Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells
To demonstrate the anti-inflammatory activity of Aronia melanocarpa fruit extract, human bronchial epithelial cells (BEAS-2B) were treated with lipopolysaccharide (LPS) and the effects of aronia bioactive fraction (ABF(R)), anthocyanin enriched extract from the fruit of A. melanocarpa, were evaluate...
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| Veröffentlicht in: | Antioxidants 2020-09, Vol.9 (9), p.816, Article 816 |
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| description | To demonstrate the anti-inflammatory activity of Aronia melanocarpa fruit extract, human bronchial epithelial cells (BEAS-2B) were treated with lipopolysaccharide (LPS) and the effects of aronia bioactive fraction (ABF(R)), anthocyanin enriched extract from the fruit of A. melanocarpa, were evaluated. Following pretreatment with ABF(R) at 10-25 mu g /mL, BEAS-2B cells were exposed to LPS and the expression of inflammatory mediators (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, IL-8, regulated upon activation, normal T cell expressed and presumably secreted [RANTES], IL-1 beta, cyclooxygenase-2 [COX-2], and inducible nitric oxide synthase [iNOS]) was analyzed. In LPS-stimulated BEAS-2B cells, ABF(R) pretreatment significantly decreased the mRNA expression of TNF-alpha, IL-6, IL-8, RANTES, IL-1 beta, and COX-2 at doses of 10 and 25 mu g/mL. ABF(R) also attenuated the secretion of TNF- alpha, IL-6, IL-8, and RANTES protein, as demonstrated by enzyme linked immunosorbent assay. Western blot analyses revealed the decreased expression of COX-2 and iNOS following ABF(R) treatment. ROS production was decreased, and the cell cycle was arrested at the G0/G1 and S phases following ABF(R) pretreatment. Our results suggest that ABF(R) may have potential as a nutraceutical agent for the suppression of airway inflammation. |
| doi_str_mv | 10.3390/antiox9090816 |
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Following pretreatment with ABF(R) at 10-25 mu g /mL, BEAS-2B cells were exposed to LPS and the expression of inflammatory mediators (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, IL-8, regulated upon activation, normal T cell expressed and presumably secreted [RANTES], IL-1 beta, cyclooxygenase-2 [COX-2], and inducible nitric oxide synthase [iNOS]) was analyzed. In LPS-stimulated BEAS-2B cells, ABF(R) pretreatment significantly decreased the mRNA expression of TNF-alpha, IL-6, IL-8, RANTES, IL-1 beta, and COX-2 at doses of 10 and 25 mu g/mL. ABF(R) also attenuated the secretion of TNF- alpha, IL-6, IL-8, and RANTES protein, as demonstrated by enzyme linked immunosorbent assay. Western blot analyses revealed the decreased expression of COX-2 and iNOS following ABF(R) treatment. ROS production was decreased, and the cell cycle was arrested at the G0/G1 and S phases following ABF(R) pretreatment. Our results suggest that ABF(R) may have potential as a nutraceutical agent for the suppression of airway inflammation.</description><identifier>ISSN: 2076-3921</identifier><identifier>EISSN: 2076-3921</identifier><identifier>DOI: 10.3390/antiox9090816</identifier><identifier>PMID: 32887408</identifier><language>eng</language><publisher>BASEL: Mdpi</publisher><subject>Anthocyanins ; Anti-inflammatory agents ; anti-inflammatory effects ; Antibodies ; aronia bioactive fraction (ABF®) ; Aronia melanocarpa ; BEAS-2B cells ; Berries ; Biochemistry & Molecular Biology ; Cell activation ; Cell cycle ; Chemistry, Medicinal ; Chronic obstructive pulmonary disease ; Cyclooxygenase-2 ; cytokine ; Cytokines ; Enzyme-linked immunosorbent assay ; Epithelial cells ; Fluorides ; Food Science & Technology ; Fruits ; Gene expression ; IL-1β ; Inflammation ; Interleukin 6 ; Interleukin 8 ; Life Sciences & Biomedicine ; Lipopolysaccharides ; Lymphocytes T ; Nitric-oxide synthase ; Nutritional aspects ; Pharmacology & Pharmacy ; Polyphenols ; RANTES ; reactive oxygen species ; Respiratory diseases ; Respiratory tract diseases ; Rosaceae ; Science & Technology ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α</subject><ispartof>Antioxidants, 2020-09, Vol.9 (9), p.816, Article 816</ispartof><rights>COPYRIGHT 2020 MDPI AG</rights><rights>2020. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 by the authors. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>true</woscitedreferencessubscribed><woscitedreferencescount>10</woscitedreferencescount><woscitedreferencesoriginalsourcerecordid>wos000582171400001</woscitedreferencesoriginalsourcerecordid><citedby>FETCH-LOGICAL-c486t-f675063c181f3c6f4304c9d5ce8c8c3a441311b4d54a149fdccdd7bafc18f5463</citedby><cites>FETCH-LOGICAL-c486t-f675063c181f3c6f4304c9d5ce8c8c3a441311b4d54a149fdccdd7bafc18f5463</cites><orcidid>0000-0003-4393-800X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554917/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554917/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,729,782,786,866,887,2104,2116,27931,27932,28255,53798,53800</link.rule.ids></links><search><creatorcontrib>Jang, Bong-Keun</creatorcontrib><creatorcontrib>Lee, Jin-Woo</creatorcontrib><creatorcontrib>Choi, Hyun</creatorcontrib><creatorcontrib>Yim, Sung-Vin</creatorcontrib><title>Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells</title><title>Antioxidants</title><addtitle>ANTIOXIDANTS-BASEL</addtitle><description>To demonstrate the anti-inflammatory activity of Aronia melanocarpa fruit extract, human bronchial epithelial cells (BEAS-2B) were treated with lipopolysaccharide (LPS) and the effects of aronia bioactive fraction (ABF(R)), anthocyanin enriched extract from the fruit of A. melanocarpa, were evaluated. Following pretreatment with ABF(R) at 10-25 mu g /mL, BEAS-2B cells were exposed to LPS and the expression of inflammatory mediators (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, IL-8, regulated upon activation, normal T cell expressed and presumably secreted [RANTES], IL-1 beta, cyclooxygenase-2 [COX-2], and inducible nitric oxide synthase [iNOS]) was analyzed. In LPS-stimulated BEAS-2B cells, ABF(R) pretreatment significantly decreased the mRNA expression of TNF-alpha, IL-6, IL-8, RANTES, IL-1 beta, and COX-2 at doses of 10 and 25 mu g/mL. ABF(R) also attenuated the secretion of TNF- alpha, IL-6, IL-8, and RANTES protein, as demonstrated by enzyme linked immunosorbent assay. Western blot analyses revealed the decreased expression of COX-2 and iNOS following ABF(R) treatment. ROS production was decreased, and the cell cycle was arrested at the G0/G1 and S phases following ABF(R) pretreatment. Our results suggest that ABF(R) may have potential as a nutraceutical agent for the suppression of airway inflammation.</description><subject>Anthocyanins</subject><subject>Anti-inflammatory agents</subject><subject>anti-inflammatory effects</subject><subject>Antibodies</subject><subject>aronia bioactive fraction (ABF®)</subject><subject>Aronia melanocarpa</subject><subject>BEAS-2B cells</subject><subject>Berries</subject><subject>Biochemistry & Molecular Biology</subject><subject>Cell activation</subject><subject>Cell cycle</subject><subject>Chemistry, Medicinal</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Cyclooxygenase-2</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Epithelial cells</subject><subject>Fluorides</subject><subject>Food Science & Technology</subject><subject>Fruits</subject><subject>Gene expression</subject><subject>IL-1β</subject><subject>Inflammation</subject><subject>Interleukin 6</subject><subject>Interleukin 8</subject><subject>Life Sciences & Biomedicine</subject><subject>Lipopolysaccharides</subject><subject>Lymphocytes T</subject><subject>Nitric-oxide synthase</subject><subject>Nutritional aspects</subject><subject>Pharmacology & Pharmacy</subject><subject>Polyphenols</subject><subject>RANTES</subject><subject>reactive oxygen species</subject><subject>Respiratory diseases</subject><subject>Respiratory tract diseases</subject><subject>Rosaceae</subject><subject>Science & Technology</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><issn>2076-3921</issn><issn>2076-3921</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>AOWDO</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>DOA</sourceid><recordid>eNqNks9vFCEUxydGY5vao_dJvJiYUVhgBi4m201rN9lE448zefOG2WUzAyswrU3842XcplpPcuEB3_d58PgWxUtK3jKmyDtwyfofiigiaf2kOF2Qpq6YWtCnf8UnxXmMe5KHokwS9bw4YQspG07kafFzGbyzUI5mAOcRwgHKqzDZVF5YD5jsjcnrOfCuXKZk3ATJxHLz6Uu1dt2EpivXrh9gHCH5cFd-NvHgXTSldeX1NIIrL3IF3FkYysuDTTszzOHKDEN8UTzrYYjm_H4-K75dXX5dXVebjx_Wq-WmQi7rVPV1I0jNkEraM6x7zghH1Qk0EiUy4JwySlveCQ6Uq75D7LqmhT5n9ILX7KxYH7mdh70-BDtCuNMerP694cNWQ0gWB6MRieISgQiquEBQoic1tIANb9qGysx6f2QdpnY0HRqXAgyPoI9PnN3prb_RjRBc0SYDXt8Dgv8-mZj0aCPmdoAzfop6wTnhteCMZ-mrf6R7PwWXW3VUUZH_949qC_kB1vU-18UZqpd1JlGhmllVHVUYfIzB9A9XpkTPZtKPzJT18qi_Na3vI1rj0DzkZDMJuaAN5bOv6MommB2y8pNLOfXN_6eyXxww3W8</recordid><startdate>20200901</startdate><enddate>20200901</enddate><creator>Jang, Bong-Keun</creator><creator>Lee, Jin-Woo</creator><creator>Choi, Hyun</creator><creator>Yim, Sung-Vin</creator><general>Mdpi</general><general>MDPI AG</general><general>MDPI</general><scope>AOWDO</scope><scope>BLEPL</scope><scope>DTL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QR</scope><scope>7T5</scope><scope>7TO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M7P</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-4393-800X</orcidid></search><sort><creationdate>20200901</creationdate><title>Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells</title><author>Jang, Bong-Keun ; Lee, Jin-Woo ; Choi, Hyun ; Yim, Sung-Vin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-f675063c181f3c6f4304c9d5ce8c8c3a441311b4d54a149fdccdd7bafc18f5463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Anthocyanins</topic><topic>Anti-inflammatory agents</topic><topic>anti-inflammatory effects</topic><topic>Antibodies</topic><topic>aronia bioactive fraction (ABF®)</topic><topic>Aronia melanocarpa</topic><topic>BEAS-2B cells</topic><topic>Berries</topic><topic>Biochemistry & Molecular Biology</topic><topic>Cell activation</topic><topic>Cell cycle</topic><topic>Chemistry, Medicinal</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Cyclooxygenase-2</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Epithelial cells</topic><topic>Fluorides</topic><topic>Food Science & Technology</topic><topic>Fruits</topic><topic>Gene expression</topic><topic>IL-1β</topic><topic>Inflammation</topic><topic>Interleukin 6</topic><topic>Interleukin 8</topic><topic>Life Sciences & Biomedicine</topic><topic>Lipopolysaccharides</topic><topic>Lymphocytes T</topic><topic>Nitric-oxide synthase</topic><topic>Nutritional aspects</topic><topic>Pharmacology & Pharmacy</topic><topic>Polyphenols</topic><topic>RANTES</topic><topic>reactive oxygen species</topic><topic>Respiratory diseases</topic><topic>Respiratory tract diseases</topic><topic>Rosaceae</topic><topic>Science & Technology</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Bong-Keun</creatorcontrib><creatorcontrib>Lee, Jin-Woo</creatorcontrib><creatorcontrib>Choi, Hyun</creatorcontrib><creatorcontrib>Yim, Sung-Vin</creatorcontrib><collection>Web of Science - Science Citation Index Expanded - 2020</collection><collection>Web of Science Core Collection</collection><collection>Science Citation Index Expanded</collection><collection>CrossRef</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Antioxidants</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Bong-Keun</au><au>Lee, Jin-Woo</au><au>Choi, Hyun</au><au>Yim, Sung-Vin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells</atitle><jtitle>Antioxidants</jtitle><stitle>ANTIOXIDANTS-BASEL</stitle><date>2020-09-01</date><risdate>2020</risdate><volume>9</volume><issue>9</issue><spage>816</spage><pages>816-</pages><artnum>816</artnum><issn>2076-3921</issn><eissn>2076-3921</eissn><abstract>To demonstrate the anti-inflammatory activity of Aronia melanocarpa fruit extract, human bronchial epithelial cells (BEAS-2B) were treated with lipopolysaccharide (LPS) and the effects of aronia bioactive fraction (ABF(R)), anthocyanin enriched extract from the fruit of A. melanocarpa, were evaluated. Following pretreatment with ABF(R) at 10-25 mu g /mL, BEAS-2B cells were exposed to LPS and the expression of inflammatory mediators (tumor necrosis factor [TNF]-alpha, interleukin [IL]-6, IL-8, regulated upon activation, normal T cell expressed and presumably secreted [RANTES], IL-1 beta, cyclooxygenase-2 [COX-2], and inducible nitric oxide synthase [iNOS]) was analyzed. In LPS-stimulated BEAS-2B cells, ABF(R) pretreatment significantly decreased the mRNA expression of TNF-alpha, IL-6, IL-8, RANTES, IL-1 beta, and COX-2 at doses of 10 and 25 mu g/mL. ABF(R) also attenuated the secretion of TNF- alpha, IL-6, IL-8, and RANTES protein, as demonstrated by enzyme linked immunosorbent assay. Western blot analyses revealed the decreased expression of COX-2 and iNOS following ABF(R) treatment. ROS production was decreased, and the cell cycle was arrested at the G0/G1 and S phases following ABF(R) pretreatment. Our results suggest that ABF(R) may have potential as a nutraceutical agent for the suppression of airway inflammation.</abstract><cop>BASEL</cop><pub>Mdpi</pub><pmid>32887408</pmid><doi>10.3390/antiox9090816</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4393-800X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Anthocyanins Anti-inflammatory agents anti-inflammatory effects Antibodies aronia bioactive fraction (ABF®) Aronia melanocarpa BEAS-2B cells Berries Biochemistry & Molecular Biology Cell activation Cell cycle Chemistry, Medicinal Chronic obstructive pulmonary disease Cyclooxygenase-2 cytokine Cytokines Enzyme-linked immunosorbent assay Epithelial cells Fluorides Food Science & Technology Fruits Gene expression IL-1β Inflammation Interleukin 6 Interleukin 8 Life Sciences & Biomedicine Lipopolysaccharides Lymphocytes T Nitric-oxide synthase Nutritional aspects Pharmacology & Pharmacy Polyphenols RANTES reactive oxygen species Respiratory diseases Respiratory tract diseases Rosaceae Science & Technology Tumor necrosis factor-TNF Tumor necrosis factor-α |
| title | Aronia melanocarpa Fruit Bioactive Fraction Attenuates LPS-Induced Inflammatory Response in Human Bronchial Epithelial Cells |
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