A “Three‐in‐One” Multifunctional Probe for Bcl‐2/Mcl‐1 Profiling and Visualizing in Situ

Bcl‐2 and Mcl‐1, the two arms of the anti‐apoptotic Bcl‐2 family proteins, have been identified as key regulators of apoptosis and effective therapeutic targets of cancer. However, no small‐molecular probe is capable of profiling and visualizing both Bcl‐2 and Mcl‐1 simultaneously in situ. Herein, w...

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Veröffentlicht in:	Chembiochem : a European journal of chemical biology 2021-01, Vol.22 (2), p.326-329
Hauptverfasser:	Zhang, Xiaodong, Wang, Ziqian, Guo, Zongwei, Song, Ting, He, Nianzhe, Zhu, Junjie, Cao, Keke, Zhang, Zhichao
Format:	Artikel
Sprache:	eng
Schlagworte:	activity-based protein profiling Apoptosis Bcl-2/Mcl-1 proteins bioimaging Fluorescence Medical imaging multifunctional probe protein labeling Regulators
Online-Zugang:	Volltext
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