RalA exerts an inhibitory effect on IL-1β/IL-18 secretion by blocking NLRP3 inflammasome activation in levornidazole-treated human THP-1 macrophages

•RalA inhibits IL-1β/IL-18 secretion in levornidazole-treated THP-1 macrophages.•Small molecule levornidazole can directly bind with RalA.•The conformation of RalA might be regulated by levornidazole.•RalA/levornidazole blocks the assembly of NLRP3/ASC/pro-caspase-1 complex.•A novel biological funct...

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Veröffentlicht in:	International immunopharmacology 2020-11, Vol.88, p.106898-106898, Article 106898
Hauptverfasser:	Wang, Xingqi, Gou, Lingshan, Gao, Yuzhi, Huang, Yuqing, Kuai, Rui, Li, Yu, Wang, Yujing, Chen, Yanhong, Li, Jun, Cheng, Chao, Feng, Zhaojun, Wu, Xuefeng, Yao, Ruiqin
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioinformatics Blocking Caspase-1 Chemical compounds Conformational change Depletion IL-1β IL-1β/IL-18 Immunoprecipitation Inflammasomes Inflammation Interleukin 18 Lipopolysaccharides Macrophages Molecular dynamics NLRP3 RalA RalA protein Surface plasmon resonance THP-1 macrophages Western blotting
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