New Proluciferin Substrates for Human CYP4 Family Enzymes

We report the synthesis of seven new proluciferins for convenient activity determination of enzymes belonging to the cytochrome P450 (CYP) 4 family. Biotransformation of these probe substrates was monitored using each of the twelve human CYP4 family members, and eight were found to act at least on o...

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Veröffentlicht in:	Applied biochemistry and biotechnology 2021-01, Vol.193 (1), p.218-237
Hauptverfasser:	Liu, Jingyao, Machalz, David, Wolber, Gerhard, Sorensen, Erik J., Bureik, Matthias
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biotechnology Biotransformation Chemistry Chemistry and Materials Science Conformation Cytochrome P450 Cytochromes P450 Enzymes Homology Substrates
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