Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study
Background Brain-derived neurotrophic factor ( BDNF) Val66Met polymorphism is reported to be associated with cognitive dysfunction, an important comorbidity factor in patients with type 2 diabetes mellitus (T2DM), especially in elderly populations, however, the underlying pathophysiological mechanis...
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| Veröffentlicht in: | Aging clinical and experimental research 2021-06, Vol.33 (6), p.1659-1666 |
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| creator | Liu, Jia Yang, Wei Luo, Hongyu Ma, Yixin Zhao, Huan Dan, Xiaojuan |
| description | Background
Brain-derived neurotrophic factor
(
BDNF)
Val66Met polymorphism is reported to be associated with cognitive dysfunction, an important comorbidity factor in patients with type 2 diabetes mellitus (T2DM), especially in elderly populations, however, the underlying pathophysiological mechanisms are unclear.
Aim
This study was performed to investigate the association between
BDNF
Val66Met polymorphism and mild cognitive impairment (MCI) in elderly patients with T2DM.
Methods
In total, 105 MCI and 105 normal cognition controls of T2DM patients were enrolled; all of the patients underwent neuropsychological assessments.
BDNF
Val66Met polymorphism was genotyped via TaqMan SNP genotyping assay. Data from clinical and laboratory-based examinations were collected.
Results
The frequency of the
BDNF
Met allele was significantly higher in the MCI group than in the controls. Multiple regression analysis indicated an association of the Met allele with MCI in patients with T2DM (OR = 2.54; 95% CI 1.33–4.84;
p
= 0.005). Stratified by educational level, the
BDNF
Met allele was significantly associated with MCI in elderly T2DM patients (OR = 3.29; 95% CI 1.26–8.57;
p
= 0.015) among the group of low educational levels ( |
| doi_str_mv | 10.1007/s40520-020-01687-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2440664878</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2440664878</sourcerecordid><originalsourceid>FETCH-LOGICAL-c375t-618d2d41acd27befb3449d228386c1f13d4b6878dd7c1200eb8298c3817c02fa3</originalsourceid><addsrcrecordid>eNp9UcuO1TAMjRCIecAPsECR2LAp5HXbXHYwggFpEBtgG6WJO5NR2pQ45ao_xHeSqw4PsWBhObbPObZyCHnC2QvOWPcSFdsJ1rBj8FZ3zeEeOeVdLbXk-_t_vU_IGeItY4rX4iE5kULvheTqlPx4k22YGg85fAdPJ1hyKjnNN8HRwbqSMv1qY9t-hELnFNcx5TrDkQakFjG5YEvlHUK5oWOInrp0PYVSxWgYZxvyCFOhYaIQ64640tmWUFu4Uco6AxXUB9tDAXxFLXUWoXFpqlfEWKWxLH59RB4MNiI8vsvn5Mu7t58v3jdXny4_XLy-apzsdqVpufbCK26dF10PQy-V2nshtNSt4wOXXvX1o7T3neOCMei12GsnNe8cE4OV5-T5pjvn9G0BLGYM6CBGO0Fa0AilWNuqKlGhz_6B3qYlT_U6I3aKqbbTeldRYkO5nBAzDGbOYbR5NZyZo4tmc9GwYxxdNIdKenonvfQj-N-UX7ZVgNwAWEfTNeQ_u_8j-xN_4ato</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2540467885</pqid></control><display><type>article</type><title>Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Liu, Jia ; Yang, Wei ; Luo, Hongyu ; Ma, Yixin ; Zhao, Huan ; Dan, Xiaojuan</creator><creatorcontrib>Liu, Jia ; Yang, Wei ; Luo, Hongyu ; Ma, Yixin ; Zhao, Huan ; Dan, Xiaojuan</creatorcontrib><description>Background
Brain-derived neurotrophic factor
(
BDNF)
Val66Met polymorphism is reported to be associated with cognitive dysfunction, an important comorbidity factor in patients with type 2 diabetes mellitus (T2DM), especially in elderly populations, however, the underlying pathophysiological mechanisms are unclear.
Aim
This study was performed to investigate the association between
BDNF
Val66Met polymorphism and mild cognitive impairment (MCI) in elderly patients with T2DM.
Methods
In total, 105 MCI and 105 normal cognition controls of T2DM patients were enrolled; all of the patients underwent neuropsychological assessments.
BDNF
Val66Met polymorphism was genotyped via TaqMan SNP genotyping assay. Data from clinical and laboratory-based examinations were collected.
Results
The frequency of the
BDNF
Met allele was significantly higher in the MCI group than in the controls. Multiple regression analysis indicated an association of the Met allele with MCI in patients with T2DM (OR = 2.54; 95% CI 1.33–4.84;
p
= 0.005). Stratified by educational level, the
BDNF
Met allele was significantly associated with MCI in elderly T2DM patients (OR = 3.29; 95% CI 1.26–8.57;
p
= 0.015) among the group of low educational levels (< 12 years); however, the association was insignificant among those with higher educational levels.
Discussion
BDNF
Met allele carriers showed a higher frequency of MCI than Val/Val homozygotes in elderly T2DM patients. However, this association was only significant in patients with low education levels.
Conclusion
BDNF
Val66Met polymorphism may have a potential role in MCI in elderly T2DM patients, especially those with low educational levels.</description><identifier>ISSN: 1720-8319</identifier><identifier>ISSN: 1594-0667</identifier><identifier>EISSN: 1720-8319</identifier><identifier>DOI: 10.1007/s40520-020-01687-w</identifier><identifier>PMID: 32892314</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Brain-derived neurotrophic factor ; Brain-Derived Neurotrophic Factor - genetics ; Cognitive ability ; Cognitive Dysfunction - genetics ; Diabetes ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Genotype ; Geriatrics/Gerontology ; Humans ; Medicine ; Medicine & Public Health ; Neuropsychological Tests ; Original Article ; Polymorphism ; Polymorphism, Single Nucleotide</subject><ispartof>Aging clinical and experimental research, 2021-06, Vol.33 (6), p.1659-1666</ispartof><rights>Springer Nature Switzerland AG 2020</rights><rights>Springer Nature Switzerland AG 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c375t-618d2d41acd27befb3449d228386c1f13d4b6878dd7c1200eb8298c3817c02fa3</citedby><cites>FETCH-LOGICAL-c375t-618d2d41acd27befb3449d228386c1f13d4b6878dd7c1200eb8298c3817c02fa3</cites><orcidid>0000-0001-6568-3090</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40520-020-01687-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40520-020-01687-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51297</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32892314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><creatorcontrib>Luo, Hongyu</creatorcontrib><creatorcontrib>Ma, Yixin</creatorcontrib><creatorcontrib>Zhao, Huan</creatorcontrib><creatorcontrib>Dan, Xiaojuan</creatorcontrib><title>Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study</title><title>Aging clinical and experimental research</title><addtitle>Aging Clin Exp Res</addtitle><addtitle>Aging Clin Exp Res</addtitle><description>Background
Brain-derived neurotrophic factor
(
BDNF)
Val66Met polymorphism is reported to be associated with cognitive dysfunction, an important comorbidity factor in patients with type 2 diabetes mellitus (T2DM), especially in elderly populations, however, the underlying pathophysiological mechanisms are unclear.
Aim
This study was performed to investigate the association between
BDNF
Val66Met polymorphism and mild cognitive impairment (MCI) in elderly patients with T2DM.
Methods
In total, 105 MCI and 105 normal cognition controls of T2DM patients were enrolled; all of the patients underwent neuropsychological assessments.
BDNF
Val66Met polymorphism was genotyped via TaqMan SNP genotyping assay. Data from clinical and laboratory-based examinations were collected.
Results
The frequency of the
BDNF
Met allele was significantly higher in the MCI group than in the controls. Multiple regression analysis indicated an association of the Met allele with MCI in patients with T2DM (OR = 2.54; 95% CI 1.33–4.84;
p
= 0.005). Stratified by educational level, the
BDNF
Met allele was significantly associated with MCI in elderly T2DM patients (OR = 3.29; 95% CI 1.26–8.57;
p
= 0.015) among the group of low educational levels (< 12 years); however, the association was insignificant among those with higher educational levels.
Discussion
BDNF
Met allele carriers showed a higher frequency of MCI than Val/Val homozygotes in elderly T2DM patients. However, this association was only significant in patients with low education levels.
Conclusion
BDNF
Val66Met polymorphism may have a potential role in MCI in elderly T2DM patients, especially those with low educational levels.</description><subject>Aged</subject><subject>Brain-derived neurotrophic factor</subject><subject>Brain-Derived Neurotrophic Factor - genetics</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - genetics</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - genetics</subject><subject>Genotype</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neuropsychological Tests</subject><subject>Original Article</subject><subject>Polymorphism</subject><subject>Polymorphism, Single Nucleotide</subject><issn>1720-8319</issn><issn>1594-0667</issn><issn>1720-8319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9UcuO1TAMjRCIecAPsECR2LAp5HXbXHYwggFpEBtgG6WJO5NR2pQ45ao_xHeSqw4PsWBhObbPObZyCHnC2QvOWPcSFdsJ1rBj8FZ3zeEeOeVdLbXk-_t_vU_IGeItY4rX4iE5kULvheTqlPx4k22YGg85fAdPJ1hyKjnNN8HRwbqSMv1qY9t-hELnFNcx5TrDkQakFjG5YEvlHUK5oWOInrp0PYVSxWgYZxvyCFOhYaIQ64640tmWUFu4Uco6AxXUB9tDAXxFLXUWoXFpqlfEWKWxLH59RB4MNiI8vsvn5Mu7t58v3jdXny4_XLy-apzsdqVpufbCK26dF10PQy-V2nshtNSt4wOXXvX1o7T3neOCMei12GsnNe8cE4OV5-T5pjvn9G0BLGYM6CBGO0Fa0AilWNuqKlGhz_6B3qYlT_U6I3aKqbbTeldRYkO5nBAzDGbOYbR5NZyZo4tmc9GwYxxdNIdKenonvfQj-N-UX7ZVgNwAWEfTNeQ_u_8j-xN_4ato</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Liu, Jia</creator><creator>Yang, Wei</creator><creator>Luo, Hongyu</creator><creator>Ma, Yixin</creator><creator>Zhao, Huan</creator><creator>Dan, Xiaojuan</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6568-3090</orcidid></search><sort><creationdate>20210601</creationdate><title>Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study</title><author>Liu, Jia ; Yang, Wei ; Luo, Hongyu ; Ma, Yixin ; Zhao, Huan ; Dan, Xiaojuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c375t-618d2d41acd27befb3449d228386c1f13d4b6878dd7c1200eb8298c3817c02fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Aged</topic><topic>Brain-derived neurotrophic factor</topic><topic>Brain-Derived Neurotrophic Factor - genetics</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - genetics</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - genetics</topic><topic>Genotype</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neuropsychological Tests</topic><topic>Original Article</topic><topic>Polymorphism</topic><topic>Polymorphism, Single Nucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Jia</creatorcontrib><creatorcontrib>Yang, Wei</creatorcontrib><creatorcontrib>Luo, Hongyu</creatorcontrib><creatorcontrib>Ma, Yixin</creatorcontrib><creatorcontrib>Zhao, Huan</creatorcontrib><creatorcontrib>Dan, Xiaojuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Aging clinical and experimental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Jia</au><au>Yang, Wei</au><au>Luo, Hongyu</au><au>Ma, Yixin</au><au>Zhao, Huan</au><au>Dan, Xiaojuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study</atitle><jtitle>Aging clinical and experimental research</jtitle><stitle>Aging Clin Exp Res</stitle><addtitle>Aging Clin Exp Res</addtitle><date>2021-06-01</date><risdate>2021</risdate><volume>33</volume><issue>6</issue><spage>1659</spage><epage>1666</epage><pages>1659-1666</pages><issn>1720-8319</issn><issn>1594-0667</issn><eissn>1720-8319</eissn><abstract>Background
Brain-derived neurotrophic factor
(
BDNF)
Val66Met polymorphism is reported to be associated with cognitive dysfunction, an important comorbidity factor in patients with type 2 diabetes mellitus (T2DM), especially in elderly populations, however, the underlying pathophysiological mechanisms are unclear.
Aim
This study was performed to investigate the association between
BDNF
Val66Met polymorphism and mild cognitive impairment (MCI) in elderly patients with T2DM.
Methods
In total, 105 MCI and 105 normal cognition controls of T2DM patients were enrolled; all of the patients underwent neuropsychological assessments.
BDNF
Val66Met polymorphism was genotyped via TaqMan SNP genotyping assay. Data from clinical and laboratory-based examinations were collected.
Results
The frequency of the
BDNF
Met allele was significantly higher in the MCI group than in the controls. Multiple regression analysis indicated an association of the Met allele with MCI in patients with T2DM (OR = 2.54; 95% CI 1.33–4.84;
p
= 0.005). Stratified by educational level, the
BDNF
Met allele was significantly associated with MCI in elderly T2DM patients (OR = 3.29; 95% CI 1.26–8.57;
p
= 0.015) among the group of low educational levels (< 12 years); however, the association was insignificant among those with higher educational levels.
Discussion
BDNF
Met allele carriers showed a higher frequency of MCI than Val/Val homozygotes in elderly T2DM patients. However, this association was only significant in patients with low education levels.
Conclusion
BDNF
Val66Met polymorphism may have a potential role in MCI in elderly T2DM patients, especially those with low educational levels.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>32892314</pmid><doi>10.1007/s40520-020-01687-w</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-6568-3090</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1720-8319 |
| ispartof | Aging clinical and experimental research, 2021-06, Vol.33 (6), p.1659-1666 |
| issn | 1720-8319 1594-0667 1720-8319 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Aged Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor - genetics Cognitive ability Cognitive Dysfunction - genetics Diabetes Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Genotype Geriatrics/Gerontology Humans Medicine Medicine & Public Health Neuropsychological Tests Original Article Polymorphism Polymorphism, Single Nucleotide |
| title | Brain-derived neurotrophic factor Val66Met polymorphism is associated with mild cognitive impairment in elderly patients with type 2 diabetes: a case-controlled study |
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