Metabolic tumor volume and total lesion glycolysis as prognostic factors in head and neck cancer: Systematic review and meta‐analysis
The role of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in head and neck cancer (HNC) prognosis is not well established. We conducted a systematic review focusing on MTV and TLG measured by 18F‐FDG positron‐emission tomography in HNC. Meta‐analyses were developed, estimating hazar...
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| Veröffentlicht in: | Head & neck 2020-12, Vol.42 (12), p.3744-3754 |
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| creator | Rijo‐Cedeño, Jefferson Mucientes, Jorge Álvarez, Oscar Royuela, Ana Seijas Marcos, Sara Romero, Jesús García‐Berrocal, José Ramón |
| description | The role of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in head and neck cancer (HNC) prognosis is not well established. We conducted a systematic review focusing on MTV and TLG measured by 18F‐FDG positron‐emission tomography in HNC. Meta‐analyses were developed, estimating hazard ratios (HRs) for overall survival (OS) and disease‐free survival (DFS). Eighteen studies were found with a total of 1512 patients. MTV‐adjusted analysis had an HR of 4.65 (95% CI = 2.04‐10.6) for DFS and 3.89 (95% CI = 1.47‐10.30) for OS. TLG‐unadjusted analysis had an HR of 3.19 (95% CI = 2.33‐4.37) for DFS and 2.48 (95% CI = 1.82‐3.39) for OS. TLG‐adjusted analysis for DFS obtained an HR of 2.05 (95% CI = 0.96‐4.39). MTV and TLG are good prognostic factors in HNC, as high values predict a worse OS and DFS. Given the important information they provide, these parameters may be considered in clinical practice, as they are easily obtainable with current technology. |
| doi_str_mv | 10.1002/hed.26461 |
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We conducted a systematic review focusing on MTV and TLG measured by 18F‐FDG positron‐emission tomography in HNC. Meta‐analyses were developed, estimating hazard ratios (HRs) for overall survival (OS) and disease‐free survival (DFS). Eighteen studies were found with a total of 1512 patients. MTV‐adjusted analysis had an HR of 4.65 (95% CI = 2.04‐10.6) for DFS and 3.89 (95% CI = 1.47‐10.30) for OS. TLG‐unadjusted analysis had an HR of 3.19 (95% CI = 2.33‐4.37) for DFS and 2.48 (95% CI = 1.82‐3.39) for OS. TLG‐adjusted analysis for DFS obtained an HR of 2.05 (95% CI = 0.96‐4.39). MTV and TLG are good prognostic factors in HNC, as high values predict a worse OS and DFS. 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We conducted a systematic review focusing on MTV and TLG measured by 18F‐FDG positron‐emission tomography in HNC. Meta‐analyses were developed, estimating hazard ratios (HRs) for overall survival (OS) and disease‐free survival (DFS). Eighteen studies were found with a total of 1512 patients. MTV‐adjusted analysis had an HR of 4.65 (95% CI = 2.04‐10.6) for DFS and 3.89 (95% CI = 1.47‐10.30) for OS. TLG‐unadjusted analysis had an HR of 3.19 (95% CI = 2.33‐4.37) for DFS and 2.48 (95% CI = 1.82‐3.39) for OS. TLG‐adjusted analysis for DFS obtained an HR of 2.05 (95% CI = 0.96‐4.39). MTV and TLG are good prognostic factors in HNC, as high values predict a worse OS and DFS. Given the important information they provide, these parameters may be considered in clinical practice, as they are easily obtainable with current technology.</description><subject>cancer</subject><subject>Glycolysis</subject><subject>Head & neck cancer</subject><subject>head and neck</subject><subject>Medical prognosis</subject><subject>Meta-analysis</subject><subject>Metabolism</subject><subject>MTV</subject><subject>PET</subject><subject>Survival</subject><subject>Systematic review</subject><subject>TLG</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp1kb1O3jAUhi1EBZR26A1UlljaIeC_L8bdKn4rUXVoO0cn9gkEnBjsBJSNrWuvkSvByQdLpUqWbB0957GPX0I-cLbPGRMHV-j2RalKvkF2ODO6YFLpzfmsZCGZVtvkbUrXjDFZKrFFtqUwXCmtdsif7zhAHXxr6TB2IdL74McOKfSODmEATz2mNvT00k82-Cm1iUKitzFc9iENua0BO4SYaNvTKwS3dPZob6iF3mL8Qn9OacAOZjbifYsPC9Lle58e_0IPi_QdedOAT_j-Zd8lv09Pfh2dFxc_zr4dfb0orOKGF7VujGxErbQxCKVUNdcAtXB61TjnFJNw2AgORug6LzX_hhIruao1d44LuUs-rb15grsR01B1bbLoPfQYxlQJpXjJVnpB9_5Br8MY83tnqmTcaH1oMvV5TdkYUorYVLex7SBOFWfVnE6V06mWdDL78cU41l2uvpKvcWTgYA08tB6n_5uq85PjtfIZbICa9g</recordid><startdate>202012</startdate><enddate>202012</enddate><creator>Rijo‐Cedeño, Jefferson</creator><creator>Mucientes, Jorge</creator><creator>Álvarez, Oscar</creator><creator>Royuela, Ana</creator><creator>Seijas Marcos, Sara</creator><creator>Romero, Jesús</creator><creator>García‐Berrocal, José Ramón</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6313-7061</orcidid></search><sort><creationdate>202012</creationdate><title>Metabolic tumor volume and total lesion glycolysis as prognostic factors in head and neck cancer: Systematic review and meta‐analysis</title><author>Rijo‐Cedeño, Jefferson ; Mucientes, Jorge ; Álvarez, Oscar ; Royuela, Ana ; Seijas Marcos, Sara ; Romero, Jesús ; García‐Berrocal, José Ramón</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4191-b7f93f2b4799ea634b17aab2d75fddd403a8f21a927b27b4109742535b71dd123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>cancer</topic><topic>Glycolysis</topic><topic>Head & neck cancer</topic><topic>head and neck</topic><topic>Medical prognosis</topic><topic>Meta-analysis</topic><topic>Metabolism</topic><topic>MTV</topic><topic>PET</topic><topic>Survival</topic><topic>Systematic review</topic><topic>TLG</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rijo‐Cedeño, Jefferson</creatorcontrib><creatorcontrib>Mucientes, Jorge</creatorcontrib><creatorcontrib>Álvarez, Oscar</creatorcontrib><creatorcontrib>Royuela, Ana</creatorcontrib><creatorcontrib>Seijas Marcos, Sara</creatorcontrib><creatorcontrib>Romero, Jesús</creatorcontrib><creatorcontrib>García‐Berrocal, José Ramón</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rijo‐Cedeño, Jefferson</au><au>Mucientes, Jorge</au><au>Álvarez, Oscar</au><au>Royuela, Ana</au><au>Seijas Marcos, Sara</au><au>Romero, Jesús</au><au>García‐Berrocal, José Ramón</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic tumor volume and total lesion glycolysis as prognostic factors in head and neck cancer: Systematic review and meta‐analysis</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2020-12</date><risdate>2020</risdate><volume>42</volume><issue>12</issue><spage>3744</spage><epage>3754</epage><pages>3744-3754</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>The role of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in head and neck cancer (HNC) prognosis is not well established. We conducted a systematic review focusing on MTV and TLG measured by 18F‐FDG positron‐emission tomography in HNC. Meta‐analyses were developed, estimating hazard ratios (HRs) for overall survival (OS) and disease‐free survival (DFS). Eighteen studies were found with a total of 1512 patients. MTV‐adjusted analysis had an HR of 4.65 (95% CI = 2.04‐10.6) for DFS and 3.89 (95% CI = 1.47‐10.30) for OS. TLG‐unadjusted analysis had an HR of 3.19 (95% CI = 2.33‐4.37) for DFS and 2.48 (95% CI = 1.82‐3.39) for OS. TLG‐adjusted analysis for DFS obtained an HR of 2.05 (95% CI = 0.96‐4.39). MTV and TLG are good prognostic factors in HNC, as high values predict a worse OS and DFS. 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| subjects | cancer Glycolysis Head & neck cancer head and neck Medical prognosis Meta-analysis Metabolism MTV PET Survival Systematic review TLG |
| title | Metabolic tumor volume and total lesion glycolysis as prognostic factors in head and neck cancer: Systematic review and meta‐analysis |
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