Is there a higher risk of a complicated course of hepatitis A in kidney transplant patients?
•HAV in kidney transplant patients is associated with an increased ICU stay and liver failure, suggesting a more fulminant course of disease.•In a cohort of 106 hemodialysis patients, we found a high anti-HAV IgG prevalence of 69.8%.•This case highlights the need of scaling up preventative measures...
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| Veröffentlicht in: | Journal of clinical virology 2020-10, Vol.131, p.104610-104610, Article 104610 |
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| container_title | Journal of clinical virology |
| container_volume | 131 |
| creator | Hanssen, D.A.T. Dackus, J. Posthouwer, D. Vennema, H. van Loo, I.H.M. |
| description | •HAV in kidney transplant patients is associated with an increased ICU stay and liver failure, suggesting a more fulminant course of disease.•In a cohort of 106 hemodialysis patients, we found a high anti-HAV IgG prevalence of 69.8%.•This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates.
We describe a patient who was planned to receive a kidney transplant from his wife. Both were infected with Hepatitis A virus (HAV) two weeks prior to the planned transplantation. Due to prolonged shedding of HAV (up until 126 days) we decided to postpone the kidney transplant in order to prevent long term complications.
The main question in this case was is there a higher risk of a complicated course of HAV-infection after kidney transplantation? We discuss the need for upscale of preventative measures of HAV infections in solid organ transplant candidates.
We performed a literature study on risks of a complicated course of HAV in solid organ transplant recipients and performed a seroprevalence study on anti-HAV in a cohort of 106 hemodialysis patients.
Little is known whether HAV infection in solid organ transplant patients causes a more aggressive course of diseases. However, HAV infections in these populations are associated with increased risk of liver failure.
This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates. |
| doi_str_mv | 10.1016/j.jcv.2020.104610 |
| format | Article |
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We describe a patient who was planned to receive a kidney transplant from his wife. Both were infected with Hepatitis A virus (HAV) two weeks prior to the planned transplantation. Due to prolonged shedding of HAV (up until 126 days) we decided to postpone the kidney transplant in order to prevent long term complications.
The main question in this case was is there a higher risk of a complicated course of HAV-infection after kidney transplantation? We discuss the need for upscale of preventative measures of HAV infections in solid organ transplant candidates.
We performed a literature study on risks of a complicated course of HAV in solid organ transplant recipients and performed a seroprevalence study on anti-HAV in a cohort of 106 hemodialysis patients.
Little is known whether HAV infection in solid organ transplant patients causes a more aggressive course of diseases. However, HAV infections in these populations are associated with increased risk of liver failure.
This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2020.104610</identifier><identifier>PMID: 32871544</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Fulminant hepatitis ; Hepatitis A ; Immunity ; Kidney transplant recipient ; Solid organ transplant recipient</subject><ispartof>Journal of clinical virology, 2020-10, Vol.131, p.104610-104610, Article 104610</ispartof><rights>2020 The Author(s)</rights><rights>Copyright © 2020 The Author(s). Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c396t-4e6af34b0139e070d94a91c4978cec19ebc9c339285a81f5d85a7feed0d4cb9d3</citedby><cites>FETCH-LOGICAL-c396t-4e6af34b0139e070d94a91c4978cec19ebc9c339285a81f5d85a7feed0d4cb9d3</cites><orcidid>0000-0003-2401-2703</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jcv.2020.104610$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32871544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hanssen, D.A.T.</creatorcontrib><creatorcontrib>Dackus, J.</creatorcontrib><creatorcontrib>Posthouwer, D.</creatorcontrib><creatorcontrib>Vennema, H.</creatorcontrib><creatorcontrib>van Loo, I.H.M.</creatorcontrib><title>Is there a higher risk of a complicated course of hepatitis A in kidney transplant patients?</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>•HAV in kidney transplant patients is associated with an increased ICU stay and liver failure, suggesting a more fulminant course of disease.•In a cohort of 106 hemodialysis patients, we found a high anti-HAV IgG prevalence of 69.8%.•This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates.
We describe a patient who was planned to receive a kidney transplant from his wife. Both were infected with Hepatitis A virus (HAV) two weeks prior to the planned transplantation. Due to prolonged shedding of HAV (up until 126 days) we decided to postpone the kidney transplant in order to prevent long term complications.
The main question in this case was is there a higher risk of a complicated course of HAV-infection after kidney transplantation? We discuss the need for upscale of preventative measures of HAV infections in solid organ transplant candidates.
We performed a literature study on risks of a complicated course of HAV in solid organ transplant recipients and performed a seroprevalence study on anti-HAV in a cohort of 106 hemodialysis patients.
Little is known whether HAV infection in solid organ transplant patients causes a more aggressive course of diseases. However, HAV infections in these populations are associated with increased risk of liver failure.
This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates.</description><subject>Fulminant hepatitis</subject><subject>Hepatitis A</subject><subject>Immunity</subject><subject>Kidney transplant recipient</subject><subject>Solid organ transplant recipient</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNp9kEtPAyEUhYnR2Fr9AW4MSzdTYWAexIVpGl9JEze6MyEU7lim05kRaJP-e5m0unR1D5dzz4UPoWtKppTQ_K6e1no3TUk6nHlOyQka07JgSSby4jRqVuZJnrF0hC68rwmhGePFORqxtCxoxvkYfb56HFbgACu8sl9RYWf9GndVbOhu0zdWqwAm6q3zMPRX0Ktgg_V4hm2L19a0sMfBqdb3jWoDHq6hDf7hEp1VqvFwdawT9PH0-D5_SRZvz6_z2SLRTOQh4ZCrivEloUwAKYgRXAmquShKDZoKWGqhGRNpmamSVpmJtagADDFcL4VhE3R7yO1d970FH-TGeg1NfA10Wy9THvekIiV5tNKDVbvOeweV7J3dKLeXlMgBqqxlhCoHqPIANc7cHOO3yw2Yv4lfitFwfzBA_OTOgpNeRwIajHWggzSd_Sf-B5Knh5g</recordid><startdate>202010</startdate><enddate>202010</enddate><creator>Hanssen, D.A.T.</creator><creator>Dackus, J.</creator><creator>Posthouwer, D.</creator><creator>Vennema, H.</creator><creator>van Loo, I.H.M.</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2401-2703</orcidid></search><sort><creationdate>202010</creationdate><title>Is there a higher risk of a complicated course of hepatitis A in kidney transplant patients?</title><author>Hanssen, D.A.T. ; Dackus, J. ; Posthouwer, D. ; Vennema, H. ; van Loo, I.H.M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c396t-4e6af34b0139e070d94a91c4978cec19ebc9c339285a81f5d85a7feed0d4cb9d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Fulminant hepatitis</topic><topic>Hepatitis A</topic><topic>Immunity</topic><topic>Kidney transplant recipient</topic><topic>Solid organ transplant recipient</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hanssen, D.A.T.</creatorcontrib><creatorcontrib>Dackus, J.</creatorcontrib><creatorcontrib>Posthouwer, D.</creatorcontrib><creatorcontrib>Vennema, H.</creatorcontrib><creatorcontrib>van Loo, I.H.M.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hanssen, D.A.T.</au><au>Dackus, J.</au><au>Posthouwer, D.</au><au>Vennema, H.</au><au>van Loo, I.H.M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Is there a higher risk of a complicated course of hepatitis A in kidney transplant patients?</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2020-10</date><risdate>2020</risdate><volume>131</volume><spage>104610</spage><epage>104610</epage><pages>104610-104610</pages><artnum>104610</artnum><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>•HAV in kidney transplant patients is associated with an increased ICU stay and liver failure, suggesting a more fulminant course of disease.•In a cohort of 106 hemodialysis patients, we found a high anti-HAV IgG prevalence of 69.8%.•This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates.
We describe a patient who was planned to receive a kidney transplant from his wife. Both were infected with Hepatitis A virus (HAV) two weeks prior to the planned transplantation. Due to prolonged shedding of HAV (up until 126 days) we decided to postpone the kidney transplant in order to prevent long term complications.
The main question in this case was is there a higher risk of a complicated course of HAV-infection after kidney transplantation? We discuss the need for upscale of preventative measures of HAV infections in solid organ transplant candidates.
We performed a literature study on risks of a complicated course of HAV in solid organ transplant recipients and performed a seroprevalence study on anti-HAV in a cohort of 106 hemodialysis patients.
Little is known whether HAV infection in solid organ transplant patients causes a more aggressive course of diseases. However, HAV infections in these populations are associated with increased risk of liver failure.
This case highlights the need of scaling up preventative measures against HAV infections in solid organ transplant candidates.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32871544</pmid><doi>10.1016/j.jcv.2020.104610</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-2401-2703</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-6532 |
| ispartof | Journal of clinical virology, 2020-10, Vol.131, p.104610-104610, Article 104610 |
| issn | 1386-6532 1873-5967 |
| language | eng |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Fulminant hepatitis Hepatitis A Immunity Kidney transplant recipient Solid organ transplant recipient |
| title | Is there a higher risk of a complicated course of hepatitis A in kidney transplant patients? |
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