BILITE: A Bayesian randomized phase II design for immunotherapy by jointly modeling the longitudinal immune response and time‐to‐event efficacy

Immunotherapy—treatments that target a patient's immune system—has attracted considerable attention in cancer research. Its recent success has led to generation of novel immunotherapeutic agents that need to be evaluated in clinical trials. Two unique features of immunotherapy are the immune re...

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Veröffentlicht in:	Statistics in medicine 2020-12, Vol.39 (29), p.4439-4451
Hauptverfasser:	Guo, Beibei, Zang, Yong
Format:	Artikel
Sprache:	eng
Schlagworte:	Bayesian adaptive design cure models Immunotherapy longitudinal immune response
Online-Zugang:	Volltext
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