Mechanisms of water permeation and diffusive API release from stearyl alcohol and glyceryl behenate modified release matrices

[Display omitted] •NMR and diffusometry define wetting rates and diffusion coefficients in lipid matrices.•These parameters determine the rate limiting steps for API release.•Placebo and active containing matrices differ significantly in rate limiting steps.•A Peclet-like number is proposed to disti...

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Veröffentlicht in:	International journal of pharmaceutics 2020-11, Vol.589, p.119819-119819, Article 119819
Hauptverfasser:	Cape, Jonathan L., Pluntze, Amanda M., Nelson, Madison L., Seymour, Joseph D., Miller, Warren K., Dower, April M., Buchanan, Stephanie S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Diffusion In-vitro screening Lipid matrix NMR diffusometry Water permeation Wetting
Online-Zugang:	Volltext
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