The presence of herpes simplex-1 and varicella zoster viruses is not related with clinical outcome of Bell's Palsy
Bell's Palsy is the most frequent acute neuropathy of cranial nerves; it has been associated in various reports to herpes viruses. In a prospective study we searched the presence of DNA from five herpes viruses (HSV-1 and 2, VZV, EBV and HHV-6) in 79 patients at the acute phase of Bell's P...
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| Veröffentlicht in: | Virology (New York, N.Y.) N.Y.), 2020-10, Vol.549, p.85-88 |
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| creator | Ordoñez, Graciela Vales, Olivia Pineda, Benjamín Rodríguez, Karla Pane, Carlo Sotelo, Julio |
| description | Bell's Palsy is the most frequent acute neuropathy of cranial nerves; it has been associated in various reports to herpes viruses. In a prospective study we searched the presence of DNA from five herpes viruses (HSV-1 and 2, VZV, EBV and HHV-6) in 79 patients at the acute phase of Bell's Palsy. Results were related with various parameters; age, gender and clinical outcome. We found the significant presence (p˂0.001) of HSV-1 and VZV in 39% and 42% of patients. However, a large percentage of cases were negative. When comparisons were made between subgroups according to gender and age no differences were found with viral findings nor with clinical outcome of palsy, which was of clinical remission in most cases (78%). Our results suggest that herpes viruses might participate in the complex mechanisms of autoimmunity of Bell's Palsy but not as determinant etiological element. |
| doi_str_mv | 10.1016/j.virol.2020.07.020 |
| format | Article |
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In a prospective study we searched the presence of DNA from five herpes viruses (HSV-1 and 2, VZV, EBV and HHV-6) in 79 patients at the acute phase of Bell's Palsy. Results were related with various parameters; age, gender and clinical outcome. We found the significant presence (p˂0.001) of HSV-1 and VZV in 39% and 42% of patients. However, a large percentage of cases were negative. When comparisons were made between subgroups according to gender and age no differences were found with viral findings nor with clinical outcome of palsy, which was of clinical remission in most cases (78%). Our results suggest that herpes viruses might participate in the complex mechanisms of autoimmunity of Bell's Palsy but not as determinant etiological element.</description><identifier>ISSN: 0042-6822</identifier><identifier>EISSN: 1096-0341</identifier><identifier>DOI: 10.1016/j.virol.2020.07.020</identifier><identifier>PMID: 32858308</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acyclovir ; Acyclovir - therapeutic use ; Adolescent ; Adrenal Cortex Hormones - therapeutic use ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Antibodies, Viral - blood ; Antiviral Agents - therapeutic use ; Autoimmunity ; Bell Palsy - drug therapy ; Bell Palsy - immunology ; Bell Palsy - pathology ; Bell Palsy - virology ; Bell's palsy ; Case-Control Studies ; DNA, Viral - blood ; DNA, Viral - genetics ; Facial nerve ; Facial Nerve - drug effects ; Facial Nerve - immunology ; Facial Nerve - pathology ; Facial Nerve - virology ; Female ; Herpes simplex virus ; Herpesvirus 1, Human - genetics ; Herpesvirus 1, Human - pathogenicity ; Herpesvirus 2, Human - genetics ; Herpesvirus 3, Human - genetics ; Herpesvirus 3, Human - pathogenicity ; Herpesvirus 4, Human - genetics ; Herpesvirus 6, Human - genetics ; Humans ; Immunoglobulin G - blood ; Male ; Middle Aged ; Prospective Studies ; Remission Induction ; Sex Factors ; Treatment Outcome ; Varicella zoster virus</subject><ispartof>Virology (New York, N.Y.), 2020-10, Vol.549, p.85-88</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. 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it has been associated in various reports to herpes viruses. In a prospective study we searched the presence of DNA from five herpes viruses (HSV-1 and 2, VZV, EBV and HHV-6) in 79 patients at the acute phase of Bell's Palsy. Results were related with various parameters; age, gender and clinical outcome. We found the significant presence (p˂0.001) of HSV-1 and VZV in 39% and 42% of patients. However, a large percentage of cases were negative. When comparisons were made between subgroups according to gender and age no differences were found with viral findings nor with clinical outcome of palsy, which was of clinical remission in most cases (78%). 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| subjects | Acyclovir Acyclovir - therapeutic use Adolescent Adrenal Cortex Hormones - therapeutic use Adult Age Factors Aged Aged, 80 and over Antibodies, Viral - blood Antiviral Agents - therapeutic use Autoimmunity Bell Palsy - drug therapy Bell Palsy - immunology Bell Palsy - pathology Bell Palsy - virology Bell's palsy Case-Control Studies DNA, Viral - blood DNA, Viral - genetics Facial nerve Facial Nerve - drug effects Facial Nerve - immunology Facial Nerve - pathology Facial Nerve - virology Female Herpes simplex virus Herpesvirus 1, Human - genetics Herpesvirus 1, Human - pathogenicity Herpesvirus 2, Human - genetics Herpesvirus 3, Human - genetics Herpesvirus 3, Human - pathogenicity Herpesvirus 4, Human - genetics Herpesvirus 6, Human - genetics Humans Immunoglobulin G - blood Male Middle Aged Prospective Studies Remission Induction Sex Factors Treatment Outcome Varicella zoster virus |
| title | The presence of herpes simplex-1 and varicella zoster viruses is not related with clinical outcome of Bell's Palsy |
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