BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer
Background Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expre...
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| Veröffentlicht in: | Journal of gastrointestinal cancer 2021-09, Vol.52 (3), p.928-931 |
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| container_issue | 3 |
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| container_title | Journal of gastrointestinal cancer |
| container_volume | 52 |
| creator | Behzadi, Shiva Baradaran, Behzad Hosseinpourfeizi, Mohammad Ali Dastmalchi, Narges Rajabi, Ali Asadi, Milad Safaralizadeh, Reza |
| description | Background
Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression.
Objective
The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC.
Methods
QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated.
Results
BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (
P
= 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters.
Conclusion
LncRNA BC032913 may be considered as an impressive therapeutic target for GC. |
| doi_str_mv | 10.1007/s12029-020-00517-6 |
| format | Article |
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Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression.
Objective
The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC.
Methods
QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated.
Results
BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (
P
= 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters.
Conclusion
LncRNA BC032913 may be considered as an impressive therapeutic target for GC.</description><identifier>ISSN: 1941-6628</identifier><identifier>EISSN: 1941-6636</identifier><identifier>DOI: 10.1007/s12029-020-00517-6</identifier><identifier>PMID: 32914372</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>beta-Carotene 15,15'-Monooxygenase - genetics ; Cancer Research ; Down-Regulation ; Gastroenterology ; Humans ; Internal Medicine ; Medicine ; Medicine & Public Health ; Oncology ; Original Research ; Radiotherapy ; RNA, Long Noncoding - genetics ; Stomach Neoplasms - genetics</subject><ispartof>Journal of gastrointestinal cancer, 2021-09, Vol.52 (3), p.928-931</ispartof><rights>Springer Science+Business Media, LLC, part of Springer Nature 2020</rights><rights>2020. Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-89e47ef92ec09203af646ad49e5662d9deed6438f779b3d643e267222d908ffa3</citedby><cites>FETCH-LOGICAL-c347t-89e47ef92ec09203af646ad49e5662d9deed6438f779b3d643e267222d908ffa3</cites><orcidid>0000-0002-6970-6998</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12029-020-00517-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12029-020-00517-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32914372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Behzadi, Shiva</creatorcontrib><creatorcontrib>Baradaran, Behzad</creatorcontrib><creatorcontrib>Hosseinpourfeizi, Mohammad Ali</creatorcontrib><creatorcontrib>Dastmalchi, Narges</creatorcontrib><creatorcontrib>Rajabi, Ali</creatorcontrib><creatorcontrib>Asadi, Milad</creatorcontrib><creatorcontrib>Safaralizadeh, Reza</creatorcontrib><title>BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer</title><title>Journal of gastrointestinal cancer</title><addtitle>J Gastrointest Canc</addtitle><addtitle>J Gastrointest Cancer</addtitle><description>Background
Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression.
Objective
The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC.
Methods
QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated.
Results
BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (
P
= 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters.
Conclusion
LncRNA BC032913 may be considered as an impressive therapeutic target for GC.</description><subject>beta-Carotene 15,15'-Monooxygenase - genetics</subject><subject>Cancer Research</subject><subject>Down-Regulation</subject><subject>Gastroenterology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Oncology</subject><subject>Original Research</subject><subject>Radiotherapy</subject><subject>RNA, Long Noncoding - genetics</subject><subject>Stomach Neoplasms - genetics</subject><issn>1941-6628</issn><issn>1941-6636</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1OwzAQhC0EolB4AQ7IRy4B_8WOjyVAQapaCcHZcpNNlSp1ip2AeHtcUnrktLPa2dHuh9AVJbeUEHUXKCNMJ4SRhJCUqkQeoTOqBU2k5PL4oFk2QuchrAmRIqX0FI0401Rwxc7Q4j4nu45jG7DF8_YTGjxxXR3ABYi9S4q2rN0Kv84nuA74of1yHlZ9Yzsoce3w1IbO1wXOrSvAX6CTyjYBLvd1jN6fHt_y52S2mL7kk1lScKG6JNMgFFSaQUE0I9xWUkhbCg1pvLfUJUApBc8qpfSS7yQwqRiLI5JVleVjdDPkbn370UPozKYOBTSNddD2wTAhqCSpUGm0ssFa-DYED5XZ-npj_behxOxAmgGkiSDNL0gj49L1Pr9fbqA8rPyRiwY-GEIcuRV4s2577-LP_8X-AI2jeyM</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Behzadi, Shiva</creator><creator>Baradaran, Behzad</creator><creator>Hosseinpourfeizi, Mohammad Ali</creator><creator>Dastmalchi, Narges</creator><creator>Rajabi, Ali</creator><creator>Asadi, Milad</creator><creator>Safaralizadeh, Reza</creator><general>Springer US</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6970-6998</orcidid></search><sort><creationdate>20210901</creationdate><title>BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer</title><author>Behzadi, Shiva ; Baradaran, Behzad ; Hosseinpourfeizi, Mohammad Ali ; Dastmalchi, Narges ; Rajabi, Ali ; Asadi, Milad ; Safaralizadeh, Reza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-89e47ef92ec09203af646ad49e5662d9deed6438f779b3d643e267222d908ffa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>beta-Carotene 15,15'-Monooxygenase - genetics</topic><topic>Cancer Research</topic><topic>Down-Regulation</topic><topic>Gastroenterology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Oncology</topic><topic>Original Research</topic><topic>Radiotherapy</topic><topic>RNA, Long Noncoding - genetics</topic><topic>Stomach Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Behzadi, Shiva</creatorcontrib><creatorcontrib>Baradaran, Behzad</creatorcontrib><creatorcontrib>Hosseinpourfeizi, Mohammad Ali</creatorcontrib><creatorcontrib>Dastmalchi, Narges</creatorcontrib><creatorcontrib>Rajabi, Ali</creatorcontrib><creatorcontrib>Asadi, Milad</creatorcontrib><creatorcontrib>Safaralizadeh, Reza</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Behzadi, Shiva</au><au>Baradaran, Behzad</au><au>Hosseinpourfeizi, Mohammad Ali</au><au>Dastmalchi, Narges</au><au>Rajabi, Ali</au><au>Asadi, Milad</au><au>Safaralizadeh, Reza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer</atitle><jtitle>Journal of gastrointestinal cancer</jtitle><stitle>J Gastrointest Canc</stitle><addtitle>J Gastrointest Cancer</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>52</volume><issue>3</issue><spage>928</spage><epage>931</epage><pages>928-931</pages><issn>1941-6628</issn><eissn>1941-6636</eissn><abstract>Background
Long non-coding RNAs (lncRNAs) are a subset of non-coding RNAs. Abnormal expression of lncRNAs is associated with the development of cancers including gastric cancer (GC). Increasing evidence in this field reveals that lncRNAs have a key role in biological actions via modulating the expression of genes at various genomic levels. BC032913, as a novel antisense lncRNA, may have a role in GC progression.
Objective
The very aim of this study was to examine the clinical significance and the functional role of lncRNA BC032913 in GC.
Methods
QRT-PCR technique was exerted to survey the expression level of BC032913 in GC tissues and matched adjacent non-tumorous tissues. Furthermore, the association between clinicopathological parameters and the expression level of BC032913 was evaluated.
Results
BC032913 expression was downregulated in cancerous tissues as compared with adjacent non-tumorous tissues (
P
= 0.0108). Downregulation of BC032913 expression did not demonstrate a significant association with clinicopathological parameters.
Conclusion
LncRNA BC032913 may be considered as an impressive therapeutic target for GC.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>32914372</pmid><doi>10.1007/s12029-020-00517-6</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0002-6970-6998</orcidid></addata></record> |
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| ispartof | Journal of gastrointestinal cancer, 2021-09, Vol.52 (3), p.928-931 |
| issn | 1941-6628 1941-6636 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | beta-Carotene 15,15'-Monooxygenase - genetics Cancer Research Down-Regulation Gastroenterology Humans Internal Medicine Medicine Medicine & Public Health Oncology Original Research Radiotherapy RNA, Long Noncoding - genetics Stomach Neoplasms - genetics |
| title | BC032913 as a Novel Antisense Non-coding RNA is Downregulated in Gastric Cancer |
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