Clinical characteristics of 71 patients with coronavirus disease 2019
To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19). The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020...
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| Veröffentlicht in: | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban 2020-07, Vol.45 (7), p.790-796 |
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| container_title | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban |
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| creator | Xiao, Miaomiao Hou, Mingjie Liu, Xuhui Li, Zhe Zhao, Qingxia |
| description | To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).
The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.
Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4
and CD8
T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,
-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (
=-0.453,
>0.05), the complicates (χ
=0.042,
>0.05), and the time from symptom onset to diagnosis (
=-1.330,
>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count,
-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4
T cell count, CD8
T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all |
| doi_str_mv | 10.11817/j.issn.1672-7347.2020.200187 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_2439981475</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2439981475</sourcerecordid><originalsourceid>FETCH-LOGICAL-c1162-618736f9640b5b5e20d97ce4684320db8a09d0a5e4c874fe46e4bfea292e013d3</originalsourceid><addsrcrecordid>eNo9T8tOwzAQ9AFEq9JfQL4gcUlYPxLbR1SVh1SJC5wjx9mortKkeBMQf08QjznsjnZGox3GrgXkQlhhbg95JOpzURqZGaVNLkHCPEBYc8aW__cFWxMdAEAW4hsXbKGkNQ6sXLLtpot9DL7jYe-TDyOmSGMMxIeWG8FPfozYj8Q_4rjnYUhD799jmog3kdATcgnCXbLz1neE69-9Yq_325fNY7Z7fnja3O2yIEQps3L-TJWtKzXURV2ghMaZgLq0Ws28th5cA75AHazR7Sygrlv00kkEoRq1Yjc_uac0vE1IY3WMFLDrfI_DRJXUyjkrtClm69WvdaqP2FSnFI8-fVZ_1dUXTzNbwQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2439981475</pqid></control><display><type>article</type><title>Clinical characteristics of 71 patients with coronavirus disease 2019</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Xiao, Miaomiao ; Hou, Mingjie ; Liu, Xuhui ; Li, Zhe ; Zhao, Qingxia</creator><creatorcontrib>Xiao, Miaomiao ; Hou, Mingjie ; Liu, Xuhui ; Li, Zhe ; Zhao, Qingxia</creatorcontrib><description>To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).
The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.
Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4
and CD8
T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,
-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (
=-0.453,
>0.05), the complicates (χ
=0.042,
>0.05), and the time from symptom onset to diagnosis (
=-1.330,
>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count,
-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4
T cell count, CD8
T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all
<0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical.
The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis.</description><identifier>ISSN: 1672-7347</identifier><identifier>DOI: 10.11817/j.issn.1672-7347.2020.200187</identifier><identifier>PMID: 32879082</identifier><language>chi ; eng</language><publisher>China</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; Child ; Child, Preschool ; China ; Coronavirus Infections - diagnosis ; Coronavirus Infections - physiopathology ; Cough - virology ; COVID-19 ; Female ; Fever - virology ; Humans ; Leukocyte Count ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral - diagnosis ; Pneumonia, Viral - physiopathology ; Retrospective Studies ; SARS-CoV-2 ; Young Adult</subject><ispartof>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2020-07, Vol.45 (7), p.790-796</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1162-618736f9640b5b5e20d97ce4684320db8a09d0a5e4c874fe46e4bfea292e013d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32879082$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Miaomiao</creatorcontrib><creatorcontrib>Hou, Mingjie</creatorcontrib><creatorcontrib>Liu, Xuhui</creatorcontrib><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Zhao, Qingxia</creatorcontrib><title>Clinical characteristics of 71 patients with coronavirus disease 2019</title><title>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</title><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><description>To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).
The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.
Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4
and CD8
T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,
-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (
=-0.453,
>0.05), the complicates (χ
=0.042,
>0.05), and the time from symptom onset to diagnosis (
=-1.330,
>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count,
-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4
T cell count, CD8
T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all
<0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical.
The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Betacoronavirus</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>China</subject><subject>Coronavirus Infections - diagnosis</subject><subject>Coronavirus Infections - physiopathology</subject><subject>Cough - virology</subject><subject>COVID-19</subject><subject>Female</subject><subject>Fever - virology</subject><subject>Humans</subject><subject>Leukocyte Count</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pandemics</subject><subject>Pneumonia, Viral - diagnosis</subject><subject>Pneumonia, Viral - physiopathology</subject><subject>Retrospective Studies</subject><subject>SARS-CoV-2</subject><subject>Young Adult</subject><issn>1672-7347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9T8tOwzAQ9AFEq9JfQL4gcUlYPxLbR1SVh1SJC5wjx9mortKkeBMQf08QjznsjnZGox3GrgXkQlhhbg95JOpzURqZGaVNLkHCPEBYc8aW__cFWxMdAEAW4hsXbKGkNQ6sXLLtpot9DL7jYe-TDyOmSGMMxIeWG8FPfozYj8Q_4rjnYUhD799jmog3kdATcgnCXbLz1neE69-9Yq_325fNY7Z7fnja3O2yIEQps3L-TJWtKzXURV2ghMaZgLq0Ws28th5cA75AHazR7Sygrlv00kkEoRq1Yjc_uac0vE1IY3WMFLDrfI_DRJXUyjkrtClm69WvdaqP2FSnFI8-fVZ_1dUXTzNbwQ</recordid><startdate>20200728</startdate><enddate>20200728</enddate><creator>Xiao, Miaomiao</creator><creator>Hou, Mingjie</creator><creator>Liu, Xuhui</creator><creator>Li, Zhe</creator><creator>Zhao, Qingxia</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20200728</creationdate><title>Clinical characteristics of 71 patients with coronavirus disease 2019</title><author>Xiao, Miaomiao ; Hou, Mingjie ; Liu, Xuhui ; Li, Zhe ; Zhao, Qingxia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1162-618736f9640b5b5e20d97ce4684320db8a09d0a5e4c874fe46e4bfea292e013d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi ; eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Betacoronavirus</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>China</topic><topic>Coronavirus Infections - diagnosis</topic><topic>Coronavirus Infections - physiopathology</topic><topic>Cough - virology</topic><topic>COVID-19</topic><topic>Female</topic><topic>Fever - virology</topic><topic>Humans</topic><topic>Leukocyte Count</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pandemics</topic><topic>Pneumonia, Viral - diagnosis</topic><topic>Pneumonia, Viral - physiopathology</topic><topic>Retrospective Studies</topic><topic>SARS-CoV-2</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Miaomiao</creatorcontrib><creatorcontrib>Hou, Mingjie</creatorcontrib><creatorcontrib>Liu, Xuhui</creatorcontrib><creatorcontrib>Li, Zhe</creatorcontrib><creatorcontrib>Zhao, Qingxia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Miaomiao</au><au>Hou, Mingjie</au><au>Liu, Xuhui</au><au>Li, Zhe</au><au>Zhao, Qingxia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical characteristics of 71 patients with coronavirus disease 2019</atitle><jtitle>Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban</jtitle><addtitle>Zhong Nan Da Xue Xue Bao Yi Xue Ban</addtitle><date>2020-07-28</date><risdate>2020</risdate><volume>45</volume><issue>7</issue><spage>790</spage><epage>796</epage><pages>790-796</pages><issn>1672-7347</issn><abstract>To analyze the clinical characteristics of 71 patients with coronavirus disease 2019 (COVID-19).
The general data, epidemiological data, laboratory tests, imaging examinations, and treatment of 71 patients with COVID-19 admitted to the Sixth People's Hospital of Zhengzhou from January 19, 2020 to March 3, 2020 were retrospectively analyzed.
Of the 71 COVID-19 patients, the ages were 4-84 (41.29±15.21) years, 38 (53.5%) patients were male, 33 (46.5%) were female, and 52 (73.2%) were in 22 clusters. The main clinical manifestations were fever (78.9%), cough (64.8%), and sputum (38.0%). The fever was mainly low and moderate, with 49 patients (69.0%) at 37.3-39.0 ℃. Most of the leukocytes, neutrophils, and lymphocytes were normal, accounting for 47 (66.2%), 51 (71.8%), and 51 (71.8%) patients, respectively; a few of them were decreased, accounting for 21 (29.6%), 16 (22.5%), and 20 (28.2%) patients, respectively. There were 38 (53.5%) and 31 (43.7%) patients with the decreased CD4
and CD8
T cell counts, respectively. There were 41 (57.7%), 38 (53.5%), 32 (45.1%), 26(36.6%), 22 (31.0%), 20 (28.2%), 14 (19.7%), 14 (19.7%), and 9 (12.7%) patients with the increased levels of C-reactive protein, erythrocyte sedimentation rate, procalcitonin, fibrinogen,interleukin 6, lactate dehydrogenase,
-dimer,alanine aminotransferase, and aspartate aminotransferase, respectively. Of the 71 patients, the lung was involved in 60 (84.5%) patients, the double lung was involved in 47 (66.2%) patients, and the single lung was involved in 13 (18.3%) patients. The course of the disease was long, and the time from symptom onset to the second severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid negative transformation was (17.22±6.34) days.There were no significant differences in the incubation period (
=-0.453,
>0.05), the complicates (χ
=0.042,
>0.05), and the time from symptom onset to diagnosis (
=-1.330,
>0.05) in patients between the non-severe group and the severe group. The onset age, gender, SARS-CoV-2 nucleic acid negative time, lymphocyte count,
-dimer, C-reactive protein, total bilirubin, direct bilirubin, lactate dehydrogenase, calcium ion, CD4
T cell count, CD8
T cell count, calcitonin, procalcitonin, and troponin were significantly different between the severe group and the non-severe group (all
<0.05). Among the 71 patients, 4 (5.6%) patients were mild, 59 (83.1%) were normal, and 8 (11.3%) were severe or critical.
The aggregation phenomenon of COVID-19 is obvious. Fever and cough are the main clinical manifestations. White blood cells, neutrophils, and lymphocytes in the most patients in the early onset are normal. Most COVID-19 patients are light and ordinary type, with good prognosis.</abstract><cop>China</cop><pmid>32879082</pmid><doi>10.11817/j.issn.1672-7347.2020.200187</doi><tpages>7</tpages></addata></record> |
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| ispartof | Zhong nan da xue xue bao. Journal of Central South University. Yi xue ban, 2020-07, Vol.45 (7), p.790-796 |
| issn | 1672-7347 |
| language | chi ; eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adolescent Adult Aged Aged, 80 and over Betacoronavirus Child Child, Preschool China Coronavirus Infections - diagnosis Coronavirus Infections - physiopathology Cough - virology COVID-19 Female Fever - virology Humans Leukocyte Count Male Middle Aged Pandemics Pneumonia, Viral - diagnosis Pneumonia, Viral - physiopathology Retrospective Studies SARS-CoV-2 Young Adult |
| title | Clinical characteristics of 71 patients with coronavirus disease 2019 |
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