Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics
Mother’s milk contains complex microbial communities thought to be important for colonizing a preterm infant’s gastrointestinal tract. However, little is known about the microbiota in the preterm mother’s milk and factors influencing its composition. We characterized the temporal dynamics of microbi...
Gespeichert in:
| Veröffentlicht in: | Cell host & microbe 2020-11, Vol.28 (5), p.669-682.e4 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 682.e4 |
|---|---|
| container_issue | 5 |
| container_start_page | 669 |
| container_title | Cell host & microbe |
| container_volume | 28 |
| creator | Asbury, Michelle R. Butcher, James Copeland, Julia K. Unger, Sharon Bando, Nicole Comelli, Elena M. Forte, Victoria Kiss, Alex LeMay-Nedjelski, Lauren Sherman, Philip M. Stintzi, Alain Tomlinson, Christopher Wang, Pauline W. O’Connor, Deborah L. |
| description | Mother’s milk contains complex microbial communities thought to be important for colonizing a preterm infant’s gastrointestinal tract. However, little is known about the microbiota in the preterm mother’s milk and factors influencing its composition. We characterized the temporal dynamics of microbial communities in 490 breast milk samples from 86 mothers of preterm infants (born |
| doi_str_mv | 10.1016/j.chom.2020.08.001 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2440471447</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1931312820304248</els_id><sourcerecordid>2440471447</sourcerecordid><originalsourceid>FETCH-LOGICAL-c377t-730feceda47a564d8385420e6aad8222a9db49f5cf7d975949694e8dcb6bd76e3</originalsourceid><addsrcrecordid>eNp9UMtOwzAQjBBIQOEHOPnIJcF2nDiRuEDFS6KCA5ytrb2hLklcbLcSXPh1XMqZy-6ONDPamSw7Y7RglNUXy0Iv3FBwymlBm4JStpcdsbYUeU3rdv_3ZnnJeHOYHYewpLSqqGRH2ffMxQX6QFxHnj1G9AN5GDsYYyD3sMEEjN1Ys4befqEh1x4hRDKz_Xsa2ru5dRFIXEAk0wWMbxjICw4r56HvP8k1hCRyI5lBsh6h35I86ARsiFaHk-yggz7g6d-eZK-3Ny_T-_zx6e5hevWY61LKmMuSdqjRgJBQ1cI0ZVMJTrEGMA3nHFozF21X6U6aVlataOtWYGP0vJ4bWWM5yc53vivvPtYYohps0Nj3MKJbB8WFoEIyIWSi8h01pQvBY6dW3g7gPxWjatu2Wqpt22rbtqKNSm0n0eVOhCnExqJXQVsc08vWo47KOPuf_AfrwYri</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2440471447</pqid></control><display><type>article</type><title>Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics</title><source>Open Access: Cell Press Free Archives</source><source>Elsevier ScienceDirect Journals</source><source>EZB Electronic Journals Library</source><creator>Asbury, Michelle R. ; Butcher, James ; Copeland, Julia K. ; Unger, Sharon ; Bando, Nicole ; Comelli, Elena M. ; Forte, Victoria ; Kiss, Alex ; LeMay-Nedjelski, Lauren ; Sherman, Philip M. ; Stintzi, Alain ; Tomlinson, Christopher ; Wang, Pauline W. ; O’Connor, Deborah L.</creator><creatorcontrib>Asbury, Michelle R. ; Butcher, James ; Copeland, Julia K. ; Unger, Sharon ; Bando, Nicole ; Comelli, Elena M. ; Forte, Victoria ; Kiss, Alex ; LeMay-Nedjelski, Lauren ; Sherman, Philip M. ; Stintzi, Alain ; Tomlinson, Christopher ; Wang, Pauline W. ; O’Connor, Deborah L.</creatorcontrib><description>Mother’s milk contains complex microbial communities thought to be important for colonizing a preterm infant’s gastrointestinal tract. However, little is known about the microbiota in the preterm mother’s milk and factors influencing its composition. We characterized the temporal dynamics of microbial communities in 490 breast milk samples from 86 mothers of preterm infants (born <1,250g) over the first 8 weeks postpartum. Highly individualized microbial communities were identified in each mother’s milk that changed temporally with notable alterations in predicted microbial functions. However, pre-pregnancy BMI, delivery mode, and antibiotics were associated with changes in these microbial dynamics. Individual classes of antibiotics and their duration of exposure during prenatal and postpartum periods showed unique relationships with microbial taxa abundance and diversity in mother’s milk. These results highlight the temporal complexity of the preterm mother’s milk microbiota and its relationship with maternal characteristics as well as the importance of discussing antibiotic stewardship for mothers.
[Display omitted]
•Mothers of preterm infants have individualized microbiota in their breast milk•The microbiota of preterm milk changes over time•Maternal BMI and delivery mode are related to preterm milk microbiota over time•Preterm milk microbiota differs with maternal antibiotics (class, timing, and duration)
Asbury et al. show that mothers of preterm infants have individualized microbiota in their breast milk that changes over their infants’ hospitalization. Maternal pre-pregnancy BMI, delivery mode, and maternal antibiotic use (i.e., class, timing, and duration of exposure) are also associated with longitudinal changes of the preterm breast milk microbiota.</description><identifier>ISSN: 1931-3128</identifier><identifier>EISSN: 1934-6069</identifier><identifier>DOI: 10.1016/j.chom.2020.08.001</identifier><language>eng</language><publisher>Elsevier Inc</publisher><subject>antibiotics ; BMI ; breast milk ; C-section delivery ; lactation ; microbiome ; microbiota ; preterm infant ; vaginal delivery</subject><ispartof>Cell host & microbe, 2020-11, Vol.28 (5), p.669-682.e4</ispartof><rights>2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-730feceda47a564d8385420e6aad8222a9db49f5cf7d975949694e8dcb6bd76e3</citedby><cites>FETCH-LOGICAL-c377t-730feceda47a564d8385420e6aad8222a9db49f5cf7d975949694e8dcb6bd76e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1931312820304248$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Asbury, Michelle R.</creatorcontrib><creatorcontrib>Butcher, James</creatorcontrib><creatorcontrib>Copeland, Julia K.</creatorcontrib><creatorcontrib>Unger, Sharon</creatorcontrib><creatorcontrib>Bando, Nicole</creatorcontrib><creatorcontrib>Comelli, Elena M.</creatorcontrib><creatorcontrib>Forte, Victoria</creatorcontrib><creatorcontrib>Kiss, Alex</creatorcontrib><creatorcontrib>LeMay-Nedjelski, Lauren</creatorcontrib><creatorcontrib>Sherman, Philip M.</creatorcontrib><creatorcontrib>Stintzi, Alain</creatorcontrib><creatorcontrib>Tomlinson, Christopher</creatorcontrib><creatorcontrib>Wang, Pauline W.</creatorcontrib><creatorcontrib>O’Connor, Deborah L.</creatorcontrib><title>Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics</title><title>Cell host & microbe</title><description>Mother’s milk contains complex microbial communities thought to be important for colonizing a preterm infant’s gastrointestinal tract. However, little is known about the microbiota in the preterm mother’s milk and factors influencing its composition. We characterized the temporal dynamics of microbial communities in 490 breast milk samples from 86 mothers of preterm infants (born <1,250g) over the first 8 weeks postpartum. Highly individualized microbial communities were identified in each mother’s milk that changed temporally with notable alterations in predicted microbial functions. However, pre-pregnancy BMI, delivery mode, and antibiotics were associated with changes in these microbial dynamics. Individual classes of antibiotics and their duration of exposure during prenatal and postpartum periods showed unique relationships with microbial taxa abundance and diversity in mother’s milk. These results highlight the temporal complexity of the preterm mother’s milk microbiota and its relationship with maternal characteristics as well as the importance of discussing antibiotic stewardship for mothers.
[Display omitted]
•Mothers of preterm infants have individualized microbiota in their breast milk•The microbiota of preterm milk changes over time•Maternal BMI and delivery mode are related to preterm milk microbiota over time•Preterm milk microbiota differs with maternal antibiotics (class, timing, and duration)
Asbury et al. show that mothers of preterm infants have individualized microbiota in their breast milk that changes over their infants’ hospitalization. Maternal pre-pregnancy BMI, delivery mode, and maternal antibiotic use (i.e., class, timing, and duration of exposure) are also associated with longitudinal changes of the preterm breast milk microbiota.</description><subject>antibiotics</subject><subject>BMI</subject><subject>breast milk</subject><subject>C-section delivery</subject><subject>lactation</subject><subject>microbiome</subject><subject>microbiota</subject><subject>preterm infant</subject><subject>vaginal delivery</subject><issn>1931-3128</issn><issn>1934-6069</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9UMtOwzAQjBBIQOEHOPnIJcF2nDiRuEDFS6KCA5ytrb2hLklcbLcSXPh1XMqZy-6ONDPamSw7Y7RglNUXy0Iv3FBwymlBm4JStpcdsbYUeU3rdv_3ZnnJeHOYHYewpLSqqGRH2ffMxQX6QFxHnj1G9AN5GDsYYyD3sMEEjN1Ys4befqEh1x4hRDKz_Xsa2ru5dRFIXEAk0wWMbxjICw4r56HvP8k1hCRyI5lBsh6h35I86ARsiFaHk-yggz7g6d-eZK-3Ny_T-_zx6e5hevWY61LKmMuSdqjRgJBQ1cI0ZVMJTrEGMA3nHFozF21X6U6aVlataOtWYGP0vJ4bWWM5yc53vivvPtYYohps0Nj3MKJbB8WFoEIyIWSi8h01pQvBY6dW3g7gPxWjatu2Wqpt22rbtqKNSm0n0eVOhCnExqJXQVsc08vWo47KOPuf_AfrwYri</recordid><startdate>20201111</startdate><enddate>20201111</enddate><creator>Asbury, Michelle R.</creator><creator>Butcher, James</creator><creator>Copeland, Julia K.</creator><creator>Unger, Sharon</creator><creator>Bando, Nicole</creator><creator>Comelli, Elena M.</creator><creator>Forte, Victoria</creator><creator>Kiss, Alex</creator><creator>LeMay-Nedjelski, Lauren</creator><creator>Sherman, Philip M.</creator><creator>Stintzi, Alain</creator><creator>Tomlinson, Christopher</creator><creator>Wang, Pauline W.</creator><creator>O’Connor, Deborah L.</creator><general>Elsevier Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20201111</creationdate><title>Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics</title><author>Asbury, Michelle R. ; Butcher, James ; Copeland, Julia K. ; Unger, Sharon ; Bando, Nicole ; Comelli, Elena M. ; Forte, Victoria ; Kiss, Alex ; LeMay-Nedjelski, Lauren ; Sherman, Philip M. ; Stintzi, Alain ; Tomlinson, Christopher ; Wang, Pauline W. ; O’Connor, Deborah L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c377t-730feceda47a564d8385420e6aad8222a9db49f5cf7d975949694e8dcb6bd76e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>antibiotics</topic><topic>BMI</topic><topic>breast milk</topic><topic>C-section delivery</topic><topic>lactation</topic><topic>microbiome</topic><topic>microbiota</topic><topic>preterm infant</topic><topic>vaginal delivery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asbury, Michelle R.</creatorcontrib><creatorcontrib>Butcher, James</creatorcontrib><creatorcontrib>Copeland, Julia K.</creatorcontrib><creatorcontrib>Unger, Sharon</creatorcontrib><creatorcontrib>Bando, Nicole</creatorcontrib><creatorcontrib>Comelli, Elena M.</creatorcontrib><creatorcontrib>Forte, Victoria</creatorcontrib><creatorcontrib>Kiss, Alex</creatorcontrib><creatorcontrib>LeMay-Nedjelski, Lauren</creatorcontrib><creatorcontrib>Sherman, Philip M.</creatorcontrib><creatorcontrib>Stintzi, Alain</creatorcontrib><creatorcontrib>Tomlinson, Christopher</creatorcontrib><creatorcontrib>Wang, Pauline W.</creatorcontrib><creatorcontrib>O’Connor, Deborah L.</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell host & microbe</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asbury, Michelle R.</au><au>Butcher, James</au><au>Copeland, Julia K.</au><au>Unger, Sharon</au><au>Bando, Nicole</au><au>Comelli, Elena M.</au><au>Forte, Victoria</au><au>Kiss, Alex</au><au>LeMay-Nedjelski, Lauren</au><au>Sherman, Philip M.</au><au>Stintzi, Alain</au><au>Tomlinson, Christopher</au><au>Wang, Pauline W.</au><au>O’Connor, Deborah L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics</atitle><jtitle>Cell host & microbe</jtitle><date>2020-11-11</date><risdate>2020</risdate><volume>28</volume><issue>5</issue><spage>669</spage><epage>682.e4</epage><pages>669-682.e4</pages><issn>1931-3128</issn><eissn>1934-6069</eissn><abstract>Mother’s milk contains complex microbial communities thought to be important for colonizing a preterm infant’s gastrointestinal tract. However, little is known about the microbiota in the preterm mother’s milk and factors influencing its composition. We characterized the temporal dynamics of microbial communities in 490 breast milk samples from 86 mothers of preterm infants (born <1,250g) over the first 8 weeks postpartum. Highly individualized microbial communities were identified in each mother’s milk that changed temporally with notable alterations in predicted microbial functions. However, pre-pregnancy BMI, delivery mode, and antibiotics were associated with changes in these microbial dynamics. Individual classes of antibiotics and their duration of exposure during prenatal and postpartum periods showed unique relationships with microbial taxa abundance and diversity in mother’s milk. These results highlight the temporal complexity of the preterm mother’s milk microbiota and its relationship with maternal characteristics as well as the importance of discussing antibiotic stewardship for mothers.
[Display omitted]
•Mothers of preterm infants have individualized microbiota in their breast milk•The microbiota of preterm milk changes over time•Maternal BMI and delivery mode are related to preterm milk microbiota over time•Preterm milk microbiota differs with maternal antibiotics (class, timing, and duration)
Asbury et al. show that mothers of preterm infants have individualized microbiota in their breast milk that changes over their infants’ hospitalization. Maternal pre-pregnancy BMI, delivery mode, and maternal antibiotic use (i.e., class, timing, and duration of exposure) are also associated with longitudinal changes of the preterm breast milk microbiota.</abstract><pub>Elsevier Inc</pub><doi>10.1016/j.chom.2020.08.001</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1931-3128 |
| ispartof | Cell host & microbe, 2020-11, Vol.28 (5), p.669-682.e4 |
| issn | 1931-3128 1934-6069 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2440471447 |
| source | Open Access: Cell Press Free Archives; Elsevier ScienceDirect Journals; EZB Electronic Journals Library |
| subjects | antibiotics BMI breast milk C-section delivery lactation microbiome microbiota preterm infant vaginal delivery |
| title | Mothers of Preterm Infants Have Individualized Breast Milk Microbiota that Changes Temporally Based on Maternal Characteristics |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-11T23%3A12%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mothers%20of%20Preterm%20Infants%20Have%20Individualized%20Breast%20Milk%20Microbiota%20that%20Changes%20Temporally%20Based%20on%20Maternal%20Characteristics&rft.jtitle=Cell%20host%20&%20microbe&rft.au=Asbury,%20Michelle%20R.&rft.date=2020-11-11&rft.volume=28&rft.issue=5&rft.spage=669&rft.epage=682.e4&rft.pages=669-682.e4&rft.issn=1931-3128&rft.eissn=1934-6069&rft_id=info:doi/10.1016/j.chom.2020.08.001&rft_dat=%3Cproquest_cross%3E2440471447%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2440471447&rft_id=info:pmid/&rft_els_id=S1931312820304248&rfr_iscdi=true |