Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis
In the present work we have focused on the Histone Deacetylase (HDAC) control of myeloid cells behavior during Xenopus tail regeneration. Here we show that myeloid differentiation is crucial to modulate the regenerative ability of Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity...
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| Veröffentlicht in: | Developmental and comparative immunology 2021-01, Vol.114, p.103840-103840, Article 103840 |
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| container_title | Developmental and comparative immunology |
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| creator | Pentagna, Nathalia Pinheiro da Costa, Thayse Soares dos Santos Cardoso, Fellipe Martins de Almeida, Fernanda Blanco Martinez, Ana Maria Abreu, José Garcia Levin, Michael Carneiro, Katia |
| description | In the present work we have focused on the Histone Deacetylase (HDAC) control of myeloid cells behavior during Xenopus tail regeneration. Here we show that myeloid differentiation is crucial to modulate the regenerative ability of Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity inhibition during the first wave of myeloid differentiation disrupted myeloid cells dynamics in the regenerative bud as well the mRNA expression pattern of myeloid markers, such as LURP, MPOX, Spib and mmp7. We also functionally bridge the spatial and temporal dynamics of lipid droplets, the main platform of lipid mediators synthesis in myeloid cells during the inflammatory response, and the regenerative ability of Xenopus tadpoles. In addition, we showed that 15-LOX activity is necessary during tail regeneration. Taken together our results support a role for the epigenetic control of myeloid behavior during tissue and organ regeneration, which may positively impact translational approaches for regenerative medicine.
•Myeloid cells modulate the regenerative ability of Xenopustadpoles in a HDAC activity-dependent fashion.•HDAC activity inhibition during the first wave of myeloid differentiation disrupted Xenopustail regeneration.•Myeloid gene expression pattern depends on HDAC activity.•15-lipoxigenase (15-LOX) activity is necessary for Xenopus tail regeneration. |
| doi_str_mv | 10.1016/j.dci.2020.103840 |
| format | Article |
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•Myeloid cells modulate the regenerative ability of Xenopustadpoles in a HDAC activity-dependent fashion.•HDAC activity inhibition during the first wave of myeloid differentiation disrupted Xenopustail regeneration.•Myeloid gene expression pattern depends on HDAC activity.•15-lipoxigenase (15-LOX) activity is necessary for Xenopus tail regeneration.</description><identifier>ISSN: 0145-305X</identifier><identifier>EISSN: 1879-0089</identifier><identifier>DOI: 10.1016/j.dci.2020.103840</identifier><identifier>PMID: 32858087</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Biomarkers - metabolism ; Cell Differentiation ; Cells, Cultured ; Differentiation ; Epigenesis, Genetic ; Epigenetics ; Gene expression ; Gene Expression Regulation, Developmental ; Histone deacetylase ; Histone Deacetylases - metabolism ; Histones ; Humans ; Inflammation ; Inflammatory response ; Juveniles ; Lipids ; Liquid oxygen ; Matrilysin ; Myeloid cells ; Myeloid Cells - metabolism ; Organogenesis ; Regeneration ; Regeneration (physiology) ; Regenerative Medicine ; Tissue and organ regeneration ; Tissue engineering ; Xenopus ; Xenopus laevis - physiology ; Xenopus laevis tail</subject><ispartof>Developmental and comparative immunology, 2021-01, Vol.114, p.103840-103840, Article 103840</ispartof><rights>2020 Elsevier Ltd</rights><rights>Copyright © 2020 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Science Ltd. Jan 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c381t-80e3f81b02dbbf69915cb3e9b20dcc8568a3ba9f3df81286e3b84f460f6daf393</citedby><cites>FETCH-LOGICAL-c381t-80e3f81b02dbbf69915cb3e9b20dcc8568a3ba9f3df81286e3b84f460f6daf393</cites><orcidid>0000-0002-9392-4039 ; 0000-0001-5901-208X ; 0000-0002-0821-5730</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0145305X20303955$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32858087$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pentagna, Nathalia</creatorcontrib><creatorcontrib>Pinheiro da Costa, Thayse</creatorcontrib><creatorcontrib>Soares dos Santos Cardoso, Fellipe</creatorcontrib><creatorcontrib>Martins de Almeida, Fernanda</creatorcontrib><creatorcontrib>Blanco Martinez, Ana Maria</creatorcontrib><creatorcontrib>Abreu, José Garcia</creatorcontrib><creatorcontrib>Levin, Michael</creatorcontrib><creatorcontrib>Carneiro, Katia</creatorcontrib><title>Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis</title><title>Developmental and comparative immunology</title><addtitle>Dev Comp Immunol</addtitle><description>In the present work we have focused on the Histone Deacetylase (HDAC) control of myeloid cells behavior during Xenopus tail regeneration. Here we show that myeloid differentiation is crucial to modulate the regenerative ability of Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity inhibition during the first wave of myeloid differentiation disrupted myeloid cells dynamics in the regenerative bud as well the mRNA expression pattern of myeloid markers, such as LURP, MPOX, Spib and mmp7. We also functionally bridge the spatial and temporal dynamics of lipid droplets, the main platform of lipid mediators synthesis in myeloid cells during the inflammatory response, and the regenerative ability of Xenopus tadpoles. In addition, we showed that 15-LOX activity is necessary during tail regeneration. Taken together our results support a role for the epigenetic control of myeloid behavior during tissue and organ regeneration, which may positively impact translational approaches for regenerative medicine.
•Myeloid cells modulate the regenerative ability of Xenopustadpoles in a HDAC activity-dependent fashion.•HDAC activity inhibition during the first wave of myeloid differentiation disrupted Xenopustail regeneration.•Myeloid gene expression pattern depends on HDAC activity.•15-lipoxigenase (15-LOX) activity is necessary for Xenopus tail regeneration.</description><subject>Animals</subject><subject>Biomarkers - metabolism</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Differentiation</subject><subject>Epigenesis, Genetic</subject><subject>Epigenetics</subject><subject>Gene expression</subject><subject>Gene Expression Regulation, Developmental</subject><subject>Histone deacetylase</subject><subject>Histone Deacetylases - metabolism</subject><subject>Histones</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammatory response</subject><subject>Juveniles</subject><subject>Lipids</subject><subject>Liquid oxygen</subject><subject>Matrilysin</subject><subject>Myeloid cells</subject><subject>Myeloid Cells - metabolism</subject><subject>Organogenesis</subject><subject>Regeneration</subject><subject>Regeneration (physiology)</subject><subject>Regenerative Medicine</subject><subject>Tissue and organ regeneration</subject><subject>Tissue engineering</subject><subject>Xenopus</subject><subject>Xenopus laevis - physiology</subject><subject>Xenopus laevis tail</subject><issn>0145-305X</issn><issn>1879-0089</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1uGyEURlHVqnHTPkA3FVI36WIcGGbGoK4iJ40rRcqmlbJD_NxxscbgAmNpXiFPHUZOu8gibBC6535wOQh9pmRJCe0ud0tr3LIm9XxmvCFv0ILylagI4eItWhDatBUj7cMZ-pDSjpTFKXmPzljNW074aoEebw5uCx6yM9gEn2MYcOjxfoIhOIsNDEPCGv6oowsR6wlvXMrBA74GZSBPg0qAlcnu6PKELzbXV-tv2I7R-S3OLqWxVL3FIW6VxxHmq6LKLnjsPH4AHw5jwoOCo0sf0bteDQk-Pe_n6PePm1_rTXV3f_tzfXVXGcZprjgB1nOqSW217jshaGs0A6FrYo3hbccV00r0zBaq5h0wzZu-6UjfWdUzwc7RxSn3EMPfEVKWe5fmQZWHMCZZN4x3gjS0LejXF-gujNGX1xWqE5SLFVkVip4oE0NKEXp5iG6v4iQpkbMouZNFlJxFyZOo0vPlOXnUe7D_O_6ZKcD3EwDlK44OokzGgTdgXQSTpQ3ulfgn4JSktQ</recordid><startdate>202101</startdate><enddate>202101</enddate><creator>Pentagna, Nathalia</creator><creator>Pinheiro da Costa, Thayse</creator><creator>Soares dos Santos Cardoso, Fellipe</creator><creator>Martins de Almeida, Fernanda</creator><creator>Blanco Martinez, Ana Maria</creator><creator>Abreu, José Garcia</creator><creator>Levin, Michael</creator><creator>Carneiro, Katia</creator><general>Elsevier Ltd</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-9392-4039</orcidid><orcidid>https://orcid.org/0000-0001-5901-208X</orcidid><orcidid>https://orcid.org/0000-0002-0821-5730</orcidid></search><sort><creationdate>202101</creationdate><title>Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis</title><author>Pentagna, Nathalia ; Pinheiro da Costa, Thayse ; Soares dos Santos Cardoso, Fellipe ; Martins de Almeida, Fernanda ; Blanco Martinez, Ana Maria ; Abreu, José Garcia ; Levin, Michael ; Carneiro, Katia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c381t-80e3f81b02dbbf69915cb3e9b20dcc8568a3ba9f3df81286e3b84f460f6daf393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Biomarkers - metabolism</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Differentiation</topic><topic>Epigenesis, Genetic</topic><topic>Epigenetics</topic><topic>Gene expression</topic><topic>Gene Expression Regulation, Developmental</topic><topic>Histone deacetylase</topic><topic>Histone Deacetylases - metabolism</topic><topic>Histones</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammatory response</topic><topic>Juveniles</topic><topic>Lipids</topic><topic>Liquid oxygen</topic><topic>Matrilysin</topic><topic>Myeloid cells</topic><topic>Myeloid Cells - metabolism</topic><topic>Organogenesis</topic><topic>Regeneration</topic><topic>Regeneration (physiology)</topic><topic>Regenerative Medicine</topic><topic>Tissue and organ regeneration</topic><topic>Tissue engineering</topic><topic>Xenopus</topic><topic>Xenopus laevis - physiology</topic><topic>Xenopus laevis tail</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pentagna, Nathalia</creatorcontrib><creatorcontrib>Pinheiro da Costa, Thayse</creatorcontrib><creatorcontrib>Soares dos Santos Cardoso, Fellipe</creatorcontrib><creatorcontrib>Martins de Almeida, Fernanda</creatorcontrib><creatorcontrib>Blanco Martinez, Ana Maria</creatorcontrib><creatorcontrib>Abreu, José Garcia</creatorcontrib><creatorcontrib>Levin, Michael</creatorcontrib><creatorcontrib>Carneiro, Katia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Developmental and comparative immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pentagna, Nathalia</au><au>Pinheiro da Costa, Thayse</au><au>Soares dos Santos Cardoso, Fellipe</au><au>Martins de Almeida, Fernanda</au><au>Blanco Martinez, Ana Maria</au><au>Abreu, José Garcia</au><au>Levin, Michael</au><au>Carneiro, Katia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis</atitle><jtitle>Developmental and comparative immunology</jtitle><addtitle>Dev Comp Immunol</addtitle><date>2021-01</date><risdate>2021</risdate><volume>114</volume><spage>103840</spage><epage>103840</epage><pages>103840-103840</pages><artnum>103840</artnum><issn>0145-305X</issn><eissn>1879-0089</eissn><abstract>In the present work we have focused on the Histone Deacetylase (HDAC) control of myeloid cells behavior during Xenopus tail regeneration. Here we show that myeloid differentiation is crucial to modulate the regenerative ability of Xenopus tadpoles in a HDAC activity-dependent fashion. HDAC activity inhibition during the first wave of myeloid differentiation disrupted myeloid cells dynamics in the regenerative bud as well the mRNA expression pattern of myeloid markers, such as LURP, MPOX, Spib and mmp7. We also functionally bridge the spatial and temporal dynamics of lipid droplets, the main platform of lipid mediators synthesis in myeloid cells during the inflammatory response, and the regenerative ability of Xenopus tadpoles. In addition, we showed that 15-LOX activity is necessary during tail regeneration. Taken together our results support a role for the epigenetic control of myeloid behavior during tissue and organ regeneration, which may positively impact translational approaches for regenerative medicine.
•Myeloid cells modulate the regenerative ability of Xenopustadpoles in a HDAC activity-dependent fashion.•HDAC activity inhibition during the first wave of myeloid differentiation disrupted Xenopustail regeneration.•Myeloid gene expression pattern depends on HDAC activity.•15-lipoxigenase (15-LOX) activity is necessary for Xenopus tail regeneration.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>32858087</pmid><doi>10.1016/j.dci.2020.103840</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-9392-4039</orcidid><orcidid>https://orcid.org/0000-0001-5901-208X</orcidid><orcidid>https://orcid.org/0000-0002-0821-5730</orcidid></addata></record> |
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| subjects | Animals Biomarkers - metabolism Cell Differentiation Cells, Cultured Differentiation Epigenesis, Genetic Epigenetics Gene expression Gene Expression Regulation, Developmental Histone deacetylase Histone Deacetylases - metabolism Histones Humans Inflammation Inflammatory response Juveniles Lipids Liquid oxygen Matrilysin Myeloid cells Myeloid Cells - metabolism Organogenesis Regeneration Regeneration (physiology) Regenerative Medicine Tissue and organ regeneration Tissue engineering Xenopus Xenopus laevis - physiology Xenopus laevis tail |
| title | Epigenetic control of myeloid cells behavior by Histone Deacetylase activity (HDAC) during tissue and organ regeneration in Xenopus laevis |
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