Plasma matrix metalloproteinase 7, CC-chemokine ligand 18, and periostin as markers for pulmonary sarcoidosis
Some patients with sarcoidosis experience worsening of pulmonary lesions. However, no biomarker has been identified that reflects pulmonary disease status in sarcoidosis. We investigated the usefulness of potential markers of pulmonary fibrosis in patients with sarcoidosis. Plasma matrix metalloprot...
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| Veröffentlicht in: | Respiratory investigation 2020-11, Vol.58 (6), p.479-487 |
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| creator | Isshiki, Takuma Matsuyama, Hisayo Yamaguchi, Tetsuo Morita, Toshisuke Ono, Junya Nunomura, Satoshi Izuhara, Kenji Sakamoto, Susumu Homma, Sakae Kishi, Kazuma |
| description | Some patients with sarcoidosis experience worsening of pulmonary lesions. However, no biomarker has been identified that reflects pulmonary disease status in sarcoidosis. We investigated the usefulness of potential markers of pulmonary fibrosis in patients with sarcoidosis.
Plasma matrix metalloproteinase 7 (MMP-7), CC-chemokine ligand 18 (CCL-18), and periostin levels were evaluated in 60 patients with sarcoidosis and 30 healthy controls; bronchoalveolar lavage fluid levels were analyzed in 22 patients with sarcoidosis. To determine the usefulness of these markers, we explored potential correlations between these markers and sarcoidosis clinical characteristics.
Plasma MMP-7, CCL-18, and periostin concentrations were significantly higher in patients with sarcoidosis than those in healthy controls. MMP-7 concentrations in plasma and bronchoalveolar lavage fluid were higher in patients with sarcoidosis with parenchymal infiltration than in those without lung lesions. Moreover, MMP-7 concentration was negatively correlated with pulmonary function.
Among these novel biomarkers, MMP-7 most precisely reflected pulmonary sarcoidosis disease status and thus, might be useful for diagnosing and evaluating sarcoidosis, particularly in patients with pulmonary parenchymal lesions. |
| doi_str_mv | 10.1016/j.resinv.2020.07.003 |
| format | Article |
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Plasma matrix metalloproteinase 7 (MMP-7), CC-chemokine ligand 18 (CCL-18), and periostin levels were evaluated in 60 patients with sarcoidosis and 30 healthy controls; bronchoalveolar lavage fluid levels were analyzed in 22 patients with sarcoidosis. To determine the usefulness of these markers, we explored potential correlations between these markers and sarcoidosis clinical characteristics.
Plasma MMP-7, CCL-18, and periostin concentrations were significantly higher in patients with sarcoidosis than those in healthy controls. MMP-7 concentrations in plasma and bronchoalveolar lavage fluid were higher in patients with sarcoidosis with parenchymal infiltration than in those without lung lesions. Moreover, MMP-7 concentration was negatively correlated with pulmonary function.
Among these novel biomarkers, MMP-7 most precisely reflected pulmonary sarcoidosis disease status and thus, might be useful for diagnosing and evaluating sarcoidosis, particularly in patients with pulmonary parenchymal lesions.</description><identifier>ISSN: 2212-5345</identifier><identifier>EISSN: 2212-5353</identifier><identifier>DOI: 10.1016/j.resinv.2020.07.003</identifier><identifier>PMID: 32868264</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Biomarkers - blood ; Bronchoalveolar Lavage Fluid ; CC-Chemokine ligand 18 ; Cell Adhesion Molecules - blood ; Chemokines, CC - blood ; Humans ; Ligands ; Matrix metalloproteinase 7 ; Matrix Metalloproteinase 7 - blood ; Periostin ; Pulmonary fibrosis ; Sarcoidosis ; Sarcoidosis, Pulmonary - diagnosis</subject><ispartof>Respiratory investigation, 2020-11, Vol.58 (6), p.479-487</ispartof><rights>2020 The Japanese Respiratory Society</rights><rights>Copyright © 2020 The Japanese Respiratory Society. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c386t-7dfefec356d95d096aabcca9bfe3122c534826a565601790ef6ea247f2c2c4273</citedby><cites>FETCH-LOGICAL-c386t-7dfefec356d95d096aabcca9bfe3122c534826a565601790ef6ea247f2c2c4273</cites><orcidid>0000-0002-1278-0943</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32868264$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Isshiki, Takuma</creatorcontrib><creatorcontrib>Matsuyama, Hisayo</creatorcontrib><creatorcontrib>Yamaguchi, Tetsuo</creatorcontrib><creatorcontrib>Morita, Toshisuke</creatorcontrib><creatorcontrib>Ono, Junya</creatorcontrib><creatorcontrib>Nunomura, Satoshi</creatorcontrib><creatorcontrib>Izuhara, Kenji</creatorcontrib><creatorcontrib>Sakamoto, Susumu</creatorcontrib><creatorcontrib>Homma, Sakae</creatorcontrib><creatorcontrib>Kishi, Kazuma</creatorcontrib><title>Plasma matrix metalloproteinase 7, CC-chemokine ligand 18, and periostin as markers for pulmonary sarcoidosis</title><title>Respiratory investigation</title><addtitle>Respir Investig</addtitle><description>Some patients with sarcoidosis experience worsening of pulmonary lesions. However, no biomarker has been identified that reflects pulmonary disease status in sarcoidosis. We investigated the usefulness of potential markers of pulmonary fibrosis in patients with sarcoidosis.
Plasma matrix metalloproteinase 7 (MMP-7), CC-chemokine ligand 18 (CCL-18), and periostin levels were evaluated in 60 patients with sarcoidosis and 30 healthy controls; bronchoalveolar lavage fluid levels were analyzed in 22 patients with sarcoidosis. To determine the usefulness of these markers, we explored potential correlations between these markers and sarcoidosis clinical characteristics.
Plasma MMP-7, CCL-18, and periostin concentrations were significantly higher in patients with sarcoidosis than those in healthy controls. MMP-7 concentrations in plasma and bronchoalveolar lavage fluid were higher in patients with sarcoidosis with parenchymal infiltration than in those without lung lesions. Moreover, MMP-7 concentration was negatively correlated with pulmonary function.
Among these novel biomarkers, MMP-7 most precisely reflected pulmonary sarcoidosis disease status and thus, might be useful for diagnosing and evaluating sarcoidosis, particularly in patients with pulmonary parenchymal lesions.</description><subject>Biomarkers - blood</subject><subject>Bronchoalveolar Lavage Fluid</subject><subject>CC-Chemokine ligand 18</subject><subject>Cell Adhesion Molecules - blood</subject><subject>Chemokines, CC - blood</subject><subject>Humans</subject><subject>Ligands</subject><subject>Matrix metalloproteinase 7</subject><subject>Matrix Metalloproteinase 7 - blood</subject><subject>Periostin</subject><subject>Pulmonary fibrosis</subject><subject>Sarcoidosis</subject><subject>Sarcoidosis, Pulmonary - diagnosis</subject><issn>2212-5345</issn><issn>2212-5353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0Eogj6Bwh5yYIEe5w4zQYJVbwkJFjA2nKdCbgkcfGkCP4eVwWWzObO4s7jHsaOpcilkPp8mUckP3zkIEDkosqFUDvsAEBCVqpS7f71RTlhU6KlSKVLKKTeZxMFMz0DXRyw_rGz1Fve2zH6T97jaLsurGIY0Q-WkFdnfD7P3Cv24c0PyDv_YoeGy9kZ3-gKow80-oFbSkviG0bibYh8te76MNj4xclGF3wTyNMR22ttRzj90UP2fH31NL_N7h9u7uaX95lTMz1mVdNii06VuqnLRtTa2oVztl60qCSAS6nS97bUpRayqgW2Gi0UVQsOXAGVOmSn270pyPsaaTS9J4ddZwcMazJQqFpDAQDJWmytLgaiiK1ZRZ-CfBkpzIa1WZota7NhbURlEus0dvJzYb3osfkb-iWbDBdbA6acHx6jIedxcNj4iG40TfD_X_gGpMuSsw</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Isshiki, Takuma</creator><creator>Matsuyama, Hisayo</creator><creator>Yamaguchi, Tetsuo</creator><creator>Morita, Toshisuke</creator><creator>Ono, Junya</creator><creator>Nunomura, Satoshi</creator><creator>Izuhara, Kenji</creator><creator>Sakamoto, Susumu</creator><creator>Homma, Sakae</creator><creator>Kishi, Kazuma</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1278-0943</orcidid></search><sort><creationdate>202011</creationdate><title>Plasma matrix metalloproteinase 7, CC-chemokine ligand 18, and periostin as markers for pulmonary sarcoidosis</title><author>Isshiki, Takuma ; Matsuyama, Hisayo ; Yamaguchi, Tetsuo ; Morita, Toshisuke ; Ono, Junya ; Nunomura, Satoshi ; Izuhara, Kenji ; Sakamoto, Susumu ; Homma, Sakae ; Kishi, Kazuma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-7dfefec356d95d096aabcca9bfe3122c534826a565601790ef6ea247f2c2c4273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Biomarkers - blood</topic><topic>Bronchoalveolar Lavage Fluid</topic><topic>CC-Chemokine ligand 18</topic><topic>Cell Adhesion Molecules - blood</topic><topic>Chemokines, CC - blood</topic><topic>Humans</topic><topic>Ligands</topic><topic>Matrix metalloproteinase 7</topic><topic>Matrix Metalloproteinase 7 - blood</topic><topic>Periostin</topic><topic>Pulmonary fibrosis</topic><topic>Sarcoidosis</topic><topic>Sarcoidosis, Pulmonary - diagnosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Isshiki, Takuma</creatorcontrib><creatorcontrib>Matsuyama, Hisayo</creatorcontrib><creatorcontrib>Yamaguchi, Tetsuo</creatorcontrib><creatorcontrib>Morita, Toshisuke</creatorcontrib><creatorcontrib>Ono, Junya</creatorcontrib><creatorcontrib>Nunomura, Satoshi</creatorcontrib><creatorcontrib>Izuhara, Kenji</creatorcontrib><creatorcontrib>Sakamoto, Susumu</creatorcontrib><creatorcontrib>Homma, Sakae</creatorcontrib><creatorcontrib>Kishi, Kazuma</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Isshiki, Takuma</au><au>Matsuyama, Hisayo</au><au>Yamaguchi, Tetsuo</au><au>Morita, Toshisuke</au><au>Ono, Junya</au><au>Nunomura, Satoshi</au><au>Izuhara, Kenji</au><au>Sakamoto, Susumu</au><au>Homma, Sakae</au><au>Kishi, Kazuma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma matrix metalloproteinase 7, CC-chemokine ligand 18, and periostin as markers for pulmonary sarcoidosis</atitle><jtitle>Respiratory investigation</jtitle><addtitle>Respir Investig</addtitle><date>2020-11</date><risdate>2020</risdate><volume>58</volume><issue>6</issue><spage>479</spage><epage>487</epage><pages>479-487</pages><issn>2212-5345</issn><eissn>2212-5353</eissn><abstract>Some patients with sarcoidosis experience worsening of pulmonary lesions. However, no biomarker has been identified that reflects pulmonary disease status in sarcoidosis. We investigated the usefulness of potential markers of pulmonary fibrosis in patients with sarcoidosis.
Plasma matrix metalloproteinase 7 (MMP-7), CC-chemokine ligand 18 (CCL-18), and periostin levels were evaluated in 60 patients with sarcoidosis and 30 healthy controls; bronchoalveolar lavage fluid levels were analyzed in 22 patients with sarcoidosis. To determine the usefulness of these markers, we explored potential correlations between these markers and sarcoidosis clinical characteristics.
Plasma MMP-7, CCL-18, and periostin concentrations were significantly higher in patients with sarcoidosis than those in healthy controls. MMP-7 concentrations in plasma and bronchoalveolar lavage fluid were higher in patients with sarcoidosis with parenchymal infiltration than in those without lung lesions. Moreover, MMP-7 concentration was negatively correlated with pulmonary function.
Among these novel biomarkers, MMP-7 most precisely reflected pulmonary sarcoidosis disease status and thus, might be useful for diagnosing and evaluating sarcoidosis, particularly in patients with pulmonary parenchymal lesions.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>32868264</pmid><doi>10.1016/j.resinv.2020.07.003</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-1278-0943</orcidid></addata></record> |
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| subjects | Biomarkers - blood Bronchoalveolar Lavage Fluid CC-Chemokine ligand 18 Cell Adhesion Molecules - blood Chemokines, CC - blood Humans Ligands Matrix metalloproteinase 7 Matrix Metalloproteinase 7 - blood Periostin Pulmonary fibrosis Sarcoidosis Sarcoidosis, Pulmonary - diagnosis |
| title | Plasma matrix metalloproteinase 7, CC-chemokine ligand 18, and periostin as markers for pulmonary sarcoidosis |
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