Discovery of Novel Pyrazolo[3,4‑b] Pyridine Derivatives with Dual Activities of Vascular Remodeling Inhibition and Vasodilation for the Treatment of Pulmonary Arterial Hypertension

Current pulmonary arterial hypertension (PAH) therapeutic strategies mainly focus on vascular relaxation with less emphasis on vascular remodeling, which results in poor prognosis. Hence, dual pathway regulators with vasodilation effect via soluble guanylate cyclase (sGC) stimulation and vascular re...

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Veröffentlicht in:	Journal of medicinal chemistry 2020-10, Vol.63 (19), p.11215-11234
Hauptverfasser:	Hu, Liqing, Li, Lijun, Chang, Qi, Fu, Songsen, Qin, Jia, Chen, Zhuo, Li, Xiaohui, Liu, Qinglian, Hu, Gaoyun, Li, Qianbin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Kinase - antagonists & inhibitors Adenylate Kinase - metabolism Animals Cell Line Drug Design Humans Hypertension, Pulmonary - drug therapy Pyrazoles - chemistry Pyrazoles - pharmacology Pyridines - chemistry Pyridines - pharmacology Rats Structure-Activity Relationship Vascular Remodeling - drug effects Vasodilation - drug effects
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