Histamine depolarizes rat intracardiac ganglion neurons through the activation of TRPC non-selective cation channels

The cardiac plexus, which contains parasympathetic ganglia, plays an important role in regulating cardiac function. Histamine is known to excite intracardiac ganglion neurons, but the underlying mechanism is obscure. In the present study, therefore, the effect of histamine on rat intracardiac gangli...

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Veröffentlicht in:	European journal of pharmacology 2020-11, Vol.886, p.173536-173536, Article 173536
Hauptverfasser:	Sato, Aya, Arichi, Shiho, Kojima, Fumiaki, Hayashi, Toru, Ohba, Tatsuko, Cheung, Dennis Lawrence, Eto, Kei, Narushima, Madoka, Murakoshi, Hideji, Maruo, Yoshihiro, Kadoya, Yuichi, Nabekura, Junichi, Ishibashi, Hitoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acutely isolated neuron Animals Calcium Signaling - drug effects Female Ganglia - cytology Ganglia - drug effects Heart - drug effects Heart - innervation Histamine - pharmacology Histamine Agonists - pharmacology Histamine H1 Antagonists - pharmacology Histamine H1 receptor Ion Channels - drug effects M-current Male Meglumine - pharmacology Neurons - drug effects Parasympathetic postganglionic cell Patch-Clamp Techniques Perforated patch-clamp recording Potassium Channels - drug effects Pyridines - pharmacology Rats Rats, Wistar Triprolidine - pharmacology TRPC Cation Channels - drug effects TRPC channel Type C Phospholipases - drug effects
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