Roles of Gut Microbiota in Pathogenesis of Alzheimer’s Disease and Therapeutic Effects of Chinese Medicine

Roles of Gut Microbiota in Pathogenesis of Alzheimer’s Disease and Therapeutic Effects of Chinese Medicine

Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota...

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Veröffentlicht in:Chinese journal of integrative medicine 2022-11, Vol.28 (11), p.1048-1056
Hauptverfasser: Sun, Ying-xin, Jiang, Xi-juan, Lu, Bin, Gao, Qing, Chen, Ye-fei, Wu, Dan-bin, Zeng, Wen-yun, Yang, Lin, Li, Hu-hu, Yu, Bin
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container_end_page 1056
container_issue 11
container_start_page 1048
container_title Chinese journal of integrative medicine
container_volume 28
creator Sun, Ying-xin
Jiang, Xi-juan
Lu, Bin
Gao, Qing
Chen, Ye-fei
Wu, Dan-bin
Zeng, Wen-yun
Yang, Lin
Li, Hu-hu
Yu, Bin
description Alzheimer’s disease (AD) is the most common neurodegenerative disease characterized by progressive cognitive impairment. The pathogenesis of AD is complex, and its susceptibility and development process are affected by age, genetic and epigenetic factors. Recent studies confirmed that gut microbiota (GM) might contribute to AD through a variety of pathways including hypothalamic pituitary adrenal axis and inflflammatory and immune processes. CM formula, herbs, and monomer enjoy unique advantages to treat and prevent AD. Hence, the purpose of this review is to outline the roles of GM and its core metabolites in the pathogenesis of AD. Research progress of CMs regarding the mechanisms of how they regulate GM to improve cognitive impairment of AD is also reviewed. The authors tried to explore new therapeutic strategies to AD based on the regulation of GM using CM.
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subjects Medicine
Medicine & Public Health
Review
title Roles of Gut Microbiota in Pathogenesis of Alzheimer’s Disease and Therapeutic Effects of Chinese Medicine
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