Diet Diurnally Regulates Small Intestinal Microbiome-Epithelial-Immune Homeostasis and Enteritis

Throughout a 24-h period, the small intestine (SI) is exposed to diurnally varying food- and microbiome-derived antigenic burdens but maintains a strict immune homeostasis, which when perturbed in genetically susceptible individuals, may lead to Crohn disease. Herein, we demonstrate that dietary con...

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Veröffentlicht in:	Cell 2020-09, Vol.182 (6), p.1441-1459.e21
Hauptverfasser:	Tuganbaev, Timur, Mor, Uria, Bashiardes, Stavros, Liwinski, Timur, Nobs, Samuel Philip, Leshem, Avner, Dori-Bachash, Mally, Thaiss, Christoph A., Pinker, Elisha Y., Ratiner, Karina, Adlung, Lorenz, Federici, Sara, Kleimeyer, Christian, Moresi, Claudia, Yamada, Takahiro, Cohen, Yotam, Zhang, Xiao, Massalha, Hassan, Massasa, Efi, Kuperman, Yael, Koni, Pandelakis A., Harmelin, Alon, Gao, Nan, Itzkovitz, Shalev, Honda, Kenya, Shapiro, Hagit, Elinav, Eran
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - pharmacology circadian clock Circadian Clocks - physiology Crohn disease Crohn Disease - immunology Crohn Disease - metabolism Crohn Disease - microbiology Diet epithelial cell Epithelial Cells - cytology Epithelial Cells - immunology Epithelial Cells - metabolism Flow Cytometry Gastrointestinal Microbiome - drug effects Gastrointestinal Microbiome - genetics Gene Expression Profiling HFD high-fat diet Histocompatibility Antigens Class II - genetics Histocompatibility Antigens Class II - metabolism Homeostasis IBD IL-10 In Situ Hybridization, Fluorescence inflammatory bowel disease interleukin-10 Interleukin-10 - metabolism Interleukin-10 - pharmacology Intestine, Small - immunology Intestine, Small - microbiology Intestine, Small - physiology Lymphocytes major histocompatibility complex Male MHC class II Mice Mice, Inbred C57BL Mice, Knockout microbiome Periodicity segmented filamentous bacteria SFB small intestine T-Lymphocytes - immunology Transcriptome - genetics Transcriptome - physiology
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