Continuous Assembly of β-Roll Structures Is Implicated in the Type I-Dependent Secretion of Large Repeat-in-Toxins (RTX) Proteins

Repeats-in-Toxin (RTX) proteins of Gram-negative bacteria are excreted through the type I secretion system (T1SS) that recognizes non-cleavable C-terminal secretion signals. These are preceded by arrays of glycine and aspartate-rich nonapeptide repeats grouped by four to eight β strands into blocks...

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Veröffentlicht in:	Journal of molecular biology 2020-09, Vol.432 (20), p.5696-5710
Hauptverfasser:	Motlova, Lucia, Klimova, Nela, Fiser, Radovan, Sebo, Peter, Bumba, Ladislav
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin - chemistry Adenylate Cyclase Toxin - genetics Adenylate Cyclase Toxin - metabolism adenylate cyclase toxins Bacterial Proteins - chemistry Bacterial Proteins - metabolism Bacterial Toxins - chemistry Bacterial Toxins - genetics Bacterial Toxins - metabolism Bordetella pertussis Bordetella pertussis - metabolism Cytosol - metabolism Gram-Negative Bacteria - metabolism Protein Conformation Protein Folding RTX proteins type I secretion system Type I Secretion Systems
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