Venetoclax Increases Intratumoral Effector T Cells and Antitumor Efficacy in Combination with Immune Checkpoint Blockade

The antiapoptotic protein BCL2 plays critical roles in regulating lymphocyte development and immune responses, and has also been implicated in tumorigenesis and tumor survival. However, it is unknown whether BCL2 is critical for antitumor immune responses. We evaluated whether venetoclax, a selectiv...

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Veröffentlicht in:	Cancer discovery 2021-01, Vol.11 (1), p.68-79
Hauptverfasser:	Kohlhapp, Frederick J, Haribhai, Dipica, Mathew, Rebecca, Duggan, Ryan, Ellis, Paul A, Wang, Rui, Lasater, Elisabeth A, Shi, Yan, Dave, Nimita, Riehm, Jacob J, Robinson, Valerie A, Do, An D, Li, Yijin, Orr, Christine J, Sampath, Deepak, Raval, Aparna, Merchant, Mark, Bhathena, Anahita, Salem, Ahmed Hamed, Hamel, Keith M, Leverson, Joel D, Donawho, Cherrie, Pappano, William N, Uziel, Tamar
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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