Spironolactone ameliorates lipopolysaccharide-induced cholestasis in rats by improving Mrp2 function: Role of transcriptional and post-transcriptional mechanisms

Lipopolysaccharide (LPS) induces inflammatory cholestasis by impairing expression, localization, and function of carriers involved in bile formation, e.g. bile salt export pump (Bsep) and multidrug resistance-associated protein 2 (Mrp2). A specific therapy against this disease is still lacking. Ther...

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Veröffentlicht in:	Life sciences (1973) 2020-10, Vol.259, p.118352-118352, Article 118352
Hauptverfasser:	Razori, María Valeria, Martín, Pamela L., Maidagan, Paula M., Barosso, Ismael R., Ciriaci, Nadia, Andermatten, Romina B., Sánchez Pozzi, Enrique J., Basiglio, Cecilia L., Ruiz, María Laura, Roma, Marcelo G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-inflammatory agents Bile Cholestasis Confocal microscopy Gallbladder diseases Glutathione Glutathione transporter Hepatocellular transporters Homeostasis IL-1β Immunofluorescence Inflammation Interleukin 6 Internalization Lipopolysaccharide-induced cholestasis Lipopolysaccharides Localization Multidrug resistance Multidrug resistance-associated protein 2 Normalizing Plasma levels Post-transcription Proteins Recovery Salts Spironolactone Substrates Tumor necrosis factor-α
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