Specific cellular internalization and pH-responsive behavior of doxorubicin loaded PLGA-PEG nanoparticles targeted with anti EGFRvIII antibody

Antibody-conjugated nanoparticles have attracted much attention in the field of cancer treatment due to the enhancement of the tumor cell response to anticancer drugs as well as reducing the side effects of chemotherapeutic agents on healthy tissues. However, most studies in this field generally men...

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Veröffentlicht in:	Life sciences (1973) 2020-11, Vol.261, p.118361-118361, Article 118361
Hauptverfasser:	Eivazi, Neda, Rahmani, Reza, Paknejad, Maliheh
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino groups Annexin V Antibodies Antineoplastic drugs Antitumor agents Apoptosis Assaying Biocompatibility Cell cycle Chemotherapy Cytotoxicity Doxorubicin Drug delivery Drug delivery systems EGFRvIII Entrapment Glycolic acid Internalization Monoclonal antibodies Monoclonal antibody Nanoparticles pH effects pH responsive PLGA-PEG-COOH Polyethylene glycol Polyimide resins Polylactide-co-glycolide Polyvinyl alcohol Selectivity Sensitivity Side effects Toxicity Transmission electron microscopy
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