presence. Further studies should confirm these findings and explore their potential role as a biomarker for the disease.
•Airway obstruction (AO) is associated with hypoxemia, systemic inflammation and oxidative stress.•These conditions can favor the formation of Advanced Glycation End-products (AGEs) and induce mitochondrial stress.•This leads the formation of the cysteine-fumarate adduct S-(2-succino) cysteine (2SC) in proteins (protein succination).•S-(2-succino) cysteine (2SC) levels and AGE skin levels are increased in moderate to severe AO patients.•These molecules have a potential role as biomarkers for AO.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.rmed.2020.106124</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Advanced glycation end-products Advanced glycosylation end products Age Airway management Apoptosis Biobanks Biomarkers Body mass Body mass index Body size Body weight Cardiovascular disease Cholesterol Chronic illnesses Chronic obstructive pulmonary disease Chronology Creatinine Cysteine Diabetes Diet Emphysema Glycosylation Hemoglobin Hypoxemia Intermediates Kidney diseases Krebs cycle Lung diseases Metabolites Mitochondria Mitochondrial metabolic stress Overweight Oxidative stress Proteins Questionnaires Regression analysis Respiratory tract S-(2-succino) cysteine Skin Skin autofluorescence Spirometry Systemic inflammation Tobacco Tricarboxylic acid cycle |
| title | Protein succination as a potential surrogate biomarker of airway obstruction. The ilervas project |
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