Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells
Acute graft-versus-host disease (aGVHD) is caused by allo-activated donor T cells infiltrating target organs. As a regulator of immune function, granulocyte colony-stimulating factor (G-CSF) has been demonstrated to relieve the aGVHD reaction. However, the role of G-CSF-primed donor T cells in speci...
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| Veröffentlicht in: | Science China. Life sciences 2021-07, Vol.64 (7), p.1087-1096 |
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| creator | Zhou, Yang Cao, Leqing Guo, Huidong Hong, Yan Wang, Ming Wang, Ke Huang, Xiaojun Chang, Yingjun |
| description | Acute graft-versus-host disease (aGVHD) is caused by allo-activated donor T cells infiltrating target organs. As a regulator of immune function, granulocyte colony-stimulating factor (G-CSF) has been demonstrated to relieve the aGVHD reaction. However, the role of G-CSF-primed donor T cells in specific target organs is still unknown. In this study, we employed a classical MHC-mismatched transplantation mouse model (C57BL/6 into BALB/c) and found that recipient mice transplanted with G-CSF-primed T cells exhibited prolonged survival compared with that of the PBS-treated group. This protective function against GVHD mediated by G-CSF-primed donor T cells was further confirmed by decreased clinical and pathological scores in this aGVHD mouse model, especially in the lung and gut. Moreover, we found that T cells polarized towards Th2 cells and regulatory T cells were increased in specific target organs. In addition, G-CSF treatment inhibited inducible co-stimulator (ICOS) expression and increased the expression of tolerance-related genes in recipient mice. Our study provides new insight into the immune regulatory effects of G-CSF on T cell-mediated aGVHD, especially for its precise regulation in GVHD target organs. |
| doi_str_mv | 10.1007/s11427-020-1754-6 |
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As a regulator of immune function, granulocyte colony-stimulating factor (G-CSF) has been demonstrated to relieve the aGVHD reaction. However, the role of G-CSF-primed donor T cells in specific target organs is still unknown. In this study, we employed a classical MHC-mismatched transplantation mouse model (C57BL/6 into BALB/c) and found that recipient mice transplanted with G-CSF-primed T cells exhibited prolonged survival compared with that of the PBS-treated group. This protective function against GVHD mediated by G-CSF-primed donor T cells was further confirmed by decreased clinical and pathological scores in this aGVHD mouse model, especially in the lung and gut. Moreover, we found that T cells polarized towards Th2 cells and regulatory T cells were increased in specific target organs. In addition, G-CSF treatment inhibited inducible co-stimulator (ICOS) expression and increased the expression of tolerance-related genes in recipient mice. Our study provides new insight into the immune regulatory effects of G-CSF on T cell-mediated aGVHD, especially for its precise regulation in GVHD target organs.</description><identifier>ISSN: 1674-7305</identifier><identifier>EISSN: 1869-1889</identifier><identifier>DOI: 10.1007/s11427-020-1754-6</identifier><identifier>PMID: 32880861</identifier><language>eng</language><publisher>Beijing: Science China Press</publisher><subject>Animals ; Biomedical and Life Sciences ; Colonies ; Colony-stimulating factor ; Disease Models, Animal ; Graft vs Host Disease - immunology ; Graft vs Host Disease - prevention & control ; Graft-versus-host reaction ; Granulocyte colony-stimulating factor ; Granulocyte Colony-Stimulating Factor - immunology ; Granulocytes ; Helper cells ; Immune response ; Immunological tolerance ; Immunoregulation ; Leukocytes (granulocytic) ; Life Sciences ; Lymphocytes ; Lymphocytes T ; Major histocompatibility complex ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Research Paper ; T-Lymphocytes, Regulatory - immunology ; Th2 Cells - immunology ; Transplantation ; Transplantation, Homologous</subject><ispartof>Science China. Life sciences, 2021-07, Vol.64 (7), p.1087-1096</ispartof><rights>Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Science China Press and Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-b7ae8ea21d5107cc0ca4a7e72448af9ae2892daff4ae69f81f1cd7c8362f37633</citedby><cites>FETCH-LOGICAL-c372t-b7ae8ea21d5107cc0ca4a7e72448af9ae2892daff4ae69f81f1cd7c8362f37633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11427-020-1754-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11427-020-1754-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27923,27924,41487,42556,51318</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32880861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Cao, Leqing</creatorcontrib><creatorcontrib>Guo, Huidong</creatorcontrib><creatorcontrib>Hong, Yan</creatorcontrib><creatorcontrib>Wang, Ming</creatorcontrib><creatorcontrib>Wang, Ke</creatorcontrib><creatorcontrib>Huang, Xiaojun</creatorcontrib><creatorcontrib>Chang, Yingjun</creatorcontrib><title>Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells</title><title>Science China. Life sciences</title><addtitle>Sci. China Life Sci</addtitle><addtitle>Sci China Life Sci</addtitle><description>Acute graft-versus-host disease (aGVHD) is caused by allo-activated donor T cells infiltrating target organs. As a regulator of immune function, granulocyte colony-stimulating factor (G-CSF) has been demonstrated to relieve the aGVHD reaction. However, the role of G-CSF-primed donor T cells in specific target organs is still unknown. In this study, we employed a classical MHC-mismatched transplantation mouse model (C57BL/6 into BALB/c) and found that recipient mice transplanted with G-CSF-primed T cells exhibited prolonged survival compared with that of the PBS-treated group. This protective function against GVHD mediated by G-CSF-primed donor T cells was further confirmed by decreased clinical and pathological scores in this aGVHD mouse model, especially in the lung and gut. Moreover, we found that T cells polarized towards Th2 cells and regulatory T cells were increased in specific target organs. In addition, G-CSF treatment inhibited inducible co-stimulator (ICOS) expression and increased the expression of tolerance-related genes in recipient mice. Our study provides new insight into the immune regulatory effects of G-CSF on T cell-mediated aGVHD, especially for its precise regulation in GVHD target organs.</description><subject>Animals</subject><subject>Biomedical and Life Sciences</subject><subject>Colonies</subject><subject>Colony-stimulating factor</subject><subject>Disease Models, Animal</subject><subject>Graft vs Host Disease - immunology</subject><subject>Graft vs Host Disease - prevention & control</subject><subject>Graft-versus-host reaction</subject><subject>Granulocyte colony-stimulating factor</subject><subject>Granulocyte Colony-Stimulating Factor - immunology</subject><subject>Granulocytes</subject><subject>Helper cells</subject><subject>Immune response</subject><subject>Immunological tolerance</subject><subject>Immunoregulation</subject><subject>Leukocytes (granulocytic)</subject><subject>Life Sciences</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Major histocompatibility complex</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Inbred C57BL</subject><subject>Research Paper</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th2 Cells - immunology</subject><subject>Transplantation</subject><subject>Transplantation, Homologous</subject><issn>1674-7305</issn><issn>1869-1889</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc2KHCEUhYuQkBkm8wDZBCGbbJz412otw5A_GMims5bbllXtYGtFrYbOM-Uhx56aJBCICCr3O8erp-teU3JDCVHvC6WCKUwYwVRtBJbPukuqZY-p1v3ztpdKYMXJ5qK7LuWetME5YUq97C4405poSS-7X9s9Q3MKkP1PqD5F5COqkCdXUcoTxIJ8m_GYwtENj8W9QxCCO_qVTyOaoe5TSJO3ENAAB5gcOrihAU2yO6Gam88cIFYfJzS10xKSPVWHbJPFEy7VH5YAj-URbE0Zz9k3CzSkmDLaIutCKK-6FyOE4q6f1qvu-6eP29sv-O7b56-3H-6w5YpVvFPgtANGhw0lylpiQYByigmhYezBMd2zAcZRgJP9qOlI7aCs5pKNXEnOr7p3q--c04_FlWoOvpw7gOjSUgwTvO-VkJI09O0_6H1acmzdGbYRqtdEcdYoulI2p1KyG835eZBPhhJzTtOsaZqWpjmnaWTTvHlyXnbtJ_4ofmfXALYCpZXi5PLfq__v-gACDa6O</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Zhou, Yang</creator><creator>Cao, Leqing</creator><creator>Guo, Huidong</creator><creator>Hong, Yan</creator><creator>Wang, Ming</creator><creator>Wang, Ke</creator><creator>Huang, Xiaojun</creator><creator>Chang, Yingjun</creator><general>Science China Press</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>20210701</creationdate><title>Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells</title><author>Zhou, Yang ; 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Life sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhou, Yang</au><au>Cao, Leqing</au><au>Guo, Huidong</au><au>Hong, Yan</au><au>Wang, Ming</au><au>Wang, Ke</au><au>Huang, Xiaojun</au><au>Chang, Yingjun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells</atitle><jtitle>Science China. Life sciences</jtitle><stitle>Sci. China Life Sci</stitle><addtitle>Sci China Life Sci</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>64</volume><issue>7</issue><spage>1087</spage><epage>1096</epage><pages>1087-1096</pages><issn>1674-7305</issn><eissn>1869-1889</eissn><abstract>Acute graft-versus-host disease (aGVHD) is caused by allo-activated donor T cells infiltrating target organs. As a regulator of immune function, granulocyte colony-stimulating factor (G-CSF) has been demonstrated to relieve the aGVHD reaction. However, the role of G-CSF-primed donor T cells in specific target organs is still unknown. In this study, we employed a classical MHC-mismatched transplantation mouse model (C57BL/6 into BALB/c) and found that recipient mice transplanted with G-CSF-primed T cells exhibited prolonged survival compared with that of the PBS-treated group. This protective function against GVHD mediated by G-CSF-primed donor T cells was further confirmed by decreased clinical and pathological scores in this aGVHD mouse model, especially in the lung and gut. Moreover, we found that T cells polarized towards Th2 cells and regulatory T cells were increased in specific target organs. In addition, G-CSF treatment inhibited inducible co-stimulator (ICOS) expression and increased the expression of tolerance-related genes in recipient mice. Our study provides new insight into the immune regulatory effects of G-CSF on T cell-mediated aGVHD, especially for its precise regulation in GVHD target organs.</abstract><cop>Beijing</cop><pub>Science China Press</pub><pmid>32880861</pmid><doi>10.1007/s11427-020-1754-6</doi><tpages>10</tpages></addata></record> |
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| subjects | Animals Biomedical and Life Sciences Colonies Colony-stimulating factor Disease Models, Animal Graft vs Host Disease - immunology Graft vs Host Disease - prevention & control Graft-versus-host reaction Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - immunology Granulocytes Helper cells Immune response Immunological tolerance Immunoregulation Leukocytes (granulocytic) Life Sciences Lymphocytes Lymphocytes T Major histocompatibility complex Mice Mice, Inbred BALB C Mice, Inbred C57BL Research Paper T-Lymphocytes, Regulatory - immunology Th2 Cells - immunology Transplantation Transplantation, Homologous |
| title | Th2 polarization in target organs is involved in the alleviation of pathological damage mediated by transplanting granulocyte colony-stimulating factor-primed donor T cells |
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