In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions
Context: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis. Objective: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute...
Gespeichert in:
| Veröffentlicht in: | Pharmaceutical biology 2018-01, Vol.56 (1), p.165-175 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 175 |
|---|---|
| container_issue | 1 |
| container_start_page | 165 |
| container_title | Pharmaceutical biology |
| container_volume | 56 |
| creator | Ortaç, Deniz Cemek, Mustafa Karaca, Turan Büyükokuroğlu, Mehmet E. Özdemir, Zafer Ö. Kocaman, Ayşe Tuba Göneş, Sadık |
| description | Context: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis.
Objective: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models.
Materials and methods: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que). Following a 60 min period, all the rats were given 1 mL of ethanol (80%). One hour after the administration of ethanol, all groups were sacrificed.
Results: At 5000 mg/kg, the extract produced (okra) no signs of toxicity in animals. Okra 500, 250, 100, Fam 20 and Que 75 inhibited ulcer formation by 81.0, 67.5, 67.0, 76.3 and 72.4%, respectively. Okra 500 significantly decreased edema, hemorrhage and inflammation scores compared with the ethanol group (p |
| doi_str_mv | 10.1080/13880209.2018.1442481 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_infor</sourceid><recordid>TN_cdi_proquest_miscellaneous_2439423161</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><doaj_id>oai_doaj_org_article_9987e4a17bba499aa2f274e52ac0c17f</doaj_id><sourcerecordid>2439423161</sourcerecordid><originalsourceid>FETCH-LOGICAL-c595t-fb181bf61236ad3364beb6409e46b7e2887c4a76a30276d60f4c2764846b22163</originalsourceid><addsrcrecordid>eNp9kk1vEzEQhlcIREvgJ4AscSmHDf5a7-4FUVV8RKrEBc7WrHecODh2a-8G9d_jkLSiHDh55Hn82GO9VfWa0SWjHX3PRNdRTvslp6xbMim57NiT6py1UtYNY-ppqQtTH6Cz6kXOW0ppI0TzvDrjfcME4_15dbsKZO_2kUCYXD17gymuMThD0Fo0E4mWxJ8JyMXlgH4Xs9nMmWA2s8cwzfkdiYHgtIEQfe3COBscCZh5QrKGPKUi2s0mZvDEY3Yx5JfVMws-46vTuqh-fP70_eprff3ty-rq8ro2Td9MtR1YxwarGBcKRiGUHHBQkvYo1dAi77rWSGgVCMpbNSpqpSmF7Eqbc6bEolodvWOErb5JbgfpTkdw-s9GTGsNaXLGo-77rkUJrB0GkH0PwC1vJTYcDDWstcX14ei6mYcdjqaMnsA_kj7uBLfR67jXignayL4ILk6CFG9nzJPeuWzQewgY56y5FL3kghV-Ub39B93GOYXyVZqLhlHJJOWFao6USTHnhPbhMYzqQ0D0fUD0ISD6FJBy7s3fkzycuk9EAT4eARdsTDv4FZMf9QR3PiabIBiXtfj_Hb8BYMfKmg</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2351041402</pqid></control><display><type>article</type><title>In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Taylor & Francis Open Access Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Ortaç, Deniz ; Cemek, Mustafa ; Karaca, Turan ; Büyükokuroğlu, Mehmet E. ; Özdemir, Zafer Ö. ; Kocaman, Ayşe Tuba ; Göneş, Sadık</creator><creatorcontrib>Ortaç, Deniz ; Cemek, Mustafa ; Karaca, Turan ; Büyükokuroğlu, Mehmet E. ; Özdemir, Zafer Ö. ; Kocaman, Ayşe Tuba ; Göneş, Sadık</creatorcontrib><description>Context: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis.
Objective: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models.
Materials and methods: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que). Following a 60 min period, all the rats were given 1 mL of ethanol (80%). One hour after the administration of ethanol, all groups were sacrificed.
Results: At 5000 mg/kg, the extract produced (okra) no signs of toxicity in animals. Okra 500, 250, 100, Fam 20 and Que 75 inhibited ulcer formation by 81.0, 67.5, 67.0, 76.3 and 72.4%, respectively. Okra 500 significantly decreased edema, hemorrhage and inflammation scores compared with the ethanol group (p < 0.05). The oxidant levels decreased significantly in the all study groups compared within ethanol group (p < 0.001). Serum β-carotene and retinol levels significantly increased 40.2 and 45.4% in the okra 500 group. In okra 500, 250 and Fam 20 groups, apoptosis significantly decreased (p < 0.001), while okra 500, 250 and Fam 20 groups showed a higher percentage of cell proliferation compared with the ethanol group (p < 0.001).
Discussion and conclusions: Our in vivo data indicate that okra has a gastroprotective effect against ethanol and could reduce the gastric ulcer as seen from biochemical and histopathological results. We suggest that okra could be a possible therapeutic antiulcer agent.</description><identifier>ISSN: 1388-0209</identifier><identifier>ISSN: 1744-5116</identifier><identifier>EISSN: 1744-5116</identifier><identifier>DOI: 10.1080/13880209.2018.1442481</identifier><identifier>PMID: 29513129</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Abelmoschus ; Abelmoschus esculentus ; Animal models ; Animals ; anti-ulcer activity ; Anti-Ulcer Agents - isolation & purification ; Anti-Ulcer Agents - pharmacology ; Anti-Ulcer Agents - therapeutic use ; Apoptosis ; beta-carotene ; Biochemistry ; Bioengineering ; blood serum ; Cell growth ; Cell proliferation ; Edema ; Ethanol ; Ethanol - toxicity ; Famotidine ; Gastric Mucosa - drug effects ; Gastric Mucosa - pathology ; gastric ulcer ; Gastritis ; Gastroprotection ; Hemorrhage ; Herbal medicine ; histopathology ; immunohistochemistry ; inflammation ; laboratory animals ; Male ; Medical research ; Medicinal plants ; Medicine ; Mucosa ; okra ; Oxidants ; Plant Components, Aerial ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Quercetin ; Rats ; Rats, Wistar ; Rodents ; Sodium ; Stomach Ulcer - chemically induced ; Stomach Ulcer - drug therapy ; Stomach Ulcer - pathology ; stomach ulcers ; Studies ; therapeutics ; Toxicity ; traditional medicine ; Treatment Outcome ; ulcer index ; ulcer inhibition ; Ulcers ; Vitamin A ; β-Carotene</subject><ispartof>Pharmaceutical biology, 2018-01, Vol.56 (1), p.165-175</ispartof><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2018</rights><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This work is licensed under the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2018 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c595t-fb181bf61236ad3364beb6409e46b7e2887c4a76a30276d60f4c2764846b22163</citedby><cites>FETCH-LOGICAL-c595t-fb181bf61236ad3364beb6409e46b7e2887c4a76a30276d60f4c2764846b22163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130549/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6130549/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,2096,27479,27901,27902,53766,53768,59116,59117</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29513129$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortaç, Deniz</creatorcontrib><creatorcontrib>Cemek, Mustafa</creatorcontrib><creatorcontrib>Karaca, Turan</creatorcontrib><creatorcontrib>Büyükokuroğlu, Mehmet E.</creatorcontrib><creatorcontrib>Özdemir, Zafer Ö.</creatorcontrib><creatorcontrib>Kocaman, Ayşe Tuba</creatorcontrib><creatorcontrib>Göneş, Sadık</creatorcontrib><title>In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions</title><title>Pharmaceutical biology</title><addtitle>Pharm Biol</addtitle><description>Context: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis.
Objective: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models.
Materials and methods: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que). Following a 60 min period, all the rats were given 1 mL of ethanol (80%). One hour after the administration of ethanol, all groups were sacrificed.
Results: At 5000 mg/kg, the extract produced (okra) no signs of toxicity in animals. Okra 500, 250, 100, Fam 20 and Que 75 inhibited ulcer formation by 81.0, 67.5, 67.0, 76.3 and 72.4%, respectively. Okra 500 significantly decreased edema, hemorrhage and inflammation scores compared with the ethanol group (p < 0.05). The oxidant levels decreased significantly in the all study groups compared within ethanol group (p < 0.001). Serum β-carotene and retinol levels significantly increased 40.2 and 45.4% in the okra 500 group. In okra 500, 250 and Fam 20 groups, apoptosis significantly decreased (p < 0.001), while okra 500, 250 and Fam 20 groups showed a higher percentage of cell proliferation compared with the ethanol group (p < 0.001).
Discussion and conclusions: Our in vivo data indicate that okra has a gastroprotective effect against ethanol and could reduce the gastric ulcer as seen from biochemical and histopathological results. We suggest that okra could be a possible therapeutic antiulcer agent.</description><subject>Abelmoschus</subject><subject>Abelmoschus esculentus</subject><subject>Animal models</subject><subject>Animals</subject><subject>anti-ulcer activity</subject><subject>Anti-Ulcer Agents - isolation & purification</subject><subject>Anti-Ulcer Agents - pharmacology</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Apoptosis</subject><subject>beta-carotene</subject><subject>Biochemistry</subject><subject>Bioengineering</subject><subject>blood serum</subject><subject>Cell growth</subject><subject>Cell proliferation</subject><subject>Edema</subject><subject>Ethanol</subject><subject>Ethanol - toxicity</subject><subject>Famotidine</subject><subject>Gastric Mucosa - drug effects</subject><subject>Gastric Mucosa - pathology</subject><subject>gastric ulcer</subject><subject>Gastritis</subject><subject>Gastroprotection</subject><subject>Hemorrhage</subject><subject>Herbal medicine</subject><subject>histopathology</subject><subject>immunohistochemistry</subject><subject>inflammation</subject><subject>laboratory animals</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicinal plants</subject><subject>Medicine</subject><subject>Mucosa</subject><subject>okra</subject><subject>Oxidants</subject><subject>Plant Components, Aerial</subject><subject>Plant Extracts - isolation & purification</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant Extracts - therapeutic use</subject><subject>Quercetin</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Sodium</subject><subject>Stomach Ulcer - chemically induced</subject><subject>Stomach Ulcer - drug therapy</subject><subject>Stomach Ulcer - pathology</subject><subject>stomach ulcers</subject><subject>Studies</subject><subject>therapeutics</subject><subject>Toxicity</subject><subject>traditional medicine</subject><subject>Treatment Outcome</subject><subject>ulcer index</subject><subject>ulcer inhibition</subject><subject>Ulcers</subject><subject>Vitamin A</subject><subject>β-Carotene</subject><issn>1388-0209</issn><issn>1744-5116</issn><issn>1744-5116</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>DOA</sourceid><recordid>eNp9kk1vEzEQhlcIREvgJ4AscSmHDf5a7-4FUVV8RKrEBc7WrHecODh2a-8G9d_jkLSiHDh55Hn82GO9VfWa0SWjHX3PRNdRTvslp6xbMim57NiT6py1UtYNY-ppqQtTH6Cz6kXOW0ppI0TzvDrjfcME4_15dbsKZO_2kUCYXD17gymuMThD0Fo0E4mWxJ8JyMXlgH4Xs9nMmWA2s8cwzfkdiYHgtIEQfe3COBscCZh5QrKGPKUi2s0mZvDEY3Yx5JfVMws-46vTuqh-fP70_eprff3ty-rq8ro2Td9MtR1YxwarGBcKRiGUHHBQkvYo1dAi77rWSGgVCMpbNSpqpSmF7Eqbc6bEolodvWOErb5JbgfpTkdw-s9GTGsNaXLGo-77rkUJrB0GkH0PwC1vJTYcDDWstcX14ei6mYcdjqaMnsA_kj7uBLfR67jXignayL4ILk6CFG9nzJPeuWzQewgY56y5FL3kghV-Ub39B93GOYXyVZqLhlHJJOWFao6USTHnhPbhMYzqQ0D0fUD0ISD6FJBy7s3fkzycuk9EAT4eARdsTDv4FZMf9QR3PiabIBiXtfj_Hb8BYMfKmg</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Ortaç, Deniz</creator><creator>Cemek, Mustafa</creator><creator>Karaca, Turan</creator><creator>Büyükokuroğlu, Mehmet E.</creator><creator>Özdemir, Zafer Ö.</creator><creator>Kocaman, Ayşe Tuba</creator><creator>Göneş, Sadık</creator><general>Taylor & Francis</general><general>Taylor & Francis Ltd</general><general>Taylor & Francis Group</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20180101</creationdate><title>In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions</title><author>Ortaç, Deniz ; Cemek, Mustafa ; Karaca, Turan ; Büyükokuroğlu, Mehmet E. ; Özdemir, Zafer Ö. ; Kocaman, Ayşe Tuba ; Göneş, Sadık</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c595t-fb181bf61236ad3364beb6409e46b7e2887c4a76a30276d60f4c2764846b22163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Abelmoschus</topic><topic>Abelmoschus esculentus</topic><topic>Animal models</topic><topic>Animals</topic><topic>anti-ulcer activity</topic><topic>Anti-Ulcer Agents - isolation & purification</topic><topic>Anti-Ulcer Agents - pharmacology</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Apoptosis</topic><topic>beta-carotene</topic><topic>Biochemistry</topic><topic>Bioengineering</topic><topic>blood serum</topic><topic>Cell growth</topic><topic>Cell proliferation</topic><topic>Edema</topic><topic>Ethanol</topic><topic>Ethanol - toxicity</topic><topic>Famotidine</topic><topic>Gastric Mucosa - drug effects</topic><topic>Gastric Mucosa - pathology</topic><topic>gastric ulcer</topic><topic>Gastritis</topic><topic>Gastroprotection</topic><topic>Hemorrhage</topic><topic>Herbal medicine</topic><topic>histopathology</topic><topic>immunohistochemistry</topic><topic>inflammation</topic><topic>laboratory animals</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicinal plants</topic><topic>Medicine</topic><topic>Mucosa</topic><topic>okra</topic><topic>Oxidants</topic><topic>Plant Components, Aerial</topic><topic>Plant Extracts - isolation & purification</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant Extracts - therapeutic use</topic><topic>Quercetin</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Sodium</topic><topic>Stomach Ulcer - chemically induced</topic><topic>Stomach Ulcer - drug therapy</topic><topic>Stomach Ulcer - pathology</topic><topic>stomach ulcers</topic><topic>Studies</topic><topic>therapeutics</topic><topic>Toxicity</topic><topic>traditional medicine</topic><topic>Treatment Outcome</topic><topic>ulcer index</topic><topic>ulcer inhibition</topic><topic>Ulcers</topic><topic>Vitamin A</topic><topic>β-Carotene</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortaç, Deniz</creatorcontrib><creatorcontrib>Cemek, Mustafa</creatorcontrib><creatorcontrib>Karaca, Turan</creatorcontrib><creatorcontrib>Büyükokuroğlu, Mehmet E.</creatorcontrib><creatorcontrib>Özdemir, Zafer Ö.</creatorcontrib><creatorcontrib>Kocaman, Ayşe Tuba</creatorcontrib><creatorcontrib>Göneş, Sadık</creatorcontrib><collection>Taylor & Francis Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Pharmaceutical biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortaç, Deniz</au><au>Cemek, Mustafa</au><au>Karaca, Turan</au><au>Büyükokuroğlu, Mehmet E.</au><au>Özdemir, Zafer Ö.</au><au>Kocaman, Ayşe Tuba</au><au>Göneş, Sadık</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions</atitle><jtitle>Pharmaceutical biology</jtitle><addtitle>Pharm Biol</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>56</volume><issue>1</issue><spage>165</spage><epage>175</epage><pages>165-175</pages><issn>1388-0209</issn><issn>1744-5116</issn><eissn>1744-5116</eissn><abstract>Context: Okra, Abelmoschus esculentus (L.) (Malvaceae), is a medicinal plant widely used in Turkish traditional medicine for the treatment of various diseases such as ulcers and gastritis.
Objective: In the present study, we evaluated the gastroprotective effect of okra against ethanol-induced acute gastric mucosal injury in animal models.
Materials and methods: Wistar rats were treated with 500, 250 or 100 mg/kg okra; 20 mg/kg famotidine (Fam); and 75 mg/kg quercetin (Que). Following a 60 min period, all the rats were given 1 mL of ethanol (80%). One hour after the administration of ethanol, all groups were sacrificed.
Results: At 5000 mg/kg, the extract produced (okra) no signs of toxicity in animals. Okra 500, 250, 100, Fam 20 and Que 75 inhibited ulcer formation by 81.0, 67.5, 67.0, 76.3 and 72.4%, respectively. Okra 500 significantly decreased edema, hemorrhage and inflammation scores compared with the ethanol group (p < 0.05). The oxidant levels decreased significantly in the all study groups compared within ethanol group (p < 0.001). Serum β-carotene and retinol levels significantly increased 40.2 and 45.4% in the okra 500 group. In okra 500, 250 and Fam 20 groups, apoptosis significantly decreased (p < 0.001), while okra 500, 250 and Fam 20 groups showed a higher percentage of cell proliferation compared with the ethanol group (p < 0.001).
Discussion and conclusions: Our in vivo data indicate that okra has a gastroprotective effect against ethanol and could reduce the gastric ulcer as seen from biochemical and histopathological results. We suggest that okra could be a possible therapeutic antiulcer agent.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>29513129</pmid><doi>10.1080/13880209.2018.1442481</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1388-0209 |
| ispartof | Pharmaceutical biology, 2018-01, Vol.56 (1), p.165-175 |
| issn | 1388-0209 1744-5116 1744-5116 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2439423161 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Taylor & Francis Open Access Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Abelmoschus Abelmoschus esculentus Animal models Animals anti-ulcer activity Anti-Ulcer Agents - isolation & purification Anti-Ulcer Agents - pharmacology Anti-Ulcer Agents - therapeutic use Apoptosis beta-carotene Biochemistry Bioengineering blood serum Cell growth Cell proliferation Edema Ethanol Ethanol - toxicity Famotidine Gastric Mucosa - drug effects Gastric Mucosa - pathology gastric ulcer Gastritis Gastroprotection Hemorrhage Herbal medicine histopathology immunohistochemistry inflammation laboratory animals Male Medical research Medicinal plants Medicine Mucosa okra Oxidants Plant Components, Aerial Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Quercetin Rats Rats, Wistar Rodents Sodium Stomach Ulcer - chemically induced Stomach Ulcer - drug therapy Stomach Ulcer - pathology stomach ulcers Studies therapeutics Toxicity traditional medicine Treatment Outcome ulcer index ulcer inhibition Ulcers Vitamin A β-Carotene |
| title | In vivo anti-ulcerogenic effect of okra (Abelmoschus esculentus) on ethanol-induced acute gastric mucosal lesions |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T00%3A43%3A31IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_infor&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=In%20vivo%20anti-ulcerogenic%20effect%20of%20okra%20(Abelmoschus%20esculentus)%20on%20ethanol-induced%20acute%20gastric%20mucosal%20lesions&rft.jtitle=Pharmaceutical%20biology&rft.au=Orta%C3%A7,%20Deniz&rft.date=2018-01-01&rft.volume=56&rft.issue=1&rft.spage=165&rft.epage=175&rft.pages=165-175&rft.issn=1388-0209&rft.eissn=1744-5116&rft_id=info:doi/10.1080/13880209.2018.1442481&rft_dat=%3Cproquest_infor%3E2439423161%3C/proquest_infor%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2351041402&rft_id=info:pmid/29513129&rft_doaj_id=oai_doaj_org_article_9987e4a17bba499aa2f274e52ac0c17f&rfr_iscdi=true |