Role of Rap1 in DNA damage response: implications in stem cell homeostasis and cancer

•Mammalian Rap1 protein acts as an adaptor in functional complexes formed under various physiological conditions.•Rap1 plays an important role in the DNA damage response at telomeric and nontelomeric regions, thus maintaining genome stability.•The role of Rap1 in the DNA damage response has implicat...

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Veröffentlicht in:	Experimental hematology 2020-10, Vol.90, p.12-17
Hauptverfasser:	Khattar, Ekta, Tergaonkar, Vinay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cellular Senescence DNA Damage Homeostasis Humans Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Neoplastic Stem Cells Signal Transduction Telomere - genetics Telomere - metabolism Telomere - pathology Telomere-Binding Proteins - genetics Telomere-Binding Proteins - metabolism
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