2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

[Display omitted] •Dual targeted 2-Aryl benzazole derivatives.•Compound 9m and 9n found equally active against replicating and non-replicating Mtb.•Inhibit the cell division by inhibiting GTPase activity of Mtb-FtsZ.•Capable to kill Mtb in non-replicating form by inhibiting menaquinone biosynthesis....

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Bioorganic chemistry 2020-10, Vol.103, p.104170-104170, Article 104170
Hauptverfasser:	Velappan, Anand Babu, Datta, Dhrubajyoti, Ma, Rui, Rana, Shiwani, Ghosh, Kalyan Sundar, Hari, Natarajan, Franzblau, Scott G., Debnath, Joy
Format:	Artikel
Sprache:	eng
Schlagworte:	Antitubercular Agents - pharmacology Antitubercular Agents - therapeutic use Benzazole FtsZ enzyme Humans MenG enzyme Mycobacterium tuberculosis - drug effects Tuberculosis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!