Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study
Background and Objectives Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appear...
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| Veröffentlicht in: | Lasers in surgery and medicine 2021-04, Vol.53 (4), p.482-487 |
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| creator | Fawzi, Marwa M.T. Gawdat, Heba I. Mahmoud, Sara B. El‐Hawary, Marwa S. Rashed, Laila A. Esmat, Samia M. |
| description | Background and Objectives
Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appearance, histological pattern, and pruritus. The aim of this study is to assess the effect of fractional CO2 laser on pruritus associated with PCA, and analyze whether this effect is related to IL‐31 and IL‐31 receptor (R) expression.
Study Design/Materials and Methods
The study included 24 patients with PCA and 24 healthy controls. Each patient received four fractional CO2 laser sessions, 4 weeks apart, using the superficial ablative mode. Skin biopsies were taken from patients before and after treatment, as well as controls, for assessment of IL‐31 and IL‐31R by real‐time polymerase chain reaction.
Results
Treatment resulted in significant improvement of all clinical parameters, including pruritus (P |
| doi_str_mv | 10.1002/lsm.23313 |
| format | Article |
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Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appearance, histological pattern, and pruritus. The aim of this study is to assess the effect of fractional CO2 laser on pruritus associated with PCA, and analyze whether this effect is related to IL‐31 and IL‐31 receptor (R) expression.
Study Design/Materials and Methods
The study included 24 patients with PCA and 24 healthy controls. Each patient received four fractional CO2 laser sessions, 4 weeks apart, using the superficial ablative mode. Skin biopsies were taken from patients before and after treatment, as well as controls, for assessment of IL‐31 and IL‐31R by real‐time polymerase chain reaction.
Results
Treatment resulted in significant improvement of all clinical parameters, including pruritus (P < 0.001). Patients before treatment had significantly higher IL‐31 and IL‐31R than controls (P = 0.000 for both). In addition, there was a statistically significant decrease in IL‐31 and IL‐31R after treatment than their values before treatment (P = 0.000 for both).
Conclusion
This study confirms the therapeutic efficacy of fractional CO2 laser in treatment of PCA. Reduction of IL‐31 and its receptor seems to be one of the involved mechanisms; however, its relation to improvement of pruritus is still not clear. Lasers Surg. Med. © 2020 Wiley Periodicals LLC</description><identifier>ISSN: 0196-8092</identifier><identifier>EISSN: 1096-9101</identifier><identifier>DOI: 10.1002/lsm.23313</identifier><identifier>PMID: 32865828</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Ablation ; Amyloidosis ; Amyloidosis, Familial ; Carbon dioxide ; Carbon dioxide lasers ; Cytokines ; fractional carbon dioxide laser ; Health services ; Humans ; IL‐31 receptor ; Interleukins ; interleukin‐31 ; Lasers ; Lasers, Gas - therapeutic use ; Patients ; Polymerase chain reaction ; primary cutaneous amyloidosis ; Pruritus ; Pruritus - etiology ; Receptors ; Skin Diseases, Genetic ; Statistical analysis ; Treatment Outcome</subject><ispartof>Lasers in surgery and medicine, 2021-04, Vol.53 (4), p.482-487</ispartof><rights>2020 Wiley Periodicals LLC</rights><rights>2020 Wiley Periodicals LLC.</rights><rights>2021 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4193-95ebbe5ddf23b5152f60ff7adba1f42fa8138d0022c8275212c758a1aac57bfa3</citedby><cites>FETCH-LOGICAL-c4193-95ebbe5ddf23b5152f60ff7adba1f42fa8138d0022c8275212c758a1aac57bfa3</cites><orcidid>0000-0002-4326-4319</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Flsm.23313$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Flsm.23313$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45552,45553</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32865828$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fawzi, Marwa M.T.</creatorcontrib><creatorcontrib>Gawdat, Heba I.</creatorcontrib><creatorcontrib>Mahmoud, Sara B.</creatorcontrib><creatorcontrib>El‐Hawary, Marwa S.</creatorcontrib><creatorcontrib>Rashed, Laila A.</creatorcontrib><creatorcontrib>Esmat, Samia M.</creatorcontrib><title>Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study</title><title>Lasers in surgery and medicine</title><addtitle>Lasers Surg Med</addtitle><description>Background and Objectives
Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appearance, histological pattern, and pruritus. The aim of this study is to assess the effect of fractional CO2 laser on pruritus associated with PCA, and analyze whether this effect is related to IL‐31 and IL‐31 receptor (R) expression.
Study Design/Materials and Methods
The study included 24 patients with PCA and 24 healthy controls. Each patient received four fractional CO2 laser sessions, 4 weeks apart, using the superficial ablative mode. Skin biopsies were taken from patients before and after treatment, as well as controls, for assessment of IL‐31 and IL‐31R by real‐time polymerase chain reaction.
Results
Treatment resulted in significant improvement of all clinical parameters, including pruritus (P < 0.001). Patients before treatment had significantly higher IL‐31 and IL‐31R than controls (P = 0.000 for both). In addition, there was a statistically significant decrease in IL‐31 and IL‐31R after treatment than their values before treatment (P = 0.000 for both).
Conclusion
This study confirms the therapeutic efficacy of fractional CO2 laser in treatment of PCA. Reduction of IL‐31 and its receptor seems to be one of the involved mechanisms; however, its relation to improvement of pruritus is still not clear. Lasers Surg. Med. © 2020 Wiley Periodicals LLC</description><subject>Ablation</subject><subject>Amyloidosis</subject><subject>Amyloidosis, Familial</subject><subject>Carbon dioxide</subject><subject>Carbon dioxide lasers</subject><subject>Cytokines</subject><subject>fractional carbon dioxide laser</subject><subject>Health services</subject><subject>Humans</subject><subject>IL‐31 receptor</subject><subject>Interleukins</subject><subject>interleukin‐31</subject><subject>Lasers</subject><subject>Lasers, Gas - therapeutic use</subject><subject>Patients</subject><subject>Polymerase chain reaction</subject><subject>primary cutaneous amyloidosis</subject><subject>Pruritus</subject><subject>Pruritus - etiology</subject><subject>Receptors</subject><subject>Skin Diseases, Genetic</subject><subject>Statistical analysis</subject><subject>Treatment Outcome</subject><issn>0196-8092</issn><issn>1096-9101</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kctKxDAUhoMoOl4WvoAE3OhiNJdJm7obq6PCiIK6LmkuGEkbTVp1nsGXNmPVheDq5Jx8-U_4fwB2MTrCCJFjF5sjQimmK2CEUZGNC4zwKhghnM4cFWQDbMb4hBCiBOXrYIMSnjFO-Ah8zIKQnfWtcLAUofYtPLP-3SoN5yLqAG2E58boxLxqaFs4bbSzPojlG-gNvA19sF0fl3e3wTYiLGDZd6LVPg2nzcJ5q3y08QROYelsa2VaJVoFT62Xj7r56u-6Xi22wZoRLuqd77oFHmbn9-XleH5zcVVO52M5wQUdF0zXtWZKGUJrhhkxGTImF6oW2EyIERxTrpIvRHKSM4KJzBkXWAjJ8toIugUOBt3n4F96HbuqsVFq54ZPV2RCeVFQzFFC9_-gT74PyaxEMUyyLJ_QIlGHAyWDjzFoUz0PTlQYVcuEqpRQ9ZVQYve-Ffu60eqX_IkkAccD8GadXvyvVM3vrgfJT0Prm5E</recordid><startdate>202104</startdate><enddate>202104</enddate><creator>Fawzi, Marwa M.T.</creator><creator>Gawdat, Heba I.</creator><creator>Mahmoud, Sara B.</creator><creator>El‐Hawary, Marwa S.</creator><creator>Rashed, Laila A.</creator><creator>Esmat, Samia M.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>M7Z</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-4326-4319</orcidid></search><sort><creationdate>202104</creationdate><title>Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study</title><author>Fawzi, Marwa M.T. ; Gawdat, Heba I. ; Mahmoud, Sara B. ; El‐Hawary, Marwa S. ; Rashed, Laila A. ; Esmat, Samia M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4193-95ebbe5ddf23b5152f60ff7adba1f42fa8138d0022c8275212c758a1aac57bfa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Ablation</topic><topic>Amyloidosis</topic><topic>Amyloidosis, Familial</topic><topic>Carbon dioxide</topic><topic>Carbon dioxide lasers</topic><topic>Cytokines</topic><topic>fractional carbon dioxide laser</topic><topic>Health services</topic><topic>Humans</topic><topic>IL‐31 receptor</topic><topic>Interleukins</topic><topic>interleukin‐31</topic><topic>Lasers</topic><topic>Lasers, Gas - therapeutic use</topic><topic>Patients</topic><topic>Polymerase chain reaction</topic><topic>primary cutaneous amyloidosis</topic><topic>Pruritus</topic><topic>Pruritus - etiology</topic><topic>Receptors</topic><topic>Skin Diseases, Genetic</topic><topic>Statistical analysis</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fawzi, Marwa M.T.</creatorcontrib><creatorcontrib>Gawdat, Heba I.</creatorcontrib><creatorcontrib>Mahmoud, Sara B.</creatorcontrib><creatorcontrib>El‐Hawary, Marwa S.</creatorcontrib><creatorcontrib>Rashed, Laila A.</creatorcontrib><creatorcontrib>Esmat, Samia M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biochemistry Abstracts 1</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Lasers in surgery and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fawzi, Marwa M.T.</au><au>Gawdat, Heba I.</au><au>Mahmoud, Sara B.</au><au>El‐Hawary, Marwa S.</au><au>Rashed, Laila A.</au><au>Esmat, Samia M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study</atitle><jtitle>Lasers in surgery and medicine</jtitle><addtitle>Lasers Surg Med</addtitle><date>2021-04</date><risdate>2021</risdate><volume>53</volume><issue>4</issue><spage>482</spage><epage>487</epage><pages>482-487</pages><issn>0196-8092</issn><eissn>1096-9101</eissn><abstract>Background and Objectives
Primary cutaneous amyloidosis (PCA) is a pruritic disease characterized by amyloid deposition in the skin. Interleukin‐31 (IL‐31) is a pruritus‐mediating cytokine. Fractional carbon dioxide (CO2) laser has shown efficacy in the treatment of PCA regarding the clinical appearance, histological pattern, and pruritus. The aim of this study is to assess the effect of fractional CO2 laser on pruritus associated with PCA, and analyze whether this effect is related to IL‐31 and IL‐31 receptor (R) expression.
Study Design/Materials and Methods
The study included 24 patients with PCA and 24 healthy controls. Each patient received four fractional CO2 laser sessions, 4 weeks apart, using the superficial ablative mode. Skin biopsies were taken from patients before and after treatment, as well as controls, for assessment of IL‐31 and IL‐31R by real‐time polymerase chain reaction.
Results
Treatment resulted in significant improvement of all clinical parameters, including pruritus (P < 0.001). Patients before treatment had significantly higher IL‐31 and IL‐31R than controls (P = 0.000 for both). In addition, there was a statistically significant decrease in IL‐31 and IL‐31R after treatment than their values before treatment (P = 0.000 for both).
Conclusion
This study confirms the therapeutic efficacy of fractional CO2 laser in treatment of PCA. Reduction of IL‐31 and its receptor seems to be one of the involved mechanisms; however, its relation to improvement of pruritus is still not clear. Lasers Surg. Med. © 2020 Wiley Periodicals LLC</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>32865828</pmid><doi>10.1002/lsm.23313</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0002-4326-4319</orcidid></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Ablation Amyloidosis Amyloidosis, Familial Carbon dioxide Carbon dioxide lasers Cytokines fractional carbon dioxide laser Health services Humans IL‐31 receptor Interleukins interleukin‐31 Lasers Lasers, Gas - therapeutic use Patients Polymerase chain reaction primary cutaneous amyloidosis Pruritus Pruritus - etiology Receptors Skin Diseases, Genetic Statistical analysis Treatment Outcome |
| title | Fractional Carbon Dioxide Laser is Effective in Amelioration of Pruritus in Primary Cutaneous Amyloidosis: A Clinical and Biochemical Study |
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