Cancer‐related gene mutations and intratumoral genetic heterogeneity in human epidermal growth factor receptor 2 heterogeneous gastric cancer

Human epidermal growth factor receptor 2 (HER2) protein overexpression is associated with HER2 gene amplification, a critical driver oncogenetic change in gastric cancer. HER2 heterogeneity in advanced gastric cancer is associated with a poor prognosis and affects the clinical efficacy of trastuzuma...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pathology international 2020-11, Vol.70 (11), p.865-870
Hauptverfasser:	Kanayama, Kazuki, Imai, Hiroshi, Usugi, Eri, Matsuda, Chise, Ichishi, Masako, Hirokawa, Yoshifumi S., Watanabe, Masatoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer cancer‐related gene Epidermal growth factor ErbB-2 protein Gastric cancer Gene amplification Genes Growth factors Heterogeneity human epidermal growth factor receptor 2 heterogeneity intratumoral genetic heterogeneity Molecular modelling Monoclonal antibodies Mutation p53 Protein Receptors subclonal mutation Targeted cancer therapy Trastuzumab
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!