Botulinum toxin injections minimally affect modelled muscle forces during gait in children with cerebral palsy
•BTX-A injections improve gait kinematics and kinetics in CP children.•BTX-A treatment has a limited effect on the muscle balance in CP children.•EMG-constrained optimization results in a less pronounced effect of BTX-A treatment. Children with cerebral palsy (CP) present altered gait patterns and e...
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Veröffentlicht in: | Gait & posture 2020-10, Vol.82, p.54-60 |
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description | •BTX-A injections improve gait kinematics and kinetics in CP children.•BTX-A treatment has a limited effect on the muscle balance in CP children.•EMG-constrained optimization results in a less pronounced effect of BTX-A treatment.
Children with cerebral palsy (CP) present altered gait patterns and electromyography (EMG) activity compared to typically developing children. To temporarily reduce muscular activity and to correct the abnormal muscle force balance, Botulinum Toxin type A (BTX-A) injections are used.
What is the effect of BTX-A injections on dynamic muscle forces during gait, when calculated using an EMG-constrained approach?.
Retrospective data of ten typically developing (TD) and fourteen children with spastic diplegic CP were used for musculoskeletal modeling and dynamic simulations of gait, before and after BTX-A treatment. Individual muscle forces were calculated using an EMG-constrained optimization, in which EMG of eight muscles was used as muscle excitation signal to constrain the muscle activation patterns. Paired t-tests were used to compare average modelled muscle forces in different phases of the gait cycle pre- and post-BTX-A, summarized in the muscle profile score. Two-sample t-tests were used to determine significant differences between TD and pre- and post-BTX-A modelled muscle forces.
For most muscles, the force was decreased in CP compared to TD children in all phases of the gait cycle, both before and after BTX-A treatment. Differences in muscle forces before and after BTX-A treatment were limited, with only few significant differences between pre- and post-BTX-A. Compared to a standard static optimization approach, imposing the EMG activity increased modelled muscle forces for most muscles.
Our findings indicate that BTX-A treatment has a limited effect on the muscle balance in CP children. Besides that, the use of EMG-constrained optimization is recommended when studying muscle balance in children with CP. |
doi_str_mv | 10.1016/j.gaitpost.2020.08.122 |
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Children with cerebral palsy (CP) present altered gait patterns and electromyography (EMG) activity compared to typically developing children. To temporarily reduce muscular activity and to correct the abnormal muscle force balance, Botulinum Toxin type A (BTX-A) injections are used.
What is the effect of BTX-A injections on dynamic muscle forces during gait, when calculated using an EMG-constrained approach?.
Retrospective data of ten typically developing (TD) and fourteen children with spastic diplegic CP were used for musculoskeletal modeling and dynamic simulations of gait, before and after BTX-A treatment. Individual muscle forces were calculated using an EMG-constrained optimization, in which EMG of eight muscles was used as muscle excitation signal to constrain the muscle activation patterns. Paired t-tests were used to compare average modelled muscle forces in different phases of the gait cycle pre- and post-BTX-A, summarized in the muscle profile score. Two-sample t-tests were used to determine significant differences between TD and pre- and post-BTX-A modelled muscle forces.
For most muscles, the force was decreased in CP compared to TD children in all phases of the gait cycle, both before and after BTX-A treatment. Differences in muscle forces before and after BTX-A treatment were limited, with only few significant differences between pre- and post-BTX-A. Compared to a standard static optimization approach, imposing the EMG activity increased modelled muscle forces for most muscles.
Our findings indicate that BTX-A treatment has a limited effect on the muscle balance in CP children. Besides that, the use of EMG-constrained optimization is recommended when studying muscle balance in children with CP.</description><identifier>ISSN: 0966-6362</identifier><identifier>EISSN: 1879-2219</identifier><identifier>DOI: 10.1016/j.gaitpost.2020.08.122</identifier><identifier>PMID: 32892101</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Botulinum toxin type A injections ; Botulinum Toxins, Type A - pharmacology ; Botulinum Toxins, Type A - therapeutic use ; Cerebral palsy ; Cerebral Palsy - drug therapy ; Child ; EMG-constrained optimization ; Female ; Gait - physiology ; Humans ; Male ; Musculoskeletal modelling ; Neuromuscular Agents - pharmacology ; Neuromuscular Agents - therapeutic use ; Retrospective Studies</subject><ispartof>Gait & posture, 2020-10, Vol.82, p.54-60</ispartof><rights>2020 The Author(s)</rights><rights>Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-17519e7bd98ca6aab3c56264421e03448f8d24b4ddae3666a9c8a60f19c25b803</citedby><cites>FETCH-LOGICAL-c416t-17519e7bd98ca6aab3c56264421e03448f8d24b4ddae3666a9c8a60f19c25b803</cites><orcidid>0000-0002-4255-8673</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.gaitpost.2020.08.122$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32892101$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wesseling, M.</creatorcontrib><creatorcontrib>Kainz, H.</creatorcontrib><creatorcontrib>Hoekstra, T.</creatorcontrib><creatorcontrib>Van Rossom, S.</creatorcontrib><creatorcontrib>Desloovere, K.</creatorcontrib><creatorcontrib>De Groote, F.</creatorcontrib><creatorcontrib>Jonkers, I.</creatorcontrib><title>Botulinum toxin injections minimally affect modelled muscle forces during gait in children with cerebral palsy</title><title>Gait & posture</title><addtitle>Gait Posture</addtitle><description>•BTX-A injections improve gait kinematics and kinetics in CP children.•BTX-A treatment has a limited effect on the muscle balance in CP children.•EMG-constrained optimization results in a less pronounced effect of BTX-A treatment.
Children with cerebral palsy (CP) present altered gait patterns and electromyography (EMG) activity compared to typically developing children. To temporarily reduce muscular activity and to correct the abnormal muscle force balance, Botulinum Toxin type A (BTX-A) injections are used.
What is the effect of BTX-A injections on dynamic muscle forces during gait, when calculated using an EMG-constrained approach?.
Retrospective data of ten typically developing (TD) and fourteen children with spastic diplegic CP were used for musculoskeletal modeling and dynamic simulations of gait, before and after BTX-A treatment. Individual muscle forces were calculated using an EMG-constrained optimization, in which EMG of eight muscles was used as muscle excitation signal to constrain the muscle activation patterns. Paired t-tests were used to compare average modelled muscle forces in different phases of the gait cycle pre- and post-BTX-A, summarized in the muscle profile score. Two-sample t-tests were used to determine significant differences between TD and pre- and post-BTX-A modelled muscle forces.
For most muscles, the force was decreased in CP compared to TD children in all phases of the gait cycle, both before and after BTX-A treatment. Differences in muscle forces before and after BTX-A treatment were limited, with only few significant differences between pre- and post-BTX-A. Compared to a standard static optimization approach, imposing the EMG activity increased modelled muscle forces for most muscles.
Our findings indicate that BTX-A treatment has a limited effect on the muscle balance in CP children. Besides that, the use of EMG-constrained optimization is recommended when studying muscle balance in children with CP.</description><subject>Botulinum toxin type A injections</subject><subject>Botulinum Toxins, Type A - pharmacology</subject><subject>Botulinum Toxins, Type A - therapeutic use</subject><subject>Cerebral palsy</subject><subject>Cerebral Palsy - drug therapy</subject><subject>Child</subject><subject>EMG-constrained optimization</subject><subject>Female</subject><subject>Gait - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Musculoskeletal modelling</subject><subject>Neuromuscular Agents - pharmacology</subject><subject>Neuromuscular Agents - therapeutic use</subject><subject>Retrospective Studies</subject><issn>0966-6362</issn><issn>1879-2219</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEtPLCEQhYnR6Pj4C4alm26BZmh6d6_GV2LiRteEhmplQsMI3Vfn38tk9G5dnaRyTp2qD6FzSmpKqLhc1a_aTeuYp5oRRmoia8rYHlpQ2XYVY7TbRwvSCVGJRrAjdJzzihDCG8kO0VHDZMfKngUKV3GavQvziKf46QJ2YQVmcjFkPLrgRu39ButhKEM8Rgveg8XjnI0HPMRkIGM7Jxde8fagEsfmzXmbIOAPN71hAwn6pD1ea583p-hgKApn33qCXm5vnq_vq8enu4frv4-V4VRMFW2XtIO2t500WmjdN2YpmOCcUSAN53KQlvGeW6uhEULozkgtyEA7w5a9JM0JutjtXaf4PkOe1OiyKcfrAHHOinFOhFi2tC1WsbOaFHNOMKh1Km-njaJEbVmrlfphrbasFZGqsC7B8--OuR_B_o_9wC2GPzsDlE__OUgqGwfBgHWp4FQ2ut86vgCvupXE</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Wesseling, M.</creator><creator>Kainz, H.</creator><creator>Hoekstra, T.</creator><creator>Van Rossom, S.</creator><creator>Desloovere, K.</creator><creator>De Groote, F.</creator><creator>Jonkers, I.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4255-8673</orcidid></search><sort><creationdate>202010</creationdate><title>Botulinum toxin injections minimally affect modelled muscle forces during gait in children with cerebral palsy</title><author>Wesseling, M. ; Kainz, H. ; Hoekstra, T. ; Van Rossom, S. ; Desloovere, K. ; De Groote, F. ; Jonkers, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-17519e7bd98ca6aab3c56264421e03448f8d24b4ddae3666a9c8a60f19c25b803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Botulinum toxin type A injections</topic><topic>Botulinum Toxins, Type A - pharmacology</topic><topic>Botulinum Toxins, Type A - therapeutic use</topic><topic>Cerebral palsy</topic><topic>Cerebral Palsy - drug therapy</topic><topic>Child</topic><topic>EMG-constrained optimization</topic><topic>Female</topic><topic>Gait - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Musculoskeletal modelling</topic><topic>Neuromuscular Agents - pharmacology</topic><topic>Neuromuscular Agents - therapeutic use</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wesseling, M.</creatorcontrib><creatorcontrib>Kainz, H.</creatorcontrib><creatorcontrib>Hoekstra, T.</creatorcontrib><creatorcontrib>Van Rossom, S.</creatorcontrib><creatorcontrib>Desloovere, K.</creatorcontrib><creatorcontrib>De Groote, F.</creatorcontrib><creatorcontrib>Jonkers, I.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Gait & posture</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wesseling, M.</au><au>Kainz, H.</au><au>Hoekstra, T.</au><au>Van Rossom, S.</au><au>Desloovere, K.</au><au>De Groote, F.</au><au>Jonkers, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Botulinum toxin injections minimally affect modelled muscle forces during gait in children with cerebral palsy</atitle><jtitle>Gait & posture</jtitle><addtitle>Gait Posture</addtitle><date>2020-10</date><risdate>2020</risdate><volume>82</volume><spage>54</spage><epage>60</epage><pages>54-60</pages><issn>0966-6362</issn><eissn>1879-2219</eissn><abstract>•BTX-A injections improve gait kinematics and kinetics in CP children.•BTX-A treatment has a limited effect on the muscle balance in CP children.•EMG-constrained optimization results in a less pronounced effect of BTX-A treatment.
Children with cerebral palsy (CP) present altered gait patterns and electromyography (EMG) activity compared to typically developing children. To temporarily reduce muscular activity and to correct the abnormal muscle force balance, Botulinum Toxin type A (BTX-A) injections are used.
What is the effect of BTX-A injections on dynamic muscle forces during gait, when calculated using an EMG-constrained approach?.
Retrospective data of ten typically developing (TD) and fourteen children with spastic diplegic CP were used for musculoskeletal modeling and dynamic simulations of gait, before and after BTX-A treatment. Individual muscle forces were calculated using an EMG-constrained optimization, in which EMG of eight muscles was used as muscle excitation signal to constrain the muscle activation patterns. Paired t-tests were used to compare average modelled muscle forces in different phases of the gait cycle pre- and post-BTX-A, summarized in the muscle profile score. Two-sample t-tests were used to determine significant differences between TD and pre- and post-BTX-A modelled muscle forces.
For most muscles, the force was decreased in CP compared to TD children in all phases of the gait cycle, both before and after BTX-A treatment. Differences in muscle forces before and after BTX-A treatment were limited, with only few significant differences between pre- and post-BTX-A. Compared to a standard static optimization approach, imposing the EMG activity increased modelled muscle forces for most muscles.
Our findings indicate that BTX-A treatment has a limited effect on the muscle balance in CP children. Besides that, the use of EMG-constrained optimization is recommended when studying muscle balance in children with CP.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>32892101</pmid><doi>10.1016/j.gaitpost.2020.08.122</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-4255-8673</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Botulinum toxin type A injections Botulinum Toxins, Type A - pharmacology Botulinum Toxins, Type A - therapeutic use Cerebral palsy Cerebral Palsy - drug therapy Child EMG-constrained optimization Female Gait - physiology Humans Male Musculoskeletal modelling Neuromuscular Agents - pharmacology Neuromuscular Agents - therapeutic use Retrospective Studies |
title | Botulinum toxin injections minimally affect modelled muscle forces during gait in children with cerebral palsy |
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