Early recurrence after pulmonary vein isolation is associated with inferior long‐term outcomes: Insights from a retrospective cohort study
Aims The aim of this retrospective cohort study was to assess the influence of early recurrence (ER) after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) on long‐term outcomes and to identify clinical variables associated with ER. Methods We retrospectively collected clinical...
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| Veröffentlicht in: | Pacing and clinical electrophysiology 2020-10, Vol.43 (10), p.1156-1164 |
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| creator | Kalinsek, Tine Prolic Kottmaier, Marc Telishevska, Marta Berger, Florian Semmler, Verena Popa, Miruna Brkic, Amir Lengauer, Sarah Otgonbayar, Ulamnemekh Koch‐Büttner, Katharina Bartowiak, Marcin Kornmayer, Marielouise Brooks, Stephanie Risse, Elena Kathan, Susanne Hofmann, Monika Grebmer, Christian Reents, Tilko Hessling, Gabriele Deisenhofer, Isabel Bourier, Felix |
| description | Aims
The aim of this retrospective cohort study was to assess the influence of early recurrence (ER) after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) on long‐term outcomes and to identify clinical variables associated with ER.
Methods
We retrospectively collected clinical and procedural data from 1285 patients with paroxysmal AF who underwent PVI from 2011 to 2016. Kaplan‐Meier, receiver operating characteristic (ROC) curve, logistic and Cox regression analyses were performed to analyze the influence of ER on long‐term outcomes.
Results
ER was observed in 13% of patients. Kaplan‐Meier analyses showed significantly different outcomes in 1285 patients with and without ER (49% vs 74%, log rank P |
| doi_str_mv | 10.1111/pace.14060 |
| format | Article |
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The aim of this retrospective cohort study was to assess the influence of early recurrence (ER) after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) on long‐term outcomes and to identify clinical variables associated with ER.
Methods
We retrospectively collected clinical and procedural data from 1285 patients with paroxysmal AF who underwent PVI from 2011 to 2016. Kaplan‐Meier, receiver operating characteristic (ROC) curve, logistic and Cox regression analyses were performed to analyze the influence of ER on long‐term outcomes.
Results
ER was observed in 13% of patients. Kaplan‐Meier analyses showed significantly different outcomes in 1285 patients with and without ER (49% vs 74%, log rank P < .01) and in 286 patients in the subgroup that underwent reablation (44% vs 79%, log rank P < .01). The hazard ratio (HR) of ER was 1.7 within 48 hours (5% of patients), 2.7 within 1 month (5%), 3.0 within 2 months (2%), and 6.4 within 3 months (1%) for late recurrence (LR), P < .01. ROC analysis (area under the curve [AUC] = 0.79) resulted in 70.3% sensitivity and 74.2% specificity for a 14‐day blanking period, and 53.1% sensitivity and 85.5% specificity for a 30‐day blanking period. Female patients (odds ratio [OR] 1.69, P < .01) and those with diabetes (OR 1.95, P = .01) were at higher risk for ER.
Conclusions
ER is observed in a substantial number of patients with paroxysmal AF after PVI and has a continuous direct effect on LR according to the timing of ER. Randomized trials are required to assess the safety and effects of reablations in a shortened blanking period on long‐term outcomes.</description><identifier>ISSN: 0147-8389</identifier><identifier>EISSN: 1540-8159</identifier><identifier>DOI: 10.1111/pace.14060</identifier><identifier>PMID: 32895960</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>atrial fibrillation ; blanking period ; Cardiac arrhythmia ; catheter ablation ; Clinical trials ; Cohort analysis ; Diabetes mellitus ; early recurrence ; Fibrillation</subject><ispartof>Pacing and clinical electrophysiology, 2020-10, Vol.43 (10), p.1156-1164</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3570-11ac40be545311bc026c4b236562ae0fc810c6eae3350aa265791922f0305d63</citedby><cites>FETCH-LOGICAL-c3570-11ac40be545311bc026c4b236562ae0fc810c6eae3350aa265791922f0305d63</cites><orcidid>0000-0003-4861-6595 ; 0000-0002-7742-5598</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fpace.14060$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fpace.14060$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32895960$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kalinsek, Tine Prolic</creatorcontrib><creatorcontrib>Kottmaier, Marc</creatorcontrib><creatorcontrib>Telishevska, Marta</creatorcontrib><creatorcontrib>Berger, Florian</creatorcontrib><creatorcontrib>Semmler, Verena</creatorcontrib><creatorcontrib>Popa, Miruna</creatorcontrib><creatorcontrib>Brkic, Amir</creatorcontrib><creatorcontrib>Lengauer, Sarah</creatorcontrib><creatorcontrib>Otgonbayar, Ulamnemekh</creatorcontrib><creatorcontrib>Koch‐Büttner, Katharina</creatorcontrib><creatorcontrib>Bartowiak, Marcin</creatorcontrib><creatorcontrib>Kornmayer, Marielouise</creatorcontrib><creatorcontrib>Brooks, Stephanie</creatorcontrib><creatorcontrib>Risse, Elena</creatorcontrib><creatorcontrib>Kathan, Susanne</creatorcontrib><creatorcontrib>Hofmann, Monika</creatorcontrib><creatorcontrib>Grebmer, Christian</creatorcontrib><creatorcontrib>Reents, Tilko</creatorcontrib><creatorcontrib>Hessling, Gabriele</creatorcontrib><creatorcontrib>Deisenhofer, Isabel</creatorcontrib><creatorcontrib>Bourier, Felix</creatorcontrib><title>Early recurrence after pulmonary vein isolation is associated with inferior long‐term outcomes: Insights from a retrospective cohort study</title><title>Pacing and clinical electrophysiology</title><addtitle>Pacing Clin Electrophysiol</addtitle><description>Aims
The aim of this retrospective cohort study was to assess the influence of early recurrence (ER) after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) on long‐term outcomes and to identify clinical variables associated with ER.
Methods
We retrospectively collected clinical and procedural data from 1285 patients with paroxysmal AF who underwent PVI from 2011 to 2016. Kaplan‐Meier, receiver operating characteristic (ROC) curve, logistic and Cox regression analyses were performed to analyze the influence of ER on long‐term outcomes.
Results
ER was observed in 13% of patients. Kaplan‐Meier analyses showed significantly different outcomes in 1285 patients with and without ER (49% vs 74%, log rank P < .01) and in 286 patients in the subgroup that underwent reablation (44% vs 79%, log rank P < .01). The hazard ratio (HR) of ER was 1.7 within 48 hours (5% of patients), 2.7 within 1 month (5%), 3.0 within 2 months (2%), and 6.4 within 3 months (1%) for late recurrence (LR), P < .01. ROC analysis (area under the curve [AUC] = 0.79) resulted in 70.3% sensitivity and 74.2% specificity for a 14‐day blanking period, and 53.1% sensitivity and 85.5% specificity for a 30‐day blanking period. Female patients (odds ratio [OR] 1.69, P < .01) and those with diabetes (OR 1.95, P = .01) were at higher risk for ER.
Conclusions
ER is observed in a substantial number of patients with paroxysmal AF after PVI and has a continuous direct effect on LR according to the timing of ER. Randomized trials are required to assess the safety and effects of reablations in a shortened blanking period on long‐term outcomes.</description><subject>atrial fibrillation</subject><subject>blanking period</subject><subject>Cardiac arrhythmia</subject><subject>catheter ablation</subject><subject>Clinical trials</subject><subject>Cohort analysis</subject><subject>Diabetes mellitus</subject><subject>early recurrence</subject><subject>Fibrillation</subject><issn>0147-8389</issn><issn>1540-8159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp90ctOGzEUBmCrKiqBdtMHqCx1UyFNenybS3coSiFSJFiwHznOmcRoZjy1PaDs-gAseMY-CQ4BFizqjb34_PvyE_KVwZSl8XPQBqdMQg4fyIQpCVnJVPWRTIDJIitFWR2TkxBuARKR6hM5FrysVJXDhDzMtW931KMZvcfeINVNRE-Hse1cr_2O3qHtqQ2u1dG6_YrqEJyxOuKa3tu4pbZv0Fvnaev6zb-_j2l_R90Yjesw_KKLPtjNNgbaeNdRnc6K3oUBTbR3SI3bOh9piON695kcNboN-OVlPiU3v-c3s8tseXWxmJ0vMyNUARlj2khYoZJKMLYywHMjV1zkKucaoTElA5OjRiEUaM1zVVSs4rwBAWqdi1Py4xA7ePdnxBDrzgaDbat7dGOouZRQAa8Knuj3d_TWjb5Pl0tKMak4l0VSZwdl0sOCx6YevO3S59UM6n1F9b6i-rmihL-9RI6rDtdv9LWTBNgB3NsWd_-Jqq_PZ_ND6BNFxZ53</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Kalinsek, Tine Prolic</creator><creator>Kottmaier, Marc</creator><creator>Telishevska, Marta</creator><creator>Berger, Florian</creator><creator>Semmler, Verena</creator><creator>Popa, Miruna</creator><creator>Brkic, Amir</creator><creator>Lengauer, Sarah</creator><creator>Otgonbayar, Ulamnemekh</creator><creator>Koch‐Büttner, Katharina</creator><creator>Bartowiak, Marcin</creator><creator>Kornmayer, Marielouise</creator><creator>Brooks, Stephanie</creator><creator>Risse, Elena</creator><creator>Kathan, Susanne</creator><creator>Hofmann, Monika</creator><creator>Grebmer, Christian</creator><creator>Reents, Tilko</creator><creator>Hessling, Gabriele</creator><creator>Deisenhofer, Isabel</creator><creator>Bourier, Felix</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>NAPCQ</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4861-6595</orcidid><orcidid>https://orcid.org/0000-0002-7742-5598</orcidid></search><sort><creationdate>202010</creationdate><title>Early recurrence after pulmonary vein isolation is associated with inferior long‐term outcomes: Insights from a retrospective cohort study</title><author>Kalinsek, Tine Prolic ; Kottmaier, Marc ; Telishevska, Marta ; Berger, Florian ; Semmler, Verena ; Popa, Miruna ; Brkic, Amir ; Lengauer, Sarah ; Otgonbayar, Ulamnemekh ; Koch‐Büttner, Katharina ; Bartowiak, Marcin ; Kornmayer, Marielouise ; Brooks, Stephanie ; Risse, Elena ; Kathan, Susanne ; Hofmann, Monika ; Grebmer, Christian ; Reents, Tilko ; Hessling, Gabriele ; Deisenhofer, Isabel ; Bourier, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3570-11ac40be545311bc026c4b236562ae0fc810c6eae3350aa265791922f0305d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>atrial fibrillation</topic><topic>blanking period</topic><topic>Cardiac arrhythmia</topic><topic>catheter ablation</topic><topic>Clinical trials</topic><topic>Cohort analysis</topic><topic>Diabetes mellitus</topic><topic>early recurrence</topic><topic>Fibrillation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kalinsek, Tine Prolic</creatorcontrib><creatorcontrib>Kottmaier, Marc</creatorcontrib><creatorcontrib>Telishevska, Marta</creatorcontrib><creatorcontrib>Berger, Florian</creatorcontrib><creatorcontrib>Semmler, Verena</creatorcontrib><creatorcontrib>Popa, Miruna</creatorcontrib><creatorcontrib>Brkic, Amir</creatorcontrib><creatorcontrib>Lengauer, Sarah</creatorcontrib><creatorcontrib>Otgonbayar, Ulamnemekh</creatorcontrib><creatorcontrib>Koch‐Büttner, Katharina</creatorcontrib><creatorcontrib>Bartowiak, Marcin</creatorcontrib><creatorcontrib>Kornmayer, Marielouise</creatorcontrib><creatorcontrib>Brooks, Stephanie</creatorcontrib><creatorcontrib>Risse, Elena</creatorcontrib><creatorcontrib>Kathan, Susanne</creatorcontrib><creatorcontrib>Hofmann, Monika</creatorcontrib><creatorcontrib>Grebmer, Christian</creatorcontrib><creatorcontrib>Reents, Tilko</creatorcontrib><creatorcontrib>Hessling, Gabriele</creatorcontrib><creatorcontrib>Deisenhofer, Isabel</creatorcontrib><creatorcontrib>Bourier, Felix</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pacing and clinical electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kalinsek, Tine Prolic</au><au>Kottmaier, Marc</au><au>Telishevska, Marta</au><au>Berger, Florian</au><au>Semmler, Verena</au><au>Popa, Miruna</au><au>Brkic, Amir</au><au>Lengauer, Sarah</au><au>Otgonbayar, Ulamnemekh</au><au>Koch‐Büttner, Katharina</au><au>Bartowiak, Marcin</au><au>Kornmayer, Marielouise</au><au>Brooks, Stephanie</au><au>Risse, Elena</au><au>Kathan, Susanne</au><au>Hofmann, Monika</au><au>Grebmer, Christian</au><au>Reents, Tilko</au><au>Hessling, Gabriele</au><au>Deisenhofer, Isabel</au><au>Bourier, Felix</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early recurrence after pulmonary vein isolation is associated with inferior long‐term outcomes: Insights from a retrospective cohort study</atitle><jtitle>Pacing and clinical electrophysiology</jtitle><addtitle>Pacing Clin Electrophysiol</addtitle><date>2020-10</date><risdate>2020</risdate><volume>43</volume><issue>10</issue><spage>1156</spage><epage>1164</epage><pages>1156-1164</pages><issn>0147-8389</issn><eissn>1540-8159</eissn><abstract>Aims
The aim of this retrospective cohort study was to assess the influence of early recurrence (ER) after pulmonary vein isolation (PVI) for paroxysmal atrial fibrillation (AF) on long‐term outcomes and to identify clinical variables associated with ER.
Methods
We retrospectively collected clinical and procedural data from 1285 patients with paroxysmal AF who underwent PVI from 2011 to 2016. Kaplan‐Meier, receiver operating characteristic (ROC) curve, logistic and Cox regression analyses were performed to analyze the influence of ER on long‐term outcomes.
Results
ER was observed in 13% of patients. Kaplan‐Meier analyses showed significantly different outcomes in 1285 patients with and without ER (49% vs 74%, log rank P < .01) and in 286 patients in the subgroup that underwent reablation (44% vs 79%, log rank P < .01). The hazard ratio (HR) of ER was 1.7 within 48 hours (5% of patients), 2.7 within 1 month (5%), 3.0 within 2 months (2%), and 6.4 within 3 months (1%) for late recurrence (LR), P < .01. ROC analysis (area under the curve [AUC] = 0.79) resulted in 70.3% sensitivity and 74.2% specificity for a 14‐day blanking period, and 53.1% sensitivity and 85.5% specificity for a 30‐day blanking period. Female patients (odds ratio [OR] 1.69, P < .01) and those with diabetes (OR 1.95, P = .01) were at higher risk for ER.
Conclusions
ER is observed in a substantial number of patients with paroxysmal AF after PVI and has a continuous direct effect on LR according to the timing of ER. Randomized trials are required to assess the safety and effects of reablations in a shortened blanking period on long‐term outcomes.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32895960</pmid><doi>10.1111/pace.14060</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-4861-6595</orcidid><orcidid>https://orcid.org/0000-0002-7742-5598</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0147-8389 |
| ispartof | Pacing and clinical electrophysiology, 2020-10, Vol.43 (10), p.1156-1164 |
| issn | 0147-8389 1540-8159 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2440902972 |
| source | Wiley Journals |
| subjects | atrial fibrillation blanking period Cardiac arrhythmia catheter ablation Clinical trials Cohort analysis Diabetes mellitus early recurrence Fibrillation |
| title | Early recurrence after pulmonary vein isolation is associated with inferior long‐term outcomes: Insights from a retrospective cohort study |
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