FoxO1 overexpression reduces Aβ production and tau phosphorylation in vitro

•FoxO1 reduces Aβ level by inhibiting the amyloid pathway mediated by BACE1 and PS1.•FoxO1 reduces tau phosphorylation by regulating the activities of GSK-3β and ERK.•FoxO1 plays a critical role in AD-like pathology and that FoxO1 is a novel target for AD treatment. Forkhead box O1 (FoxO1), a key mo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuroscience letters 2020-11, Vol.738, p.135322-135322, Article 135322
Hauptverfasser:	Zhang, Wei, Bai, Shanshan, Yang, Jianhua, Zhang, Yimin, Liu, Youcai, Nie, Junjiu, Meng, Dongli, Shi, Ruling, Yao, Zhaoyang, Wang, Mingyong, Wang, Hecheng, Li, Cuiping
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Animals BACE1 Forkhead Box Protein O1 - genetics Forkhead Box Protein O1 - metabolism FoxO1 GSK-3β HEK293 Cells Humans Mice Mice, Transgenic Phosphorylation Presenilin-1 - genetics Presenilin-1 - metabolism PS1 tau phosphorylation tau Proteins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!