PDX1−/NKX6.1+ progenitors derived from human pluripotent stem cells as a novel source of insulin‐secreting cells

Aim Beta cell replacement strategies are a promising alternative for diabetes treatment. Human pluripotent stem cells (hPSCs) serve as a scalable source for producing insulin‐secreting cells for transplantation therapy. We recently generated novel hPSC‐derived pancreatic progenitors, expressing high...

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Veröffentlicht in:	Diabetes/metabolism research and reviews 2021-07, Vol.37 (5), p.e3400-n/a
Hauptverfasser:	Memon, Bushra, Younis, Ihab, Abubaker, Fadhil, Abdelalim, Essam M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Beta cells C-Peptide Cell differentiation Cell therapy Diabetes Diabetes Mellitus Glucose hESCs Homeodomain Proteins - genetics Humans Insulin insulin secretion Insulin-Secreting Cells Mesenchyme NESTIN Neural stem cells Nkx6.1 protein Pancreas transplantation Pancreatic islet transplantation Pluripotency Pluripotent Stem Cells Progenitor cells Stem cells Trans-Activators - genetics Transcriptomes
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