Analysis of the acrolein-modified sites of apolipoprotein B-100 in LDL

We have reported that acrolein-conjugated low-density lipoprotein (Acro-LDL) uptake by scavenger receptor class A type 1 (SR-A1) can mediate macrophage foam cell formation. The purpose of this study was to determine which amino acid residues of apoB protein in LDL are conjugated with acrolein. Acro-...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2021-01, Vol.1866 (1), p.158809-158809, Article 158809
Hauptverfasser:	Kobayashi, Mizuki, Watanabe, Kenta, Suzuki, Takehiro, Dohmae, Naoshi, Fujiyoshi, Masachika, Uchida, Masashi, Suzuki, Takaaki, Igarashi, Kazuei, Ishii, Itsuko
Format:	Artikel
Sprache:	eng
Schlagworte:	Acrolein Acrolein - chemistry Amino Acid Sequence Apolipoprotein B-100 Apolipoprotein B-100 - chemistry Apolipoprotein B-100 - genetics Apolipoprotein B-100 - metabolism Binding Sites Cholesterol, LDL - chemistry Cholesterol, LDL - metabolism Gene Expression Humans LDL Mass spectrometry Models, Molecular Protein Binding Protein Conformation, alpha-Helical Protein Conformation, beta-Strand Protein Interaction Domains and Motifs Serine-Arginine Splicing Factors - chemistry Serine-Arginine Splicing Factors - genetics Serine-Arginine Splicing Factors - metabolism THP-1 Cells
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