Tight Junction Structure and Function Revisited

Tight junctions (TJs) are intercellular junctions critical for building the epithelial barrier and maintaining epithelial polarity. The claudin family of membrane proteins play central roles in TJ structure and function. However, recent findings have uncovered claudin-independent aspects of TJ struc...

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Veröffentlicht in:	Trends in cell biology 2020-10, Vol.30 (10), p.805-817
Hauptverfasser:	Otani, Tetsuhisa, Furuse, Mikio
Format:	Artikel
Sprache:	eng
Schlagworte:	epithelial barrier epithelial polarity Lipids mechanical force membrane microdomain Membrane proteins Membranes Phase separation Polarity Proteins Scaffolding Structure-function relationships tight junction Tight junctions
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