Multispecific Platinum(IV) Complex Deters Breast Cancer via Interposing Inflammation and Immunosuppression as an Inhibitor of COX‐2 and PD‐L1

Breast cancer (BC) is one of the most common malignancies in women and often accompanied by inflammatory processes. Cyclooxygenase‐2 (COX‐2) plays a vital role in the progression of BC, correlating with the expression of programmed death‐ligand 1 (PD‐L1). Overexpression of PD‐L1 contributes to the i...

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Veröffentlicht in:	Angewandte Chemie International Edition 2020-12, Vol.59 (51), p.23313-23321
Hauptverfasser:	Jin, Suxing, Muhammad, Nafees, Sun, Yuewen, Tan, Yehong, Yuan, Hao, Song, Dongfan, Guo, Zijian, Wang, Xiaoyong
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Anticancer properties Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Antitumor activity Apoptosis B7-H1 Antigen - antagonists & inhibitors B7-H1 Antigen - immunology Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - drug therapy Breast Neoplasms - immunology Cell Cycle Checkpoints - drug effects Cell Line, Tumor Cell Proliferation - drug effects Chemotherapy Cisplatin Cyclooxygenase 2 - immunology Cyclooxygenase 2 Inhibitors - chemical synthesis Cyclooxygenase 2 Inhibitors - chemistry Cyclooxygenase 2 Inhibitors - pharmacology Cytotoxicity Drug Screening Assays, Antitumor Extracellular signal-regulated kinase Female Humans Immunosuppression Immunotherapy Inflammation Inflammation - drug therapy Inflammation - immunology Kinases Ligands mechanism of action Metastases Myc protein Naproxen Organoplatinum Compounds - chemical synthesis Organoplatinum Compounds - chemistry Organoplatinum Compounds - pharmacology PD-L1 protein Phosphorylation Platinum platinum complex Prostaglandin endoperoxide synthase Toxicity
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