Development and validation of a liquid chromatography coupled to tandem mass spectrometry method for the simultaneous quantification of five analgesics and sedatives, and six of their active metabolites in human plasma: Application to a clinical study on the determination of neurological death in the intensive care unit

•Extraction and analysis of drugs and metabolites using a single SPE extraction and single chromatographic condition.•Selective elution of propofol apart from the other ten analytes using a mixed-mode polymeric SPE sorbent.•Derivatization of propofol with permanently charged reagent FluMP increases...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2020-10, Vol.190, p.113521-113521, Article 113521
Hauptverfasser:	Jutras, Martin, Williamson, David, Chassé, Michaël, Leclair, Grégoire
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics Human plasma Liquid chromatography coupled to tandem mass spectrometry Method validation Neurological death Sedatives
Online-Zugang:	Volltext
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