12α-Hydroxylated bile acid induces hepatic steatosis with dysbiosis in rats

There is an increasing need to explore the mechanism of the progression of non-alcoholic fatty liver disease. Steroid metabolism is closely linked to hepatic steatosis and steroids are excreted as bile acids (BAs). Here, we demonstrated that feeding WKAH/HkmSlc inbred rats a diet supplemented with c...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular and cell biology of lipids 2020-12, Vol.1865 (12), p.158811-158811, Article 158811
Hauptverfasser:	Lee, Ja-Young, Shimizu, Hidehisa, Hagio, Masahito, Fukiya, Satoru, Watanabe, Masamichi, Tanaka, Yasutake, Joe, Ga-Hyun, Iwaya, Hitoshi, Yoshitsugu, Reika, Kikuchi, Keidai, Tsuji, Misaki, Baba, Nanako, Nose, Takuma, Tada, Koji, Hanai, Taketo, Hori, Shota, Takeuchi, Akari, Furukawa, Yumiko, Shirouchi, Bungo, Sato, Masao, Ooka, Tadasuke, Ogura, Yoshitoshi, Hayashi, Tetsuya, Yokota, Atsushi, Ishizuka, Satoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	4β-Hydroxycholesterol Animals Bile Acids and Salts - metabolism Cholic acid Cholic Acids - metabolism Deoxycholic acid Deoxycholic Acid - metabolism Dysbiosis Dysbiosis - etiology Dysbiosis - metabolism Hydroxycholesterols - metabolism Hydroxylation Male Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - metabolism Rats Rats, Wistar Simple hepatic steatosis Taurocholic Acid - metabolism
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