Huai hua san alleviates dextran sulphate sodium-induced colitis and modulates colonic microbiota

Huai hua san (HHS) is a traditional Chinese herbal formula which is firstly documented in the ancient Chinese classic medical work “Pu Ji Ben Shi Fang” in 1132 AD. It has been widely used in the treatment of lower gastrointestinal disorders such as acute colitis and hematochezia for more than 800 ye...

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Veröffentlicht in:	Journal of ethnopharmacology 2020-09, Vol.259, p.112944, Article 112944
Hauptverfasser:	Liu, Ping, Bian, Yifei, Liu, Tianlong, Zhong, Jia, Zhong, Yuan, Zhuang, Shen, Liu, Zhongjie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Inflammatory Agents - pharmacology Bacteria - classification Bacteria - drug effects Bacteria - growth & development Bacteroidetes Carrier Proteins - metabolism Colitis - chemically induced Colitis - drug therapy Colitis - metabolism Colitis - microbiology Colon - drug effects Colon - metabolism Colon - microbiology Colon - ultrastructure Colonic microbiota dextran Dextran Sulfate Disease Models, Animal Drugs, Chinese Herbal - pharmacology Dysbiosis enzyme-linked immunosorbent assay Firmicutes gastrointestinal diseases Gastrointestinal Microbiome - drug effects genes Gut microbial dysbiosis Gut-vascular barrier Huai hua san inflammation Inflammation Mediators - metabolism intestinal microorganisms Male microbial communities oral administration Permeability protein content rats Rats, Sprague-Dawley ribosomal RNA sequence analysis signs and symptoms (animals and humans) sulfates traditional medicine tumor necrosis factor-alpha Tumor Necrosis Factor-alpha - metabolism Ulcerative colitis
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