The Anxiolytic Effect of the Neuropeptide Cycloprolylglycine Is Mediated by AMPA and TrkB Receptors

Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA rec...

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Veröffentlicht in:	Doklady. Biochemistry and biophysics 2020-07, Vol.493 (1), p.190-192
Hauptverfasser:	Gudasheva, T. A., Povarnina, P. Yu, Koliasnikova, K. N., Alyaeva, A. G., Vorontsova, O. N., Seredenin, S. B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Anxiety Agents - pharmacology Anxiety Disorders - drug therapy Anxiety Disorders - metabolism Anxiety Disorders - pathology Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biophysics Brain-Derived Neurotrophic Factor - metabolism Carbazoles - pharmacology Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Indole Alkaloids - pharmacology Life Sciences Male Membrane Glycoproteins - antagonists & inhibitors Mice Mice, Inbred BALB C Molecular Biology Neuropeptides Neurotrophic factors Peptides, Cyclic - chemistry Peptides, Cyclic - pharmacology Protein-Tyrosine Kinases - antagonists & inhibitors Quinoxalines - pharmacology Receptors, AMPA - antagonists & inhibitors Trk receptors TrkB receptors α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid α-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors
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Zusammenfassung:	Previously we have shown that the neuropeptide cycloprolylglycine is an endogenous positive modulator of AMPA receptors and assumed that the pharmacological effects of CPG are associated with the brain neurotrophic factor. In this paper, we have first demonstrated that DNQX, an inhibitor of AMPA receptors, and K252A, an ihibitor of Trk receptors, prevented the anxiolytic effect of CPG, which confirms the formulated hypothesis.
ISSN:	1607-6729 1608-3091
DOI:	10.1134/S1607672920040067