ORP2, a cholesterol transporter, regulates angiogenic signaling in endothelial cells

Oxysterol‐binding protein‐related protein 2 (ORP2), a cholesterol‐PI(4,5)P2 countercurrent transporter, was recently identified as a novel regulator of plasma membrane (PM) cholesterol and PI(4,5)P2 content in HeLa cells. Here, we investigate the role of ORP2 in endothelial cell (EC) cholesterol and...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The FASEB journal 2020-11, Vol.34 (11), p.14671-14694
Hauptverfasser:	Koponen, Annika, Pan, Guoping, Kivelä, Annukka M., Ralko, Arthur, Taskinen, Juuso H., Arora, Amita, Kosonen, Riikka, Kari, Otto K., Ndika, Joseph, Ikonen, Elina, Cho, Wonhwa, Yan, Daoguang, Olkkonen, Vesa M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism angiogenesis Antigens, CD - metabolism Cadherins - metabolism Caveolins - metabolism Cell Membrane - metabolism Cell Movement cholesterol trafficking Endosomes - metabolism Human Umbilical Vein Endothelial Cells - metabolism Human Umbilical Vein Endothelial Cells - physiology Humans Matrix Metalloproteinases - metabolism Neovascularization, Physiologic Nitric Oxide Synthase Type III - metabolism Osbpl2 Phosphatidylinositol 4,5-Diphosphate - metabolism Proto-Oncogene Proteins c-akt - metabolism Receptors, Notch - metabolism Receptors, Steroid - genetics Receptors, Steroid - metabolism Receptors, Vascular Endothelial Growth Factor - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism VEGF receptor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!