Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum
Emerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most presc...
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| Veröffentlicht in: | Marine environmental research 2020-10, Vol.161, p.105109-105109, Article 105109 |
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| creator | Silva, Marisa Feijão, Eduardo da Cruz de Carvalho, Ricardo Duarte, Irina A. Matos, Ana Rita Cabrita, Maria Teresa Barreiro, Aldo Lemos, Marco F.L. Novais, Sara C. Marques, João Carlos Caçador, Isabel Reis-Santos, Patrick Fonseca, Vanessa F. Duarte, Bernardo |
| description | Emerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most prescribed and found pharmaceuticals in aquatic environments. The toxicity effects of environmentally relevant concentrations of ibuprofen on primary productivity, oxidative stress and lipid metabolism of the diatom Phaeodactylum tricornutum were assessed. Diatom cultures were exposed to 0, 0.8, 3, 40, 100 and 300 μg L−1 ibuprofen concentrations, usually found in the vicinity of wastewater treatment plants and coastal environments. Higher concentrations (100 and 300 μg L−1) had a negative impact in P. triconutum growth, inhibiting the chloroplastic energy transduction in the electron transport chain resulting in lower energy reaching the PS I (r2 = −0.55, p |
| doi_str_mv | 10.1016/j.marenvres.2020.105109 |
| format | Article |
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•Higher concentrations of Ibuprofen had a severe impact on P. tricornutum growth.•Ibuprofen provoked impairments in PS II by inhibiting the chloroplastic energy transduction in the electron transport chain.•Alteration of lipid content and peroxidation resulting in the rise of membrane fluidity and damage were detected.•Mitochondrial electron transport and available energy were enhanced.•Bio-optical tools emerge as efficient non-invasive techniques for ecotoxicology.</description><identifier>ISSN: 0141-1136</identifier><identifier>EISSN: 1879-0291</identifier><identifier>DOI: 10.1016/j.marenvres.2020.105109</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Algae ; Anti-inflammatory agents ; Antioxidants ; Aquatic environment ; Biological stress ; Biomarkers ; Biota ; Canonical analysis of principal coordinates ; Carbohydrates ; Coastal areas ; Coastal environments ; Coastal zone ; Diatom ; Diatoms ; Drugs ; Ecotoxicology ; Electron transport ; Electron transport chain ; Energy ; Energy transduction ; Environmental effects ; Environmental indicators ; Fatty acids ; Ibuprofen ; Inflammation ; Lipid metabolism ; Lipid peroxidation ; Lipids ; Marine ecosystems ; Marine microorganisms ; Metabolism ; Mitochondria ; Nonsteroidal anti-inflammatory drugs ; Oxidative metabolism ; Oxidative stress ; Peroxidation ; Phaeodactylum tricornutum ; Pharmaceuticals ; Photobiology ; Pollutants ; Primary production ; Pulse amplitude modulated (PAM) fluorometry ; Toxicity ; Transduction ; Transport ; Wastewater treatment ; Wastewater treatment plants</subject><ispartof>Marine environmental research, 2020-10, Vol.161, p.105109-105109, Article 105109</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright Elsevier BV Oct 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-7b819cfb7a689f45e9955e68ef4bb28f27fd1c2b135cda770fe86f0affb901a13</citedby><cites>FETCH-LOGICAL-c403t-7b819cfb7a689f45e9955e68ef4bb28f27fd1c2b135cda770fe86f0affb901a13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0141113620305225$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids></links><search><creatorcontrib>Silva, Marisa</creatorcontrib><creatorcontrib>Feijão, Eduardo</creatorcontrib><creatorcontrib>da Cruz de Carvalho, Ricardo</creatorcontrib><creatorcontrib>Duarte, Irina A.</creatorcontrib><creatorcontrib>Matos, Ana Rita</creatorcontrib><creatorcontrib>Cabrita, Maria Teresa</creatorcontrib><creatorcontrib>Barreiro, Aldo</creatorcontrib><creatorcontrib>Lemos, Marco F.L.</creatorcontrib><creatorcontrib>Novais, Sara C.</creatorcontrib><creatorcontrib>Marques, João Carlos</creatorcontrib><creatorcontrib>Caçador, Isabel</creatorcontrib><creatorcontrib>Reis-Santos, Patrick</creatorcontrib><creatorcontrib>Fonseca, Vanessa F.</creatorcontrib><creatorcontrib>Duarte, Bernardo</creatorcontrib><title>Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum</title><title>Marine environmental research</title><description>Emerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most prescribed and found pharmaceuticals in aquatic environments. The toxicity effects of environmentally relevant concentrations of ibuprofen on primary productivity, oxidative stress and lipid metabolism of the diatom Phaeodactylum tricornutum were assessed. Diatom cultures were exposed to 0, 0.8, 3, 40, 100 and 300 μg L−1 ibuprofen concentrations, usually found in the vicinity of wastewater treatment plants and coastal environments. Higher concentrations (100 and 300 μg L−1) had a negative impact in P. triconutum growth, inhibiting the chloroplastic energy transduction in the electron transport chain resulting in lower energy reaching the PS I (r2 = −0.55, p < 0.05). In contrast, the mitochondrial electron transport and available energy increased (r2 = 0.68 and r2 = 0.85, p < 0.05 respectively), mostly due to enhancements in lipid and protein contents as opposed to reduction of carbohydrates. A general up-regulation of the antioxidant enzymes could contributed to alleviate oxidative stress resulting in the decrease of lipid peroxidation products (r2 = 0.77, p < 0.05). Canonical analysis of principal components was performed and successfully discriminated exposure groups, with optical data excelling in classifying samples to different ibuprofen concentrations, being potentially used as environmental indicators. Finally, the identified mild to severe effects of ibuprofen on diatoms are likely to be exacerbated by the sustained use of this drug worldwide, underpinning the urgency of evaluating the impacts of this pharmaceutical on coastal and marine trophic webs.
•Higher concentrations of Ibuprofen had a severe impact on P. tricornutum growth.•Ibuprofen provoked impairments in PS II by inhibiting the chloroplastic energy transduction in the electron transport chain.•Alteration of lipid content and peroxidation resulting in the rise of membrane fluidity and damage were detected.•Mitochondrial electron transport and available energy were enhanced.•Bio-optical tools emerge as efficient non-invasive techniques for ecotoxicology.</description><subject>Algae</subject><subject>Anti-inflammatory agents</subject><subject>Antioxidants</subject><subject>Aquatic environment</subject><subject>Biological stress</subject><subject>Biomarkers</subject><subject>Biota</subject><subject>Canonical analysis of principal coordinates</subject><subject>Carbohydrates</subject><subject>Coastal areas</subject><subject>Coastal environments</subject><subject>Coastal zone</subject><subject>Diatom</subject><subject>Diatoms</subject><subject>Drugs</subject><subject>Ecotoxicology</subject><subject>Electron transport</subject><subject>Electron transport chain</subject><subject>Energy</subject><subject>Energy transduction</subject><subject>Environmental effects</subject><subject>Environmental indicators</subject><subject>Fatty acids</subject><subject>Ibuprofen</subject><subject>Inflammation</subject><subject>Lipid metabolism</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Marine ecosystems</subject><subject>Marine microorganisms</subject><subject>Metabolism</subject><subject>Mitochondria</subject><subject>Nonsteroidal anti-inflammatory drugs</subject><subject>Oxidative metabolism</subject><subject>Oxidative stress</subject><subject>Peroxidation</subject><subject>Phaeodactylum tricornutum</subject><subject>Pharmaceuticals</subject><subject>Photobiology</subject><subject>Pollutants</subject><subject>Primary production</subject><subject>Pulse amplitude modulated (PAM) fluorometry</subject><subject>Toxicity</subject><subject>Transduction</subject><subject>Transport</subject><subject>Wastewater treatment</subject><subject>Wastewater treatment plants</subject><issn>0141-1136</issn><issn>1879-0291</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqFkc1r3DAQxUVpods0f0MEvfTirUa2bKu3sKQfEGgPzVlI8qjRYktbfYT6v4-XLT300tPA8HuPN_MIuQG2Bwb9h-N-0QnDU8K854yftwKYfEF2MA6yYVzCS7Jj0EED0PavyZucj4wxMYDYkdMhLi6mos280lAX85He2Vjib299WWl0tDwiDTE0uWCKftIz1aH4xgc362XRJaaVTqn-pN7UU4oOA42Bfn_UGCdtyzrXhZbkbUyhlrq8Ja-cnjNe_5lX5OHT3Y_Dl-b-2-evh9v7xnasLc1gRpDWmUH3o3SdQCmFwH5E1xnDR8cHN4HlBlphJz0MzOHYO6adM5KBhvaKvL_4bpl-VcxFLT5bnGcdMNaseNfKnnMhxg199w96jDWFLd1G9d3Yd5K1GzVcKJtizgmdOiW_vX5VwNS5CXVUf5tQ5ybUpYlNeXtR4nbvk8eksvUYLE4-oS1qiv6_Hs_h-5ka</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Silva, Marisa</creator><creator>Feijão, Eduardo</creator><creator>da Cruz de Carvalho, Ricardo</creator><creator>Duarte, Irina A.</creator><creator>Matos, Ana Rita</creator><creator>Cabrita, Maria Teresa</creator><creator>Barreiro, Aldo</creator><creator>Lemos, Marco F.L.</creator><creator>Novais, Sara C.</creator><creator>Marques, João Carlos</creator><creator>Caçador, Isabel</creator><creator>Reis-Santos, Patrick</creator><creator>Fonseca, Vanessa F.</creator><creator>Duarte, Bernardo</creator><general>Elsevier Ltd</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SN</scope><scope>7ST</scope><scope>7T5</scope><scope>7TN</scope><scope>7U7</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>M7N</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20201001</creationdate><title>Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum</title><author>Silva, Marisa ; Feijão, Eduardo ; da Cruz de Carvalho, Ricardo ; Duarte, Irina A. ; Matos, Ana Rita ; Cabrita, Maria Teresa ; Barreiro, Aldo ; Lemos, Marco F.L. ; Novais, Sara C. ; Marques, João Carlos ; Caçador, Isabel ; Reis-Santos, Patrick ; Fonseca, Vanessa F. ; Duarte, Bernardo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-7b819cfb7a689f45e9955e68ef4bb28f27fd1c2b135cda770fe86f0affb901a13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Algae</topic><topic>Anti-inflammatory agents</topic><topic>Antioxidants</topic><topic>Aquatic environment</topic><topic>Biological stress</topic><topic>Biomarkers</topic><topic>Biota</topic><topic>Canonical analysis of principal coordinates</topic><topic>Carbohydrates</topic><topic>Coastal areas</topic><topic>Coastal environments</topic><topic>Coastal zone</topic><topic>Diatom</topic><topic>Diatoms</topic><topic>Drugs</topic><topic>Ecotoxicology</topic><topic>Electron transport</topic><topic>Electron transport chain</topic><topic>Energy</topic><topic>Energy transduction</topic><topic>Environmental effects</topic><topic>Environmental indicators</topic><topic>Fatty acids</topic><topic>Ibuprofen</topic><topic>Inflammation</topic><topic>Lipid metabolism</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Marine ecosystems</topic><topic>Marine microorganisms</topic><topic>Metabolism</topic><topic>Mitochondria</topic><topic>Nonsteroidal anti-inflammatory drugs</topic><topic>Oxidative metabolism</topic><topic>Oxidative stress</topic><topic>Peroxidation</topic><topic>Phaeodactylum tricornutum</topic><topic>Pharmaceuticals</topic><topic>Photobiology</topic><topic>Pollutants</topic><topic>Primary production</topic><topic>Pulse amplitude modulated (PAM) fluorometry</topic><topic>Toxicity</topic><topic>Transduction</topic><topic>Transport</topic><topic>Wastewater treatment</topic><topic>Wastewater treatment plants</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Silva, Marisa</creatorcontrib><creatorcontrib>Feijão, Eduardo</creatorcontrib><creatorcontrib>da Cruz de Carvalho, Ricardo</creatorcontrib><creatorcontrib>Duarte, Irina A.</creatorcontrib><creatorcontrib>Matos, Ana Rita</creatorcontrib><creatorcontrib>Cabrita, Maria Teresa</creatorcontrib><creatorcontrib>Barreiro, Aldo</creatorcontrib><creatorcontrib>Lemos, Marco F.L.</creatorcontrib><creatorcontrib>Novais, Sara C.</creatorcontrib><creatorcontrib>Marques, João Carlos</creatorcontrib><creatorcontrib>Caçador, Isabel</creatorcontrib><creatorcontrib>Reis-Santos, Patrick</creatorcontrib><creatorcontrib>Fonseca, Vanessa F.</creatorcontrib><creatorcontrib>Duarte, Bernardo</creatorcontrib><collection>CrossRef</collection><collection>Ecology Abstracts</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Oceanic Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Marine environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Silva, Marisa</au><au>Feijão, Eduardo</au><au>da Cruz de Carvalho, Ricardo</au><au>Duarte, Irina A.</au><au>Matos, Ana Rita</au><au>Cabrita, Maria Teresa</au><au>Barreiro, Aldo</au><au>Lemos, Marco F.L.</au><au>Novais, Sara C.</au><au>Marques, João Carlos</au><au>Caçador, Isabel</au><au>Reis-Santos, Patrick</au><au>Fonseca, Vanessa F.</au><au>Duarte, Bernardo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum</atitle><jtitle>Marine environmental research</jtitle><date>2020-10-01</date><risdate>2020</risdate><volume>161</volume><spage>105109</spage><epage>105109</epage><pages>105109-105109</pages><artnum>105109</artnum><issn>0141-1136</issn><eissn>1879-0291</eissn><abstract>Emerging pollutants such as pharmaceuticals are continuously released to aquatic environments posing a rising threat to marine ecosystems. Yet, monitoring routines and ecotoxicity data on biota worldwide for these substances are lacking. Non-steroidal anti-inflammatory drugs are among the most prescribed and found pharmaceuticals in aquatic environments. The toxicity effects of environmentally relevant concentrations of ibuprofen on primary productivity, oxidative stress and lipid metabolism of the diatom Phaeodactylum tricornutum were assessed. Diatom cultures were exposed to 0, 0.8, 3, 40, 100 and 300 μg L−1 ibuprofen concentrations, usually found in the vicinity of wastewater treatment plants and coastal environments. Higher concentrations (100 and 300 μg L−1) had a negative impact in P. triconutum growth, inhibiting the chloroplastic energy transduction in the electron transport chain resulting in lower energy reaching the PS I (r2 = −0.55, p < 0.05). In contrast, the mitochondrial electron transport and available energy increased (r2 = 0.68 and r2 = 0.85, p < 0.05 respectively), mostly due to enhancements in lipid and protein contents as opposed to reduction of carbohydrates. A general up-regulation of the antioxidant enzymes could contributed to alleviate oxidative stress resulting in the decrease of lipid peroxidation products (r2 = 0.77, p < 0.05). Canonical analysis of principal components was performed and successfully discriminated exposure groups, with optical data excelling in classifying samples to different ibuprofen concentrations, being potentially used as environmental indicators. Finally, the identified mild to severe effects of ibuprofen on diatoms are likely to be exacerbated by the sustained use of this drug worldwide, underpinning the urgency of evaluating the impacts of this pharmaceutical on coastal and marine trophic webs.
•Higher concentrations of Ibuprofen had a severe impact on P. tricornutum growth.•Ibuprofen provoked impairments in PS II by inhibiting the chloroplastic energy transduction in the electron transport chain.•Alteration of lipid content and peroxidation resulting in the rise of membrane fluidity and damage were detected.•Mitochondrial electron transport and available energy were enhanced.•Bio-optical tools emerge as efficient non-invasive techniques for ecotoxicology.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><doi>10.1016/j.marenvres.2020.105109</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | ScienceDirect Journals (5 years ago - present) |
| subjects | Algae Anti-inflammatory agents Antioxidants Aquatic environment Biological stress Biomarkers Biota Canonical analysis of principal coordinates Carbohydrates Coastal areas Coastal environments Coastal zone Diatom Diatoms Drugs Ecotoxicology Electron transport Electron transport chain Energy Energy transduction Environmental effects Environmental indicators Fatty acids Ibuprofen Inflammation Lipid metabolism Lipid peroxidation Lipids Marine ecosystems Marine microorganisms Metabolism Mitochondria Nonsteroidal anti-inflammatory drugs Oxidative metabolism Oxidative stress Peroxidation Phaeodactylum tricornutum Pharmaceuticals Photobiology Pollutants Primary production Pulse amplitude modulated (PAM) fluorometry Toxicity Transduction Transport Wastewater treatment Wastewater treatment plants |
| title | Comfortably numb: Ecotoxicity of the non-steroidal anti-inflammatory drug ibuprofen on Phaeodactylum tricornutum |
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