Role of sialidase Neu3 and ganglioside GM3 in cardiac fibroblasts activation

Cardiac fibrosis is a key physiological response to cardiac tissue injury to protect the heart from wall rupture. However, its progression increases heart stiffness, eventually causing a decrease in heart contractility. Unfortunately, to date, no efficient antifibrotic therapies are available to the...

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Veröffentlicht in:	Biochemical journal 2020-09, Vol.477 (17), p.3401-3415
Hauptverfasser:	Ghiroldi, Andrea, Piccoli, Marco, Creo, Pasquale, Cirillo, Federica, Rota, Paola, D'Imperio, Sara, Ciconte, Giuseppe, Monasky, Michelle M., Micaglio, Emanuele, Garatti, Andrea, Aureli, Massimo, Carsana, Emma Veronica, Menicanti, Lorenzo, Pappone, Carlo, Anastasia, Luigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry & Molecular Biology Fibroblasts - metabolism Fibroblasts - pathology Fibrosis G(M3) Ganglioside - metabolism Gene Expression Regulation, Enzymologic Humans Life Sciences & Biomedicine Myocardium - metabolism Myocardium - pathology Neuraminidase - biosynthesis Receptor, Transforming Growth Factor-beta Type I - metabolism Science & Technology Up-Regulation
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