Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways
Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The effect of biochanin A (BCA) has been examined in ost...
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| Veröffentlicht in: | Journal of cellular physiology 2021-02, Vol.236 (2), p.1432-1444 |
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| creator | Liao, Shijie Feng, Wenyu Liu, Yun Wang, Ziyi Ding, Xiaofei Song, Fangming Lin, Xixi Song, Huijie KC, Anil Su, Yuangang Liang, Jiamin Xu, Jiake Liu, Qian Zhao, Jinmin |
| description | Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The effect of biochanin A (BCA) has been examined in osteoporosis, but no study on the role of BCA in prosthetic loosening osteolysis has been conducted yet. In this study, we utilised enzyme‐linked immunosorbent assay, computed tomography imaging, and histological analysis. Results showed that BCA downregulated the secretion levels of tumor necrosis factor‐α, interleukin‐1α (IL‐1α), and IL‐1β to suppress inflammatory responses. The secretion levels of receptor‐activated nuclear factor‐κB ligand, CTX‐1, and osteoclast‐associated receptor as well as Ti‐induced osteolysis were also reduced. BCA effectively inhibited osteoclastogenesis and suppressed hydroxyapatite resorption by downregulating OC‐related genes in vitro. Analysis of mechanisms indicated that BCA inhibited the signalling pathways of mitogen‐activated protein kinase (P38, extracellular signal‐regulated kinase, and c‐JUN N‐terminal kinase) and nuclear factor‐κB (inhibitor κB‐α and P65), thereby downregulating the expression of nuclear factor of activated T cell 1 and c‐Fos. In conclusion, BCA may be an alternative choice for the prevention of prosthetic loosening caused by OCs.
This is a valuable study on osteoclasts, which verified the effectiveness of traditional Chinese medicine monomer. |
| doi_str_mv | 10.1002/jcp.29948 |
| format | Article |
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This is a valuable study on osteoclasts, which verified the effectiveness of traditional Chinese medicine monomer.</description><identifier>ISSN: 0021-9541</identifier><identifier>EISSN: 1097-4652</identifier><identifier>DOI: 10.1002/jcp.29948</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc</publisher><subject>Artificial joints ; Biochanin A ; Biomedical materials ; Bone resorption ; Bone surgery ; Collagen ; Computed tomography ; Hydroxyapatite ; Inflammation ; inflammatory ; Interleukins ; JNK protein ; Kinases ; Loosening ; Lymphocytes ; MAP kinase ; MAPK ; NF‐κB ; osteoclast ; Osteoclastogenesis ; Osteoclasts ; Osteolysis ; Osteoporosis ; Prostheses ; Protein kinase ; Receptors ; Signal transduction ; Surgical implants ; Titanium</subject><ispartof>Journal of cellular physiology, 2021-02, Vol.236 (2), p.1432-1444</ispartof><rights>2020 Wiley Periodicals LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3308-7f8c618713bc8805a4eb4b16b00b016005981476b114b834174a1cc1e73020453</citedby><cites>FETCH-LOGICAL-c3308-7f8c618713bc8805a4eb4b16b00b016005981476b114b834174a1cc1e73020453</cites><orcidid>0000-0002-3094-0883 ; 0000-0003-0937-9670 ; 0000-0003-4087-3183 ; 0000-0002-8360-3899</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcp.29948$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcp.29948$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Liao, Shijie</creatorcontrib><creatorcontrib>Feng, Wenyu</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><creatorcontrib>Wang, Ziyi</creatorcontrib><creatorcontrib>Ding, Xiaofei</creatorcontrib><creatorcontrib>Song, Fangming</creatorcontrib><creatorcontrib>Lin, Xixi</creatorcontrib><creatorcontrib>Song, Huijie</creatorcontrib><creatorcontrib>KC, Anil</creatorcontrib><creatorcontrib>Su, Yuangang</creatorcontrib><creatorcontrib>Liang, Jiamin</creatorcontrib><creatorcontrib>Xu, Jiake</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Zhao, Jinmin</creatorcontrib><title>Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways</title><title>Journal of cellular physiology</title><description>Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The effect of biochanin A (BCA) has been examined in osteoporosis, but no study on the role of BCA in prosthetic loosening osteolysis has been conducted yet. In this study, we utilised enzyme‐linked immunosorbent assay, computed tomography imaging, and histological analysis. Results showed that BCA downregulated the secretion levels of tumor necrosis factor‐α, interleukin‐1α (IL‐1α), and IL‐1β to suppress inflammatory responses. The secretion levels of receptor‐activated nuclear factor‐κB ligand, CTX‐1, and osteoclast‐associated receptor as well as Ti‐induced osteolysis were also reduced. BCA effectively inhibited osteoclastogenesis and suppressed hydroxyapatite resorption by downregulating OC‐related genes in vitro. Analysis of mechanisms indicated that BCA inhibited the signalling pathways of mitogen‐activated protein kinase (P38, extracellular signal‐regulated kinase, and c‐JUN N‐terminal kinase) and nuclear factor‐κB (inhibitor κB‐α and P65), thereby downregulating the expression of nuclear factor of activated T cell 1 and c‐Fos. In conclusion, BCA may be an alternative choice for the prevention of prosthetic loosening caused by OCs.
This is a valuable study on osteoclasts, which verified the effectiveness of traditional Chinese medicine monomer.</description><subject>Artificial joints</subject><subject>Biochanin A</subject><subject>Biomedical materials</subject><subject>Bone resorption</subject><subject>Bone surgery</subject><subject>Collagen</subject><subject>Computed tomography</subject><subject>Hydroxyapatite</subject><subject>Inflammation</subject><subject>inflammatory</subject><subject>Interleukins</subject><subject>JNK protein</subject><subject>Kinases</subject><subject>Loosening</subject><subject>Lymphocytes</subject><subject>MAP kinase</subject><subject>MAPK</subject><subject>NF‐κB</subject><subject>osteoclast</subject><subject>Osteoclastogenesis</subject><subject>Osteoclasts</subject><subject>Osteolysis</subject><subject>Osteoporosis</subject><subject>Prostheses</subject><subject>Protein kinase</subject><subject>Receptors</subject><subject>Signal transduction</subject><subject>Surgical implants</subject><subject>Titanium</subject><issn>0021-9541</issn><issn>1097-4652</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp10UFu1DAUBmALgdShdNEbWGJDF2nfi53EWQ6jthQK7QLWke1xNB4ldrCdVrPjCKw4DIfgEJwEM8OqEivryd_79aSfkFOEcwQoL7Z6Oi_blotnZIHQNgWvq_I5WeQ_LNqK4xF5GeMWANqWsQX5ceM2Vtnkw46avjc6Rep7qqzXG-mso0vqHU025WEe6SRDsnowv799t249a7OmPibj9SBjolIn-yCTzRvSral1_SDHUe7DlXeGBhN9mPbgwUr66Srn_Pr5dq8_Lu8_5Py0eZS7-Iq86OUQzcm_95h8ubr8vHpX3N5d36yWt4VmDETR9ELXKBpkSgsBleRGcYW1AlCANUDVCuRNrRC5EoxjwyVqjaZhUAKv2DF5c8idgv86m5i60UZthkE64-fYlZyJuqmRYaavn9Ctn4PL12VVlzmsZJDV2UHp4GMMpu-mYEcZdh1C97ehLjfU7RvK9uJgH-1gdv-H3fvV_WHjD6fblUU</recordid><startdate>202102</startdate><enddate>202102</enddate><creator>Liao, Shijie</creator><creator>Feng, Wenyu</creator><creator>Liu, Yun</creator><creator>Wang, Ziyi</creator><creator>Ding, Xiaofei</creator><creator>Song, Fangming</creator><creator>Lin, Xixi</creator><creator>Song, Huijie</creator><creator>KC, Anil</creator><creator>Su, Yuangang</creator><creator>Liang, Jiamin</creator><creator>Xu, Jiake</creator><creator>Liu, Qian</creator><creator>Zhao, Jinmin</creator><general>Wiley Subscription Services, Inc</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3094-0883</orcidid><orcidid>https://orcid.org/0000-0003-0937-9670</orcidid><orcidid>https://orcid.org/0000-0003-4087-3183</orcidid><orcidid>https://orcid.org/0000-0002-8360-3899</orcidid></search><sort><creationdate>202102</creationdate><title>Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways</title><author>Liao, Shijie ; Feng, Wenyu ; Liu, Yun ; Wang, Ziyi ; Ding, Xiaofei ; Song, Fangming ; Lin, Xixi ; Song, Huijie ; KC, Anil ; Su, Yuangang ; Liang, Jiamin ; Xu, Jiake ; Liu, Qian ; Zhao, Jinmin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3308-7f8c618713bc8805a4eb4b16b00b016005981476b114b834174a1cc1e73020453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Artificial joints</topic><topic>Biochanin A</topic><topic>Biomedical materials</topic><topic>Bone resorption</topic><topic>Bone surgery</topic><topic>Collagen</topic><topic>Computed tomography</topic><topic>Hydroxyapatite</topic><topic>Inflammation</topic><topic>inflammatory</topic><topic>Interleukins</topic><topic>JNK protein</topic><topic>Kinases</topic><topic>Loosening</topic><topic>Lymphocytes</topic><topic>MAP kinase</topic><topic>MAPK</topic><topic>NF‐κB</topic><topic>osteoclast</topic><topic>Osteoclastogenesis</topic><topic>Osteoclasts</topic><topic>Osteolysis</topic><topic>Osteoporosis</topic><topic>Prostheses</topic><topic>Protein kinase</topic><topic>Receptors</topic><topic>Signal transduction</topic><topic>Surgical implants</topic><topic>Titanium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liao, Shijie</creatorcontrib><creatorcontrib>Feng, Wenyu</creatorcontrib><creatorcontrib>Liu, Yun</creatorcontrib><creatorcontrib>Wang, Ziyi</creatorcontrib><creatorcontrib>Ding, Xiaofei</creatorcontrib><creatorcontrib>Song, Fangming</creatorcontrib><creatorcontrib>Lin, Xixi</creatorcontrib><creatorcontrib>Song, Huijie</creatorcontrib><creatorcontrib>KC, Anil</creatorcontrib><creatorcontrib>Su, Yuangang</creatorcontrib><creatorcontrib>Liang, Jiamin</creatorcontrib><creatorcontrib>Xu, Jiake</creatorcontrib><creatorcontrib>Liu, Qian</creatorcontrib><creatorcontrib>Zhao, Jinmin</creatorcontrib><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cellular physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liao, Shijie</au><au>Feng, Wenyu</au><au>Liu, Yun</au><au>Wang, Ziyi</au><au>Ding, Xiaofei</au><au>Song, Fangming</au><au>Lin, Xixi</au><au>Song, Huijie</au><au>KC, Anil</au><au>Su, Yuangang</au><au>Liang, Jiamin</au><au>Xu, Jiake</au><au>Liu, Qian</au><au>Zhao, Jinmin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways</atitle><jtitle>Journal of cellular physiology</jtitle><date>2021-02</date><risdate>2021</risdate><volume>236</volume><issue>2</issue><spage>1432</spage><epage>1444</epage><pages>1432-1444</pages><issn>0021-9541</issn><eissn>1097-4652</eissn><abstract>Revision operations have become a new issue after successful artificial joint replacements, and periprosthetic osteolysis leading to prosthetic loosening is the main cause of why the overactivation of osteoclasts (OCs) plays an important role. The effect of biochanin A (BCA) has been examined in osteoporosis, but no study on the role of BCA in prosthetic loosening osteolysis has been conducted yet. In this study, we utilised enzyme‐linked immunosorbent assay, computed tomography imaging, and histological analysis. Results showed that BCA downregulated the secretion levels of tumor necrosis factor‐α, interleukin‐1α (IL‐1α), and IL‐1β to suppress inflammatory responses. The secretion levels of receptor‐activated nuclear factor‐κB ligand, CTX‐1, and osteoclast‐associated receptor as well as Ti‐induced osteolysis were also reduced. BCA effectively inhibited osteoclastogenesis and suppressed hydroxyapatite resorption by downregulating OC‐related genes in vitro. Analysis of mechanisms indicated that BCA inhibited the signalling pathways of mitogen‐activated protein kinase (P38, extracellular signal‐regulated kinase, and c‐JUN N‐terminal kinase) and nuclear factor‐κB (inhibitor κB‐α and P65), thereby downregulating the expression of nuclear factor of activated T cell 1 and c‐Fos. In conclusion, BCA may be an alternative choice for the prevention of prosthetic loosening caused by OCs.
This is a valuable study on osteoclasts, which verified the effectiveness of traditional Chinese medicine monomer.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/jcp.29948</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-3094-0883</orcidid><orcidid>https://orcid.org/0000-0003-0937-9670</orcidid><orcidid>https://orcid.org/0000-0003-4087-3183</orcidid><orcidid>https://orcid.org/0000-0002-8360-3899</orcidid></addata></record> |
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| subjects | Artificial joints Biochanin A Biomedical materials Bone resorption Bone surgery Collagen Computed tomography Hydroxyapatite Inflammation inflammatory Interleukins JNK protein Kinases Loosening Lymphocytes MAP kinase MAPK NF‐κB osteoclast Osteoclastogenesis Osteoclasts Osteolysis Osteoporosis Prostheses Protein kinase Receptors Signal transduction Surgical implants Titanium |
| title | Inhibitory effects of biochanin A on titanium particle‐induced osteoclast activation and inflammatory bone resorption via NF‐κB and MAPK pathways |
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