Deep learning algorithm for detection of aortic dissection on non-contrast-enhanced CT

Objectives To develop a deep learning–based algorithm to detect aortic dissection (AD) and evaluate the diagnostic ability of the algorithm compared with those of radiologists. Methods Included in the study were 170 patients (85 with AD and 85 without AD). An AD detection algorithm was developed usi...

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Veröffentlicht in:European radiology 2021-02, Vol.31 (2), p.1151-1159
Hauptverfasser: Hata, Akinori, Yanagawa, Masahiro, Yamagata, Kazuki, Suzuki, Yuuki, Kido, Shoji, Kawata, Atsushi, Doi, Shuhei, Yoshida, Yuriko, Miyata, Tomo, Tsubamoto, Mitsuko, Kikuchi, Noriko, Tomiyama, Noriyuki
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container_end_page 1159
container_issue 2
container_start_page 1151
container_title European radiology
container_volume 31
creator Hata, Akinori
Yanagawa, Masahiro
Yamagata, Kazuki
Suzuki, Yuuki
Kido, Shoji
Kawata, Atsushi
Doi, Shuhei
Yoshida, Yuriko
Miyata, Tomo
Tsubamoto, Mitsuko
Kikuchi, Noriko
Tomiyama, Noriyuki
description Objectives To develop a deep learning–based algorithm to detect aortic dissection (AD) and evaluate the diagnostic ability of the algorithm compared with those of radiologists. Methods Included in the study were 170 patients (85 with AD and 85 without AD). An AD detection algorithm was developed using a convolutional neural network with Xception architecture. Of the patient data, 80% were used for training and validation and 20% were used for testing. Fivefold cross-validation was performed to evaluate the method. An average of 6688 non-contrast-enhanced CT images (slice thickness, 5 mm) were used for training. A radiologist reviewed both contrast-enhanced and non-contrast-enhanced images and identified the slices of AD. The identified slices were used as ground truth. Receiver operating characteristic curve and area under the curve (AUC) analysis was performed. Five radiologists independently evaluated the images. The accuracy, sensitivity, and specificity of the algorithm and those of the radiologists were compared. Results The AUC of the developed algorithm was 0.940, and a cutoff value of 0.400 provided accuracy of 90.0%, sensitivity of 91.8%, and specificity of 88.2%. For the radiologists, median (range) accuracy, sensitivity, and specificity were 88.8 (83.5–94.1)%, 90.6 (83.5–94.1)%, and 94.1 (72.9–97.6)%, respectively. There was no significant difference in performance in terms of accuracy, sensitivity, or specificity between the algorithm and the average performance of the radiologists ( p > 0.05). Conclusions The developed algorithm showed comparable diagnostic performance to radiologists for detecting AD, which suggests the potential of the proposed method to support clinical practice by reducing missed ADs. Key Points • A deep learning–based algorithm for detecting aortic dissection was developed using the non-contrast-enhanced CT images of 170 patients. • The algorithm had an AUC of 0.940 for detecting aortic dissection. • The accuracy, sensitivity, and specificity of the algorithm were comparable to those of radiologists.
doi_str_mv 10.1007/s00330-020-07213-w
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Methods Included in the study were 170 patients (85 with AD and 85 without AD). An AD detection algorithm was developed using a convolutional neural network with Xception architecture. Of the patient data, 80% were used for training and validation and 20% were used for testing. Fivefold cross-validation was performed to evaluate the method. An average of 6688 non-contrast-enhanced CT images (slice thickness, 5 mm) were used for training. A radiologist reviewed both contrast-enhanced and non-contrast-enhanced images and identified the slices of AD. The identified slices were used as ground truth. Receiver operating characteristic curve and area under the curve (AUC) analysis was performed. Five radiologists independently evaluated the images. The accuracy, sensitivity, and specificity of the algorithm and those of the radiologists were compared. Results The AUC of the developed algorithm was 0.940, and a cutoff value of 0.400 provided accuracy of 90.0%, sensitivity of 91.8%, and specificity of 88.2%. For the radiologists, median (range) accuracy, sensitivity, and specificity were 88.8 (83.5–94.1)%, 90.6 (83.5–94.1)%, and 94.1 (72.9–97.6)%, respectively. There was no significant difference in performance in terms of accuracy, sensitivity, or specificity between the algorithm and the average performance of the radiologists ( p &gt; 0.05). Conclusions The developed algorithm showed comparable diagnostic performance to radiologists for detecting AD, which suggests the potential of the proposed method to support clinical practice by reducing missed ADs. Key Points • A deep learning–based algorithm for detecting aortic dissection was developed using the non-contrast-enhanced CT images of 170 patients. • The algorithm had an AUC of 0.940 for detecting aortic dissection. • The accuracy, sensitivity, and specificity of the algorithm were comparable to those of radiologists.</description><identifier>ISSN: 0938-7994</identifier><identifier>EISSN: 1432-1084</identifier><identifier>DOI: 10.1007/s00330-020-07213-w</identifier><identifier>PMID: 32857203</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Accuracy ; Algorithms ; Aneurysm, Dissecting - diagnostic imaging ; Aorta ; Aortic dissection ; Artificial intelligence ; Artificial neural networks ; Cardiac ; Computed tomography ; Deep Learning ; Diagnostic Radiology ; Diagnostic systems ; Dissection ; Ground truth ; Humans ; Image contrast ; Image enhancement ; Imaging ; Internal Medicine ; Interventional Radiology ; Machine learning ; Medical imaging ; Medicine ; Medicine &amp; Public Health ; Neural networks ; Neuroradiology ; Radiologists ; Radiology ; Tomography, X-Ray Computed ; Training ; Ultrasound</subject><ispartof>European radiology, 2021-02, Vol.31 (2), p.1151-1159</ispartof><rights>European Society of Radiology 2020</rights><rights>European Society of Radiology 2020.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c441t-65837dc359d04b1e4cb445a10a5da5e14ef606a60cb2e32ad3f46748d2aa7e843</citedby><cites>FETCH-LOGICAL-c441t-65837dc359d04b1e4cb445a10a5da5e14ef606a60cb2e32ad3f46748d2aa7e843</cites><orcidid>0000-0003-1149-7094</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00330-020-07213-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00330-020-07213-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32857203$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hata, Akinori</creatorcontrib><creatorcontrib>Yanagawa, Masahiro</creatorcontrib><creatorcontrib>Yamagata, Kazuki</creatorcontrib><creatorcontrib>Suzuki, Yuuki</creatorcontrib><creatorcontrib>Kido, Shoji</creatorcontrib><creatorcontrib>Kawata, Atsushi</creatorcontrib><creatorcontrib>Doi, Shuhei</creatorcontrib><creatorcontrib>Yoshida, Yuriko</creatorcontrib><creatorcontrib>Miyata, Tomo</creatorcontrib><creatorcontrib>Tsubamoto, Mitsuko</creatorcontrib><creatorcontrib>Kikuchi, Noriko</creatorcontrib><creatorcontrib>Tomiyama, Noriyuki</creatorcontrib><title>Deep learning algorithm for detection of aortic dissection on non-contrast-enhanced CT</title><title>European radiology</title><addtitle>Eur Radiol</addtitle><addtitle>Eur Radiol</addtitle><description>Objectives To develop a deep learning–based algorithm to detect aortic dissection (AD) and evaluate the diagnostic ability of the algorithm compared with those of radiologists. Methods Included in the study were 170 patients (85 with AD and 85 without AD). An AD detection algorithm was developed using a convolutional neural network with Xception architecture. Of the patient data, 80% were used for training and validation and 20% were used for testing. Fivefold cross-validation was performed to evaluate the method. An average of 6688 non-contrast-enhanced CT images (slice thickness, 5 mm) were used for training. A radiologist reviewed both contrast-enhanced and non-contrast-enhanced images and identified the slices of AD. The identified slices were used as ground truth. Receiver operating characteristic curve and area under the curve (AUC) analysis was performed. Five radiologists independently evaluated the images. The accuracy, sensitivity, and specificity of the algorithm and those of the radiologists were compared. 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Methods Included in the study were 170 patients (85 with AD and 85 without AD). An AD detection algorithm was developed using a convolutional neural network with Xception architecture. Of the patient data, 80% were used for training and validation and 20% were used for testing. Fivefold cross-validation was performed to evaluate the method. An average of 6688 non-contrast-enhanced CT images (slice thickness, 5 mm) were used for training. A radiologist reviewed both contrast-enhanced and non-contrast-enhanced images and identified the slices of AD. The identified slices were used as ground truth. Receiver operating characteristic curve and area under the curve (AUC) analysis was performed. Five radiologists independently evaluated the images. The accuracy, sensitivity, and specificity of the algorithm and those of the radiologists were compared. Results The AUC of the developed algorithm was 0.940, and a cutoff value of 0.400 provided accuracy of 90.0%, sensitivity of 91.8%, and specificity of 88.2%. For the radiologists, median (range) accuracy, sensitivity, and specificity were 88.8 (83.5–94.1)%, 90.6 (83.5–94.1)%, and 94.1 (72.9–97.6)%, respectively. There was no significant difference in performance in terms of accuracy, sensitivity, or specificity between the algorithm and the average performance of the radiologists ( p &gt; 0.05). Conclusions The developed algorithm showed comparable diagnostic performance to radiologists for detecting AD, which suggests the potential of the proposed method to support clinical practice by reducing missed ADs. Key Points • A deep learning–based algorithm for detecting aortic dissection was developed using the non-contrast-enhanced CT images of 170 patients. • The algorithm had an AUC of 0.940 for detecting aortic dissection. • The accuracy, sensitivity, and specificity of the algorithm were comparable to those of radiologists.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32857203</pmid><doi>10.1007/s00330-020-07213-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-1149-7094</orcidid></addata></record>
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source MEDLINE; SpringerLink Journals - AutoHoldings
subjects Accuracy
Algorithms
Aneurysm, Dissecting - diagnostic imaging
Aorta
Aortic dissection
Artificial intelligence
Artificial neural networks
Cardiac
Computed tomography
Deep Learning
Diagnostic Radiology
Diagnostic systems
Dissection
Ground truth
Humans
Image contrast
Image enhancement
Imaging
Internal Medicine
Interventional Radiology
Machine learning
Medical imaging
Medicine
Medicine & Public Health
Neural networks
Neuroradiology
Radiologists
Radiology
Tomography, X-Ray Computed
Training
Ultrasound
title Deep learning algorithm for detection of aortic dissection on non-contrast-enhanced CT
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