Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis
Endoscopy is a central tool for diagnosing and evaluating paediatric inflammatory bowel diseases (PIBD), but is too invasive to be frequently repeated in young children. Furthermore, it is challenging to distinguish Crohn’s disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed t...
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| Veröffentlicht in: | Scientific reports 2020-09, Vol.10 (1), p.14638-14638, Article 14638 |
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| description | Endoscopy is a central tool for diagnosing and evaluating paediatric inflammatory bowel diseases (PIBD), but is too invasive to be frequently repeated in young children. Furthermore, it is challenging to distinguish Crohn’s disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed to determine biomarkers useful for the diagnosis of PIBD. Cytokines, chemokines, and growth factors were quantified in the sera of 15 patients with CD or UC, at disease onset prior to treatment, and 26 age-matched controls. Correlation of cytokine levels with the paediatric CD activity index (PCDAI) and the paediatric UC activity index (PUCAI) was analysed. Interleukin (IL)-6, IL-13, IL-7, and vascular endothelial growth factor were higher in the CD group than in the UC group. The receiver operating characteristic curve analysis showed that IL-7 was a putative biomarker for distinguishing CD from UC (area under the curve: 0.94). Granulocyte–macrophage colony-stimulating factor was associated with PCDAI, and an IL-1 receptor antagonist, IL-6, and macrophage inflammatory protein-1β were associated with PUCAI. These findings indicate significant differences in cytokine signatures among patients with new-onset PIBD, which may improve accuracy in diagnosing PIBD. |
| doi_str_mv | 10.1038/s41598-020-71503-y |
| format | Article |
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Furthermore, it is challenging to distinguish Crohn’s disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed to determine biomarkers useful for the diagnosis of PIBD. Cytokines, chemokines, and growth factors were quantified in the sera of 15 patients with CD or UC, at disease onset prior to treatment, and 26 age-matched controls. Correlation of cytokine levels with the paediatric CD activity index (PCDAI) and the paediatric UC activity index (PUCAI) was analysed. Interleukin (IL)-6, IL-13, IL-7, and vascular endothelial growth factor were higher in the CD group than in the UC group. The receiver operating characteristic curve analysis showed that IL-7 was a putative biomarker for distinguishing CD from UC (area under the curve: 0.94). Granulocyte–macrophage colony-stimulating factor was associated with PCDAI, and an IL-1 receptor antagonist, IL-6, and macrophage inflammatory protein-1β were associated with PUCAI. These findings indicate significant differences in cytokine signatures among patients with new-onset PIBD, which may improve accuracy in diagnosing PIBD.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-020-71503-y</identifier><identifier>PMID: 32884009</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/250 ; 631/250/127 ; Adolescent ; Aldehyde dehydrogenase ; Aldehyde dehydrogenase (NAD) ; Biomarkers - blood ; Body mass index ; Bone density ; Bone mineral density ; Child ; Confidence intervals ; Cytokines - blood ; Female ; Fractures ; Gene polymorphism ; Genetic factors ; Growth factors ; Hip ; Hip joint ; Humanities and Social Sciences ; Humans ; Inflammatory Bowel Diseases - blood ; Inflammatory Bowel Diseases - diagnosis ; Interleukins - blood ; Male ; multidisciplinary ; Multidisciplinary Sciences ; Osteoporosis ; Science ; Science & Technology ; Science & Technology - Other Topics ; Science (multidisciplinary) ; Severity of Illness Index ; Single-nucleotide polymorphism ; Vascular Endothelial Growth Factor A - blood</subject><ispartof>Scientific reports, 2020-09, Vol.10 (1), p.14638-14638, Article 14638</ispartof><rights>The Author(s) 2020</rights><rights>The Author(s) 2020. 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Furthermore, it is challenging to distinguish Crohn’s disease (CD) from ulcerative colitis (UC) endoscopically. This study aimed to determine biomarkers useful for the diagnosis of PIBD. Cytokines, chemokines, and growth factors were quantified in the sera of 15 patients with CD or UC, at disease onset prior to treatment, and 26 age-matched controls. Correlation of cytokine levels with the paediatric CD activity index (PCDAI) and the paediatric UC activity index (PUCAI) was analysed. Interleukin (IL)-6, IL-13, IL-7, and vascular endothelial growth factor were higher in the CD group than in the UC group. The receiver operating characteristic curve analysis showed that IL-7 was a putative biomarker for distinguishing CD from UC (area under the curve: 0.94). Granulocyte–macrophage colony-stimulating factor was associated with PCDAI, and an IL-1 receptor antagonist, IL-6, and macrophage inflammatory protein-1β were associated with PUCAI. These findings indicate significant differences in cytokine signatures among patients with new-onset PIBD, which may improve accuracy in diagnosing PIBD.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>32884009</pmid><doi>10.1038/s41598-020-71503-y</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-2409-7359</orcidid><orcidid>https://orcid.org/0000-0003-2169-0787</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 631/250 631/250/127 Adolescent Aldehyde dehydrogenase Aldehyde dehydrogenase (NAD) Biomarkers - blood Body mass index Bone density Bone mineral density Child Confidence intervals Cytokines - blood Female Fractures Gene polymorphism Genetic factors Growth factors Hip Hip joint Humanities and Social Sciences Humans Inflammatory Bowel Diseases - blood Inflammatory Bowel Diseases - diagnosis Interleukins - blood Male multidisciplinary Multidisciplinary Sciences Osteoporosis Science Science & Technology Science & Technology - Other Topics Science (multidisciplinary) Severity of Illness Index Single-nucleotide polymorphism Vascular Endothelial Growth Factor A - blood |
| title | Serological cytokine signature in paediatric patients with inflammatory bowel disease impacts diagnosis |
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